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Opportunities and challenges in the development of evolving EGFR inhibitors to overcome EGFR TKIs resistance

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Abnormal EGFR signaling is considered the cause of the occurrence and development of EGFR-addicted NSCLC. EGFR tyrosine kinase inhibitors (TKIs) have dramatically revolutionized the treatment landscape of NSCLC patients over the past two decades. Most patients... ...