The serotonin-gated 5-HT3 receptor: a tale of functions and structures of a prototypical pentameric ligand-gated ion channel [0.03%]
五聚体配体门控离子通道的典型代表——5-ht3受体的功能与结构研究：从血清素调控的离子通道到广泛的信号转导机制
Zhong-Jie Ye,Chen-Yang Wu,Hang Zhang et al.
Zhong-Jie Ye et al.
Serotonin-gated 5-HT3 receptors (5-HT3Rs), which belong to the cys-loop superfamily of ligand-gated ion channels, mediate fast excitatory neurotransmission in the central and peripheral nervous system. They are targets for drugs to treat ne...
Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway [0.03%]
Sonic Hedgehog-Gli1信号通过IKKβ/NF-κB途径促进小胶质细胞活化
Zhi-Rou Xu,Kan Wu,Rui-Ying Guo et al.
Zhi-Rou Xu et al.
The Sonic Hedgehog (Shh)-Gli1 signaling axis is essential for neuronal development, cell proliferation and homeostasis. However, its roles in microglial activation and neuroinflammation remain poorly defined. Here, we report that Shh is exp...
FPR2/ALX stimulation modulates microglia and natural killer cells to restrict autoimmune astrocytopathy [0.03%]
FPR2/ALX刺激调节小胶质细胞和自然杀伤细胞限制自身免疫性星形胶质细胞病变
Cai-Yun Qi,Li-Xiang Chen,Yi-Wei Fu et al.
Cai-Yun Qi et al.
Autoantibody- and complement-mediated cytotoxicity can cause autoimmune astrocytopathy that leads to CNS inflammatory demyelination. Formyl peptide receptor 2 (FPR2/ALX) governs the activation and propagation of immune response. However, th...
Correction: Berberine attenuates ischemia reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation [0.03%]
订正：番红花黄素通过抑制HMGB1释放和NF-κB核转位来减轻缺血再灌注损伤
Jun-Rong Zhu,Hai-Dan Lu,Chao Guo et al.
Jun-Rong Zhu et al.
Published Erratum
Acta pharmacologica Sinica. 2026 Mar 9. DOI:10.1038/s41401-026-01781-1 2026
Design and evaluation of peroxiredoxin 1 agonist based on scaffold hopping of salvianolic acids and combinatorial click chemistry [0.03%]
基于丹参素支架跳跃和组合点击化学的过氧化氢酶1激动剂的设计与评价
Yu-Yuan Zhu,Shuang Chen,Shu-Ning Zhang et al.
Yu-Yuan Zhu et al.
Peroxiredoxin 1 (PRDX1) is a pivotal antioxidant enzyme maintaining intracellular reactive oxygen species (ROS) balance. Deficiency of PRDX1 aggravates oxidative stress-related pathologies, whereas enhanced PRDX1 activity confers cytoprotec...
Correction: Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy [0.03%]
订正：阿司匹林通过抑制自噬缓解小鼠心脏纤维化
Ping-Ping Liu,Hong-Hong Liu,Shu-Hong Sun et al.
Ping-Ping Liu et al.
Published Erratum
Acta pharmacologica Sinica. 2026 Mar 4. DOI:10.1038/s41401-026-01780-2 2026
Targeted tumor starvation strategy augments radiosensitivity and enhances radioactive iodine-mediated tumor immunotherapy [0.03%]
靶向肿瘤饥饿策略增强放射敏感性并提高放射性碘介导的肿瘤免疫治疗效果
Ying Zhang,Zhi-Peng Liu,Zi-Yang Zhang et al.
Ying Zhang et al.
Radiopharmaceutical therapy (RPT) represents a critical approach in oncology, nevertheless its efficacy may be limited by tumor resistance mechanisms associated with metabolic reprogramming. Enhancing tumor radiosensitivity remains a major ...
Technology-enabled insights into SLC transporters in MAFLD: redefining the multi-hit pathogenesis and therapeutic landscape [0.03%]
技术赋能的SLC转运蛋白在MAFLD中的研究：重新定义多因素发病机制和治疗格局
Joseph Tawai,Jing Xiong
Joseph Tawai
Recent advances in structural biology, functional genomics, and artificial intelligence (AI) have expanded understanding of the solute carrier (SLC) transporter superfamily. Emerging evidence indicates that SLC transporters play central rol...
Pharmacological targeting of oncogenic condensates in cancer: mechanistic insights and therapeutic opportunities [0.03%]
抗癌药物靶向致癌凝聚体：机制见解和治疗机会
Qin-Kai Zhang,Ji-Zhao Cao,Wei Zhao
Qin-Kai Zhang
Biomolecular condensates formed through liquid-liquid phase separation (LLPS) have emerged as central organizers of cellular biochemistry. In cancer, dysregulated phase separation gives rise to oncogenic condensates that reprogram transcrip...
Cannabidiol inhibits both human KV7.1 and KV7.1/KCNE1 channels through distinct sites [0.03%]
大麻二酚通过不同作用位点抑制人类KV7.1和KV7.1/KCNE1通道
A S Kusay,M Pökl,I Hiniesto-Iñigo et al.
A S Kusay et al.
Several essential physiological systems express voltage-gated potassium channels within the KV7 family (comprising KV7.1-7.5), sometimes also co-assembled with auxiliary subunits in the KCNE family (comprising KCNE1-5). An ongoing challenge...