Recent advances in the development of GRK2 inhibitors: blocking the interaction of GRK2 with its partners
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G protein-coupled receptor kinase 2 (GRK2) is a key player in signal transduction and contains an N-terminus, a kinase domain (KD) and a C-terminus. Changes in the configuration of GRK2 regulate its allosteric effects, including KD closure and protein binding,... ...
