Reductive Stress in Myocardial Ischemia: Mechanisms, Pathophysiology, and Therapeutic Perspectives [0.03%]
心肌缺血中的还原应激：机制、病理生理及治疗观点
Gino A Kurian
Gino A Kurian
Reductive stress (RS), characterized by excessive accumulation of reducing equivalents including NADH, NADPH, and glutathione, is increasingly recognized as a potential contributor to myocardial ischemic heart disease. Conventional models o...
The Context-Dependent Bidirectional Regulation of Lactylation in Hypoxia-Driven Pathologies: A Tripartite Framework [0.03%]
缺氧驱动疾病中的乳酰化双向调控的上下文依赖性：三元框架理论
Yuwen Dai,Ziqing Wang,Leyan Chen et al.
Yuwen Dai et al.
Lysine lactylation (Kla) has emerged as a definitive mechanistic bridge coupling cellular metabolic flux to epigenetic and proteomic reprogramming. Driven by hypoxia-induced lactate accumulation, this dynamic post-translational modification...
The Impact of a High Folic Acid and Low Vitamin B12 Diet on Oxidative Stress in Dams at Delivery and Young Offspring: Sex Matters [0.03%]
高叶酸和低维生素B12饮食对分娩母鼠及子代小鼠氧化应激的影响：性别有差异
Erika Castaño-Moreno,Valeska Castillo,Daphne Álvarez et al.
Erika Castaño-Moreno et al.
Maternal micronutrient imbalances during pregnancy can interfere with fetal development by affecting oxidative stress pathways. Folic acid (FA) and vitamin B12, essential components of one-carbon metabolism, are especially crucial. This stu...
Combined Senolytics Induce Varied Phenotypic and Functional Responses on Senescent Phenotypes of Mesenchymal Stromal Cell Populations [0.03%]
联合使用辛诺西林诱导骨髓间充质基质细胞群体衰老表型的多种变化及功能响应
David P Heinrichs,Thomas Needy,Vitali Maldonado et al.
David P Heinrichs et al.
Mesenchymal stem cells have emerged as a pivotal focus in regenerative medicine and therapeutic innovation due to their multipotent differentiation capacity and immunomodulatory properties. A major obstacle in maintaining human MSC potency ...
Globular oligomers as the building block units of the filamentous structure of E. coli small heat shock protein IbpA and their holding chaperone activity [0.03%]
肠杆菌科小热休克蛋白IbpA纤维状结构的球状低聚体构建单元及其保持型分子伴侣活性
Md Azaharuddin,Abhijit Das,Susmita Nandi et al.
Md Azaharuddin et al.
In E. coli, IbpA is a small heat-shock protein, which acts as molecular chaperone with only holdase activity. At normal temperature, IbpA monomers oligomerize to form filamentous structure of molecular weight in mega-Dalton range, whereas a...
Guggulsterone as a Modulator of the Microbiota-Bile Acid-FXR Axis: Molecular Mechanisms and Therapeutic Potential in Metabolic Ageing [0.03%]
他格芦丁通过调节肠道菌群-胆汁酸-FXR轴抑制代谢衰老的分子机制及潜在作用研究
Alexander Ravikumar,Sarvesh Sabarathinam
Alexander Ravikumar
Cholesterol biosynthesis and bile acid metabolism are tightly controlled by the Farnesoid X receptor (FXR), which integrates bile acid signaling with lipid, glucose, and inflammatory pathways to maintain metabolic homeostasis. Gut microbiot...
Neuwlectin, a novel C-type lectin from Bothrops neuwiedi venom, inhibits platelet aggregation induced by cancer cells and angiogenesis [0.03%]
新型C型凝集素Neuwlectin通过抑制癌细胞诱导的血小板聚集和血管生成发挥抗肿瘤作用
Amanda Del Rio Abreu Rosa,Valéria Gonçalves Alvarenga,Mariana Roberta Assrauy Pinheiro et al.
Amanda Del Rio Abreu Rosa et al.
C-type lectins are the major non-enzymatic protein constituents in Viperidae venoms. Neuwlectin, a novel member of the C-type lectin family, was purified to homogeneity from Bothrops neuwiedi venom and characterized as a 32.2 kDa homodimer ...
Functional assignments of the ubiquitination sites K62 and K230 of the human ribosomal protein uS3 (RPS3) [0.03%]
人类核糖体蛋白uS3(RPS3)泛素化位点K62和K230的功能研究
Konstantin Bulygin,Anastasia Ochkasova,Andrey Krasnikov et al.
Konstantin Bulygin et al.
Ribosomal protein uS3/RPS3 in eukaryotes is an essential component of the 40S ribosomal subunit, where it interacts with mRNA and initiation factors. It also has various extra-ribosomal functions. Proteomic studies have identified several u...
Involvement of extracellular DNA (eDNA) in biofilm architecture and extracellular polymeric matrix stabilization in Pseudomonas putida KT2440 [0.03%]
荧光假单胞菌KT2440中胞外DNA（eDNA）在生物被膜结构及胞外多聚物基质稳定化中的作用
Sonalin Rath,Shourat Fatma,Ankit Kumar Nayak et al.
Sonalin Rath et al.
Bacterial biofilms are structured communities encased in extracellular polymeric substances (EPS), with extracellular DNA (eDNA) as a key structural and regulatory component. This study investigates the role of eDNA in biofilm architecture ...
Substituted Cysteine Accessibility Method (SCAM) in Membrane Transporters Studies:Learn from Lactose Permease [0.03%]
膜蛋白中靶半胱氨酸可及性方法（SCAM）研究 lactose permease 的启示
Xiaoxu Jiang,Vatchilasack Booncherm,Harjot Gill et al.
Xiaoxu Jiang et al.
Membrane transporters are membrane-embedded proteins that mediate the translocation of a great variety of ions and small molecules across biological membranes. Due to the highly hydrophobic environment in which they reside, transporters hav...