Metabolic response of Haloferax mediterranei to different amino acids as a nitrogen source: from rich to limiting nitrogen conditions [0.03%]
产盐红球菌对不同氮源的代谢响应：从丰富的氮条件到限制性氮条件
B Zafrilla,M Camacho,V Bautista et al.
B Zafrilla et al.
Haloferax mediterranei, a halophilic archaeon, exhibits remarkable adaptability to nitrogen availability by using a wide range of nitrogen sources, including inorganic compounds and single amino acids. To investigate the organism's transcri...
Glycosylation control strategies for recombinant therapeutic proteins in CHO cells [0.03%]
CHO细胞中重组药物蛋白糖基化的调控策略
Weifeng Wang,Weidong Li,Qianwen Wang et al.
Weifeng Wang et al.
Chinese hamster ovary (CHO) cells are widely employed as host cells for the production of recombinant therapeutic proteins (RTPs). Glycosylation, a crucial post-translational modification, significantly affects the function and quality of R...
Diverse ligands for mycobacterial CYP124 identified from plant and marine compounds [0.03%]
来自植物和海洋化合物的分枝杆菌CYP124的多种配体
Leonid Kaluzhskiy,Evgeniy Yablokov,Tatsiana Varaksa et al.
Leonid Kaluzhskiy et al.
Tuberculosis persists as a major global health threat, significantly exacerbated by the rise of drug-resistant strains. Cytochrome P450 of 124 family CYP124 from Mycobacterium tuberculosis (CYP124), implicated in host sterol metabolism and ...
Interplay between cholesterol, Bis(monoacylglycerol)phosphate, and parasitophorous vacuole dynamics in Leishmania infantum infection of macrophages [0.03%]
胆固醇、双单酰基甘油磷酸和利什曼原虫感染巨噬细胞的寄生虫包囊动力学之间的相互作用研究
Clara Hennot,Marine Leroux,Remi Lambert et al.
Clara Hennot et al.
Leishmania spp., the causative agents of leishmaniasis, are protozoan parasites displaying two life stages: promastigote in the insect vector and amastigote in host macrophages. After inoculation, the promastigote differentiates into the am...
The sting that clots: The Factor VII and Factor X activating procoagulant effects of Androctonus scorpion venoms are potentiated by Factor Va as a cofactor [0.03%]
致使凝血的蝎毒：Androctonus蝎子毒液通过V因子作用激活FVII和FX的促凝活性
Sam I D Campbell,Lorenzo Seneci,Lee Jones et al.
Sam I D Campbell et al.
While scorpion venoms are well-characterised as being potently neurotoxic, their effects upon blood coagulation are understudied. Here, we report novel procoagulant toxicological functions for Androctonus amoreuxi, A. australis, A. bicolor ...
Arturo Tozzi,Raffaele Minella
Arturo Tozzi
Optimal transport models may provide a robust framework for quantifying gas movement from the intestinal lumen into the gut layers in pneumatosis intestinalis (PI), a condition characterized by abnormal gas accumulation within the intestina...
Discovery of 6,7-Dimethoxyquinazoline-Hydrazide Hybrids as Dual Inhibitors of Acetylcholinesterase and β-Secretase [0.03%]
6,7-二甲氧基喹唑啉-肼衍生物作为乙酰胆碱酯酶和β-分泌酶双重抑制剂的研究发现
Giorgio Antoniolli,Mohamed T M Nemr,Samuel Pedro Dantas Marques et al.
Giorgio Antoniolli et al.
A novel series of 6,7-dimethoxyquinazoline-hydrazide hybrids 1-4 were designed, synthesized, and tested for their AChE inhibition activity using the qualitative assay, which showed that compounds 3 and 4 exhibited their activity via TLC. Th...
Aryl hydrocarbon receptor signaling in osteosarcopenia: an integrative framework for musculoskeletal aging [0.03%]
芳香烃受体在骨肌萎缩症中的信号传导：骨骼肌肉衰老的综合框架
Hassan Rammal,Alex M Noonan,Daniel Rivas et al.
Hassan Rammal et al.
Aging is accompanied by a progressive decline in tissue integrity and functional capacity and is a major risk factor for chronic disease. Osteosarcopenia, defined as the concurrent loss of bone and skeletal muscle mass and function, is a ma...
Potential cardioprotective and regenerative effects of the fluorinated benzothiazole derivative AS09 in the myocardial infarction-induced zebrafish [0.03%]
新型化合物AS09在心肌梗死斑马鱼模型中心脏保护及心脏再生作用的研究
Santhanam Sanjai Dharshan,Shreya Madhankumar Rao,S P Ramya Ranjan Nayak et al.
Santhanam Sanjai Dharshan et al.
Myocardial infarction (MI), a significant complication of coronary artery disease (CAD), results from prolonged myocardial ischemia. Generally, MI is caused by the rupture of an atherosclerotic plaque and thrombus formation. Among various p...
Multiple strategies for HB-EGF inhibition: interference with receptor binding, ectodomain shedding and matricrine signaling [0.03%]
HB-EGF抑制的多种策略：干扰受体结合、细胞外结构域脱落和基质信号转导
Andrii Siromolot,Dariia Zhukova,Svitlana Romaniuk et al.
Andrii Siromolot et al.
Nontoxic analogues of Corynebacterium diphtheriae exotoxin can inhibit the binding of heparin-binding EGF-like growth factor (HB-EGF) to tumor cell receptors, while targeting its heparin-binding site or preventing ectodomain shedding can fu...