Phosphatidylethanolamine as an exclusive substrate for an original phospholipase D from Dechloromonas [0.03%]
磷脂酰乙醇胺作为脱氯单胞菌来源的一种原始磷脂酶D的专属底物
Zongze Wu,Sébastien Violot,Abdelkarim Abousalham et al.
Zongze Wu et al.
Phospholipases D (PLDs) are lipolytic enzymes that catalyze hydrolysis of the distal phosphodiester bond of various membrane phospholipids (PLs). These enzymes generate invariant phosphatidic acid (PA) and a polar head group whose nature de...
New Perspectives on the Role of Aryl Hydrocarbon Receptor Signaling in the Aging Musculoskeletal System [0.03%]
芳香烃受体在衰老骨骼肌系统中的作用的新视角
Meghan E McGee-Lawrence,Mark W Hamrick,Carlos M Isales
Meghan E McGee-Lawrence
Acute Local and Systemic Effects of Intra-Articular Administration of Liposomal IDO-1 following Anterior Cruciate Ligament Rupture [0.03%]
内侧副韧带撕裂后局部和全身性给药脂质体IDO-1的急性效果
Mackenzie Fleischer,Michael Newton,Samantha Hartner et al.
Mackenzie Fleischer et al.
Joint injuries, such as rupture of the anterior cruciate ligament (ACL), are associated with the development of post-traumatic osteoarthritis (PTOA). ACL rupture can lead to disruption of metabolic pathways, including the conversion of tryp...
Mechanistic Determinants of Fatty Acid Chain Length in Fatty Acid Synthase: The case of dairy fat [0.03%]
奶牛脂肪中硬脂酸合成酶决定棕榈酸链长的机制因素——以乳脂肪为例
Bar Sutker,Roni Tadmor-Levi,Maggie Levy et al.
Bar Sutker et al.
Lipid chemical and structural properties are responsible for both the technological, health and rheological properties of dairy products. Inability to properly mimic those compositional properties will result in lower product quality as wel...
Screening and Inhibition Mechanism Study of Novel ACE-Inhibitory Peptides from Silkworm pupa [0.03%]
家蚕蛹中新型ACE抑制肽的筛选及抑制机理研究
Jinhua Zhang,Jing Liang,Baoqing Bai et al.
Jinhua Zhang et al.
Numerous natural angiotensin-converting enzyme (ACE) inhibitors (ACEIs) have been extensively studied and applied for the prevention and control of hypertension. This study conducted sequence analysis and computer screening on ACE inhibitor...
Chronic oxidative stress leads to the accumulation of reversibly oxidised thiamine derivatives in tissues: effects of thiamine and cholecalciferol [0.03%]
慢性氧化应激导致组织中可逆氧化硫胺素衍生物的积累：维生素B1和维生素D的影响
Yu M Parkhomenko,M M Veliky,O S Pavlova et al.
Yu M Parkhomenko et al.
There is limited data on oxidised thiamine (vitamin B1) derivatives in animal and human tissues. Some studies suggest that oxidative stress (OS) leads to their formation. This study aimed to estimate the proportion of reversibly oxidised (d...
Maternal dietary n-3 PUFA deficiency leads to sex-specific alterations in placental and cerebral fatty acid profiles and in oxylipin profiles in the developing mouse brain [0.03%]
母体饮食中n-3多不饱和脂肪酸缺乏导致小鼠胎盘和大脑性别的脂肪酸谱以及发育中大脑中的氧脂素谱的性别特异性改变
Flore Marchaland,Maud Martinat,Mathieu Di Miceli et al.
Flore Marchaland et al.
Long-chain polyunsaturated fatty acids (LC-PUFAs), particularly arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), are essential for optimal neurodevelopment through their effect on neuronal proliferation, neurite outgr...
Catalytic scavenging of ROS: A mechanistic review of CeO2 NPs and Fe3O4 NPs as prototypical antioxidant nanozymes [0.03%]
催化清除ROS：作为原型抗氧化纳米酶的CeO₂ NPs和Fe₃O₄ NPs的作用机制综述
Ammar A Tawfeeq,Th T Mohammed,Bilal J M Aldahham
Ammar A Tawfeeq
The rising global burden of diseases linked to reactive oxygen and nitrogen species (ROS/RNS) - including inflammatory disorders, cancers, neurodegenerative conditions, and cardiovascular disease - has intensified interest in enzyme-mimicki...
Modulation of N-cadherin-mediated homophilic trans interaction upon direct binding of ADH-1: Exploring the molecular basis of action of ADH-1 as N-cadherin inhibitor [0.03%]
ADH-1通过直接结合调控N-钙黏蛋白介导的同型细胞间相互作用：探索ADH-1作为N-钙黏蛋白抑制剂的作用机制分子基础
Jayita Biswas,Saumyadeep Goswami,Sagarika Dash et al.
Jayita Biswas et al.
Switching of cadherin expression patterns, as linked to epithelial-to-mesenchymal transition (EMT), is one of the most notable characteristics of cancer cell metastasis. Aberrant expression of N-cadherin, a cell adhesion protein, on tumour ...
ER quality control: how cells detoxify their own membrane from lipid stress [0.03%]
内质网质量控制：细胞如何从脂质压力中净化其自身膜
Helin Elhan,Abdou Rachid Thiam
Helin Elhan
The endoplasmic reticulum (ER) is the principal site of glycerolipid synthesis in eukaryotic cells. The continuous production of lipid intermediates, including phosphatidic acid (PA), diacylglycerol (DAG), and triacylglycerol (TAG), destabi...