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The Context-Dependent Bidirectional Regulation of Lactylation in Hypoxia-Driven Pathologies: A Tripartite Framework

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Lysine lactylation (Kla) has emerged as a definitive mechanistic bridge coupling cellular metabolic flux to epigenetic and proteomic reprogramming. Driven by hypoxia-induced lactate accumulation, this dynamic post-translational modification fundamentally dicta... ...