Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance [0.03%]
组蛋白去乙酰化促进异染色质域的自我传播以促进表观遗传学继承
Martin Zofall,Rima Sandhu,Sahana Holla et al.
Martin Zofall et al.
Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is nucleated at specific genomic sites but can self-propagate across extended domains and, indeed, generations. Self-propagation requires Clr4/Suv39h methyltransf...
The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination [0.03%]
DNA损伤激酶ATR通过泛素化起始激活FANCD2-FANCI滑动夹复合体
Tamara Sijacki,Pablo Alcón,Zhuo A Chen et al.
Tamara Sijacki et al.
DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FAN...
Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation [0.03%]
CRL7FBXW8 结构揭示了与 CUL1-RBX1/ROC1 耦合以催化多 cullin-RING E3 泛素连接酶的机制
Linus V M Hopf,Kheewoong Baek,Maren Klügel et al.
Linus V M Hopf et al.
Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and a variable substrate-binding receptor (for example, an F-box protein). However, the vertebrate-specific CRL7FBXW8 is ...
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119 [0.03%]
孤儿受体GPR119的活化配体溶血磷脂酰胆碱的结构鉴定
Peiyu Xu,Sijie Huang,Shimeng Guo et al.
Peiyu Xu et al.
Lysophosphatidylcholine (LPC) is an essential mediator in human lipid metabolism and is associated with a variety of diseases, but the exact identity of LPC receptors remains controversial. Through extensive biochemical and structural analy...
Sara Osman
Sara Osman
Carolina N Perdigoto
Carolina N Perdigoto
Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST [0.03%]
填补空白：端粒酶通过CST追赶G链以完成染色体末端DNA复制
Conner L Olson,Alexandra T Barbour,Deborah S Wuttke
Conner L Olson
Jesús R Requena
Jesús R Requena
Karl Frontzek,Marco Bardelli,Assunta Senatore et al.
Karl Frontzek et al.
Prion infections cause conformational changes of the cellular prion protein (PrPC) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond ('H-latch'),...