Building a molecular rotor [0.03%]
构建分子转子
Florian Ullrich
Florian Ullrich
Carolina N Perdigoto
Carolina N Perdigoto
Beth Moorefield
Beth Moorefield
Elena A Zehr,Antonina Roll-Mecak
Elena A Zehr
Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state [0.03%]
人类CST-Polα/原核复合物募集状态下的低温EM结构
Sarah W Cai,John C Zinder,Vladimir Svetlov et al.
Sarah W Cai et al.
The CST-Polα/primase complex is essential for telomere maintenance and functions to counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure of human CST-Polα/primase, captured prior to catalysis in a ...
Ciliary central apparatus structure reveals mechanisms of microtubule patterning [0.03%]
纤毛中央发生装置结构揭示了微管图案形成的机制
Miao Gui,Xiangli Wang,Susan K Dutcher et al.
Miao Gui et al.
A pair of extensively modified microtubules form the central apparatus (CA) of the axoneme of most motile cilia, where they regulate ciliary motility. The external surfaces of both CA microtubules are patterned asymmetrically with large pro...
Long Han,Qinhui Rao,Renbin Yang et al.
Long Han et al.
Accurately regulated ciliary beating in time and space is critical for diverse cellular activities, which impact the survival and development of nearly all eukaryotic species. An essential beating regulator is the conserved central apparatu...
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair [0.03%]
HMCESDNA-蛋白交联在DNA间链交联修复中作为中间体发挥作用
Daniel R Semlow,Victoria A MacKrell,Johannes C Walter
Daniel R Semlow
The 5-hydroxymethylcytosine binding, embryonic stem-cell-specific (HMCES) protein forms a covalent DNA-protein cross-link (DPC) with abasic (AP) sites in single-stranded DNA, and the resulting HMCES-DPC is thought to suppress double-strand ...
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins [0.03%]
线性链和低势能氢键在蛋白质结构与功能中的作用的真原子分辨率见解
Valentin Borshchevskiy,Kirill Kovalev,Ekaterina Round et al.
Valentin Borshchevskiy et al.
Hydrogen bonds are fundamental to the structure and function of biological macromolecules and have been explored in detail. The chains of hydrogen bonds (CHBs) and low-barrier hydrogen bonds (LBHBs) were proposed to play essential roles in ...