Andrea Cerase,J Mauro Calabrese,Gian Gaetano Tartaglia
Andrea Cerase
Sara Osman
Sara Osman
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome [0.03%]
Xist通过空间放大SHARP/SPEN募集来平衡整个染色体的沉默并与X染色体特异性相结合
Joanna W Jachowicz,Mackenzie Strehle,Abhik K Banerjee et al.
Joanna W Jachowicz et al.
Although thousands of long non-coding RNAs (lncRNAs) are encoded in mammalian genomes, their mechanisms of action are poorly understood, in part because they are often expressed at lower levels than their proposed targets. One such lncRNA i...
Beth Moorefield
Beth Moorefield
Florian Ullrich
Florian Ullrich
Acetylation-dependent SAGA complex dimerization promotes nucleosome acetylation and gene transcription [0.03%]
乙酰化依赖的SAGA复合物二聚化促进核小体乙酰化和基因转录
Junhua Huang,Wenjing Dai,Duncheng Xiao et al.
Junhua Huang et al.
Cells reprogram their transcriptomes to adapt to external conditions. The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex is a highly conserved transcriptional coactivator that plays essential roles in cell growth and development, in part by ...
Structural mechanism of muscle nicotinic receptor desensitization and block by curare [0.03%]
箭毒通过结构机制阻断烟碱型乙酰胆碱受体引发肌肉脱敏作用
Md Mahfuzur Rahman,Tamara Basta,Jinfeng Teng et al.
Md Mahfuzur Rahman et al.
Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes the membrane and thereby triggers muscle contraction. We sought to understand at the level of three-dimensional structure how agonists and antagonis...
Re-wiring for starvation [0.03%]
重新连线以应对饥荒
Carolina N Perdigoto
Carolina N Perdigoto
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH [0.03%]
人糖蛋白GP-2及尿酸酶的诱饵模块结构及其与细菌粘附素FimH的相互作用
Alena Stsiapanava,Chenrui Xu,Shunsuke Nishio et al.
Alena Stsiapanava et al.
Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cr...
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex [0.03%]
联体会议 EM 揭示 SARS-CoV-2 解旋酶复制-转录复合物中 nsp13 解旋酶的构象状态
James Chen,Qi Wang,Brandon Malone et al.
James Chen et al.
The SARS-CoV-2 nonstructural proteins coordinate genome replication and gene expression. Structural analyses revealed the basis for coupling of the essential nsp13 helicase with the RNA-dependent RNA polymerase (RdRp) where the holo-RdRp an...