The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination
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DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2-FANCI clamp by t... ...
