Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance
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Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is nucleated at specific genomic sites but can self-propagate across extended domains and, indeed, generations. Self-propagation requires Clr4/Suv39h methyltransferase recruitment by... ...
