Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics [0.03%]
人源THIK-1 K2P K+通道的低温电镜结构揭示了由脂质和麻醉剂调控的一个低Y门控
Karin E J Rödström,Bisher Eymsh,Peter Proks et al.
Karin E J Rödström et al.
THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K+ channel implicated in microglial activation and neuroinflammation, and a current target for the treatment of neurodegenerative disorders, for exam...
Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin [0.03%]
DEK如何通过结合核小体来促进染色质中H3K27三甲基化的结构洞察
Tomoya Kujirai,Kenta Echigoya,Yusuke Kishi et al.
Tomoya Kujirai et al.
Structural diversity of the nucleosome affects chromatin conformations and regulates eukaryotic genome functions. Here we identify DEK, whose function is unknown, as a nucleosome-binding protein. In embryonic neural progenitor cells, DEK co...
CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association [0.03%]
CTCF/RAD21组织染色质-核斑点关联的基态
Ruofan Yu,Shelby Roseman,Allison P Siegenfeld et al.
Ruofan Yu et al.
Recent findings indicate that nuclear speckles, a distinct type of nuclear body, interact with certain chromatin regions in a ground state. Here, we report that the chromatin structural factors CTCF and cohesin are required for full ground-...
Chad W Hicks,Colin R Gliech,Sanim Rahman et al.
Chad W Hicks et al.
Phosphorylation of histone H3 threonine 3 (H3T3) by Haspin recruits the chromosomal passenger complex to the inner centromere and ensures proper cell cycle progression through mitosis. The mechanism by which Haspin binds to nucleosomes to p...
Julia A Rocereta,Toni Sturhahn,Ruth A Pumroy et al.
Julia A Rocereta et al.
The transient receptor potential vanilloid 2 (TRPV2) cation channel is a key player in cardiovascular physiology and pathophysiology. Probenecid (PBC), an FDA-approved uricosuric agent thought to activate TRPV2, has shown promise in enhanci...
Meng Zhang,Yaxu Wang,M Madan Babu
Meng Zhang
Dimitris Typas
Dimitris Typas
Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition [0.03%]
转录终止酶RNA聚合酶II调控人类细胞类型转换过程中的转录
Kseniia Lysakovskaia,Arjun Devadas,Björn Schwalb et al.
Kseniia Lysakovskaia et al.
Metazoan gene transcription by RNA polymerase II (Pol II) is regulated in the promoter-proximal region. Pol II can undergo termination in the promoter-proximal region but whether this can contribute to transcription regulation in cells rema...