Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis [0.03%]
CTBP和TRIM28的互惠稳定抑制自噬促进转移
Lixin Tai,Dongliang Zhu,Ping Tang et al.
Lixin Tai et al.
Deciphering the processes through which cancer cells overcome stress, escape a repressive microenvironment and metastasize remains a challenge. Autophagy has been demonstrated to regulate cancer metastasis and C-terminal binding protein (Ct...
Pietro De Camilli,Karin M Reinisch
Pietro De Camilli
Katarzyna Marcinkiewicz
Katarzyna Marcinkiewicz
Katarzyna A Ciazynska
Katarzyna A Ciazynska
CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation [0.03%]
CTCF缺失解耦增强子介导的基因激活和染色质聚集体形成
Magdalena A Karpinska,Yi Zhu,Zahra Fakhraei Ghazvini et al.
Magdalena A Karpinska et al.
Enhancers and promoters interact in three-dimensional (3D) chromatin structures to regulate gene expression. Here we characterize the mechanisms that drive the formation and function of these structures in a lymphoid-to-myeloid transdiffere...
Darío G Lupiáñez
Darío G Lupiáñez
Flexing protein assemblies [0.03%]
可变形的蛋白质组装体
Yang Li,Yang Zhang
Yang Li
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 [0.03%]
嵌合型去泛素酶工程揭示线粒体自噬调节因子USP30特异性抑制的结构基础
Nafizul Haque Kazi,Nikolas Klink,Kai Gallant et al.
Nafizul Haque Kazi et al.
The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1-parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is current...
Slow awakening of the silent X chromosome in female primordial germ cells [0.03%]
原始生殖细胞中静默的X染色体缓慢激活
Christine M Disteche,Xinxian Deng
Christine M Disteche
piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation [0.03%]
piRNA基因密度和SUMO化组织piRNA转录凝聚体形成
Chengming Zhu,Xiaoyue Si,Xinhao Hou et al.
Chengming Zhu et al.
Piwi-interacting RNAs (piRNAs) are essential for maintaining genome integrity and fertility in various organisms. In flies and nematodes, piRNA genes are encoded in heterochromatinized genomic clusters. The molecular mechanisms of piRNA tra...