Rilee Zeinert,Fei Zhou,Pedro Franco et al.
Rilee Zeinert et al.
Magnesium (Mg2+) uptake systems are present in all domains of life, consistent with the vital role of this ion. P-type ATPase Mg2+ importers are required for bacterial growth when Mg2+ is limiting or during pathogenesis. However, insights i...
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism [0.03%]
ACAD10和ACAD11使哺乳动物能够代谢4-羟基酸类脂质
Edrees H Rashan,Abigail K Bartlett,Daven B Khana et al.
Edrees H Rashan et al.
Fatty acid β-oxidation is a central catabolic pathway with broad health implications. However, various fatty acids, including 4-hydroxy acids (4-HAs), are largely incompatible with β-oxidation machinery before being modified. Here we reve...
Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks [0.03%]
组蛋白标记的组合决定了异染色质蛋白Rhino与部分piRNA基因簇的结合
Abdou Akkouche,Emma Kneuss,Susanne Bornelöv et al.
Abdou Akkouche et al.
Animal germ cells deploy a specialized small RNA-based silencing system, called the PIWI-interacting RNA (piRNA) pathway, to prevent unwanted expression of transposable elements (TEs) and maintain genome integrity. In Drosophila melanogaste...
Arantxa M L Rojas,Germano Cecere
Arantxa M L Rojas
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation [0.03%]
TRPML1激活后DMXL1促进V1-ATP酶募集到溶酶体中
Chan Lee,Matthew J G Eldridge,Miguel A Gonzalez-Lozano et al.
Chan Lee et al.
Lysosomes, central hydrolytic organelles, are regulated by ion flow, including calcium and protons, via transporters and channels to maintain an acidified lumen for hydrolytic activity. TRPML1, a lysosomal ion channel, effluxes cations upon...
Better SIFI than sorry [0.03%]
与其抱憾不如防患于未然
Sara Osman
Sara Osman
Dimitris Typas
Dimitris Typas
H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes [0.03%]
H2A.Z增强母源H3K4me3形成并在小鼠卵母细胞减数分裂进程中必不可少
Hailiang Mei,Ryoya Hayashi,Chisayo Kozuka et al.
Hailiang Mei et al.
Mammalian oocytes establish a unique landscape of histone modifications, some of which are inherited by early embryos. How histone variants shape the maternal histone landscape remains unknown. Here we map histone H2A variants in mouse full...