Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4 [0.03%]
核心拼接结构和早期拼接识别决定了微小外显子对SRRM3/4的敏感性
Sophie Bonnal,Simon Bajew,Rosa Martinez-Corral et al.
Sophie Bonnal et al.
Microexons are essential for the proper operation of neurons and pancreatic endocrine cells, in which their inclusion depends on the splicing factors SRRM3 and SRRM4 (SRRM3/4). However, in pancreatic cells, lower expression of these regulat...
Establishment of the phagophore-ERES membrane contact site initiates phagophore elongation [0.03%]
吞噬体-内质网接触位点的建立启动吞噬体延伸
Rubén Gómez-Sánchez,Sabrina Chumpen Ramirez,Prado Vargas Duarte et al.
Rubén Gómez-Sánchez et al.
The de novo generation of membrane contact sites (MCSs) between the phagophore and the endoplasmic reticulum exit sites (ERES) is important for the acquisition of the lipids necessary for phagophore elongation and autophagosome formation du...
Anne Schreiber
Anne Schreiber
Hana Polasek-Sedlackova
Hana Polasek-Sedlackova
Shengchun Zhang,Ran Yi,Linfeng An et al.
Shengchun Zhang et al.
RNA-only complexes adopt intricate three-dimensional structures to fulfill diverse functions independently of protein partners. Although multimeric RNA-only structures have been engineered in synthetic RNA nanomaterials, naturally occurring...
Jingjing Gao,Christopher Nardone,Matthew C J Yip et al.
Jingjing Gao et al.
Proteasomes degrade diverse proteins in different cellular contexts through incompletely defined regulatory mechanisms. Here we report the cryo-EM structure of human thioredoxin-like protein 1 (TXNL1) bound to the 19S regulatory particle of...
GAGA zinc finger transcription factor searches chromatin by 1D-3D facilitated diffusion [0.03%]
GAGA锌指转录因子通过一维-三维促扩散在染色质中搜索
Xinyu A Feng,Maryam Yamadi,Yiben Fu et al.
Xinyu A Feng et al.
The search for target sites on chromatin by eukaryotic sequence-specific transcription factors (TFs) is integral to the regulation of gene expression but the mechanism of nuclear exploration has remained obscure. Here we use multicolor sing...
Baihui Wang,Rafael Kronenberg-Tenga,Valentina Rosti et al.
Baihui Wang et al.
In the cell nucleus, chromatin is anchored to the nuclear lamina, a network of lamin filaments and binding proteins that underly the inner nuclear membrane. The nuclear lamina is involved in chromatin organization through the interaction of...
Stephanie Webb,Katerina Toropova,Aakash G Mukhopadhyay et al.
Stephanie Webb et al.
Members of the kinesin-2 family coordinate with other motors to power diverse physiological processes, but the structural mechanisms regulating kinesin-2 activity have been unknown. Distinctively, kinesin-2s canonically function as heterotr...
Lidia Wrobel
Lidia Wrobel