Role of Dissolution Medium pH in the Release Behavior of Basic Drug-Copovidone Amorphous Solid Dispersions [0.03%]
溶解介质pH值对碱性药物共蒸发无定型固体分散体释放行为的影响研究
Taiga Uekusa,Siddhi S Hate,Kirk A VanDer Kamp et al.
Taiga Uekusa et al.
Amorphous solid dispersions (ASDs) are one of the most effective formulation strategies for improving the release rate and bioavailability of poorly water-soluble drugs. However, the release rates of polyvinylpyrrolidone vinyl acetate (PVPV...
Synthesis and In Vivo and In Vitro Properties of 99mTc-Labeled Fibroblast Activation Protein Inhibitors [0.03%]
新型纤维激活蛋白抑制剂的制备及其体内外性质研究
Sufan Tang,Zhicong Yang,Jiaqi Nie et al.
Sufan Tang et al.
Fibroblast activation protein (FAP) is expressed in more than 90% of tumor-associated fibroblasts in epithelial cancers, providing an excellent target for nuclear medicine diagnostics and therapy. Given the high cost of PET-CT, developing S...
A Novel Immune-Modulating Nanodrug Enhances Liver-Targeted mRNA Delivery [0.03%]
一种新型免疫调节纳米药物可增强肝脏靶向性mRNA传递
Daniel Luo,Dandan Guo,Minghao Luo et al.
Daniel Luo et al.
Liver-specific delivery of mRNAs encoding key regulatory genes via lipid nanoparticles (LNPs) is promising to restore liver homeostasis and resume liver functions in inflammatory liver diseases. However, inflammation downregulates the globa...
Development and Preliminary Evaluations of a Novel 18F-Labeled Tracer for Detection of BRAFV600E Mutant Status in Animal Models of Melanoma [0.03%]
一种新型氟-18标记示踪剂的开发及其在黑色素瘤动物模型中检测BRAF V600E突变状态的初步评估研究
Yiming Guo,Ze Wang,Yingfang He et al.
Yiming Guo et al.
The BRAFV600E mutation is a well-established oncogenic driver, and several oral inhibitors have achieved clinical success. However, radiolabeled tracers for the non-invasive imaging of this mutation remain limited. N-(2-Chloro-3-((3,5-dimet...
Drug-Polymer Interactions and Molecular Miscibility in Amorphous Solid Dispersions: The Duality of Hydrogen Bond-Donor Groups [0.03%]
药物与聚合物的相互作用及无定型固体分散中的分子互溶性：氢键供体基团的双重性
Lennert Cools,Elien Derveaux,Felien Reniers et al.
Lennert Cools et al.
Hydrogen bonds (H-bonds) can have a critical impact on the stability and drug release characteristics of amorphous solid dispersions (ASDs). Based on the structure of the ASD components, it remains however difficult to predict the strength ...
An Estrogen Receptor α-Targeted NIR-II Probe for Breast Tumor Imaging and Image-Guided Surgery [0.03%]
一种用于乳腺肿瘤成像和图像引导手术的雌激素受体α靶向近红外二区探针
Danxia Xu,Lixin Wang,Zilin Tang et al.
Danxia Xu et al.
Breast cancer (BC) is a serious health threat to women worldwide and is on the steady rise in morbidity and mortality, of which estrogen receptor α (ERα)-positive cases account for nearly 70%. ERα is highly expressed in ERα-positive (ER...
Endoplasmic Reticulum Mediates Prolonged Tumor Retention of FAPI Radioconjugates and Enhanced Radiotherapeutic Efficacy [0.03%]
内质网介导的FAPI放射缀合物肿瘤长效滞留和增强的放疗疗效
Guoyu Wang,Fanglei Zhang,Daojia Liu et al.
Guoyu Wang et al.
Radiolabeled fibroblast activation protein inhibitors (FAPIs) face a critical challenge in radionuclide therapy due to their short tumor retention. While existing strategies to prolong retention are often limited in clinical translation, we...
NMR Crystallography at 1 GHz: Insight into a Rich World of Binary Forms of Meloxicam [0.03%]
一吉赫兹核磁共振晶体学：美洛昔康二元形式丰富世界的洞察
Przemysław Nowak,Agata Jeziorna,Marcin Oszajca et al.
Przemysław Nowak et al.
NMR crystallography, which is based on both diffraction- and solid-state NMR-based observables, can deliver a precise description of the crystal structure of powdered samples of pharmaceuticals. On the other hand, it is by no means a straig...
Synthesis and Evaluation of 64Cu-Labeled Small-Size Antibody Fragments for Immuno-PET Imaging of Thyroid-Stimulating Hormone Receptor in Thyroid Cancer [0.03%]
合成和评价64Cu标记的小尺寸抗体片段用于甲状腺癌中促甲状腺激素受体的免疫PET成像研究
Wenhui Fu,Ephraim E Parent,Joshua A Knight et al.
Wenhui Fu et al.
The thyroid-stimulating hormone receptor (TSHR) is a promising molecular target for thyroid cancer imaging and therapy. Our previous work has demonstrated that PET imaging with the radiolabeled anti-TSHR human monoclonal antibody K1-70 enab...
Paeoniflorin-Copper-Coordinated Nanoparticles Targeting Dual Organelles Induce Lung Cancer Apoptosis [0.03%]
芍药苷-铜纳米颗粒靶向双重细胞器诱导肺癌凋亡
Jiachang Lin,Pei Huang,Yongqi Wang et al.
Jiachang Lin et al.
The intrinsic resistance of tumor cells to apoptosis frequently results in chemoresistance and therapeutic failure in clinical settings. The main active ingredients of traditional Chinese medicine, in combination with chemotherapy drugs, ha...