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Endoplasmic Reticulum Mediates Prolonged Tumor Retention of FAPI Radioconjugates and Enhanced Radiotherapeutic Efficacy

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Radiolabeled fibroblast activation protein inhibitors (FAPIs) face a critical challenge in radionuclide therapy due to their short tumor retention. While existing strategies to prolong retention are often limited in clinical translation, we hypothesized that t... ...