Construction of a 89Zr-Labeled Specific Antibody Fragment for the Noninvasive Detection of Mesothelin-Overexpressing Tumors [0.03%]
用于检测 mesothelin 过度表达肿瘤的放射性药物89Zr标记抗体片段的制备
Xingguo Hou,Lulin Yang,Futao Liu et al.
Xingguo Hou et al.
Numerous clinical trials on mesothelin (MSLN)-targeted antibodies have provided preliminary evidence supporting their clinical translation, highlighting the importance of patient screening. Although anti-MSLN chimeric antigen receptor T (CA...
Controlling the Size and Shape of Monoclonal Antibody Particles through Crystallization Process Design [0.03%]
通过结晶过程设计控制单克隆抗体颗粒的大小和形状
L Codan,P Larpent,R Kalapos-Dobszay et al.
L Codan et al.
The crystallization of monoclonal antibodies is deemed particularly challenging due to their large size and structural flexibility. An additional challenge is represented by the tendency of mAb crystals to rapidly lose their crystallinity w...
Correction to "Detection of Voltage-Gated Potassium Channels 1.3 via Immuno-PET Visualizes Rheumatoid Arthritis" [0.03%]
对“通过免疫PET检测电压门控钾通道1.3可视化类风湿关节炎”的勘误
Sixuan Cheng,Youzhuo Quan,Xingru Long et al.
Sixuan Cheng et al.
Published Erratum
Molecular pharmaceutics. 2026 May 11. DOI:10.1021/acs.molpharmaceut.6c00500 2026
Integrating PET and Fluorescence Imaging with a Novel PSMA-ICG Conjugate for Prostate Cancer Management [0.03%]
用于前列腺癌管理的新型PSMA-ICG缀合物整合正电子发射断层扫描和荧光成像技术
Jiale Hou,Liying Tang,Ming Zhou et al.
Jiale Hou et al.
Prostate cancer (PCa) is a major global health burden, but current preoperative imaging modalities lack sufficient sensitivity for precise diagnosis. Thus, developing efficient novel imaging probes is urgently needed to improve PCa diagnosi...
Multinuclear Solid-State NMR and NMR Crystallography of Solid Forms of Creatine and Creatinine [0.03%]
creatine和creatinine固体形式的多核固态NMR及NMR晶体学研究
Carl H Fleischer rd,Victoria K Rash,Zach T Dowdell et al.
Carl H Fleischer rd et al.
Creatine is a performance-enhancing supplement with two widely available commercial solid forms, namely, creatine monohydrate (creatine·H2O) and creatine HCl, the latter of which does not have a reported crystal structure. Moreover, commer...
Water-Stable Hydrazone-Linked Porous Organic Cage-Enhanced Nanoparticle Brachytherapy for the Treatment of Glioblastoma [0.03%]
一种水稳定的腙连接型多孔有机笼增强型纳米粒子近距离放射疗法治疗胶质母细胞瘤的方法
Junqiang Dai,Kongzhao Su,Zhenhua Song et al.
Junqiang Dai et al.
Radiotherapy has played a crucial role in the treatment of glioblastoma (GBM). Continuous advancements have aimed to maximize radiation delivery to tumor regions while minimizing injury to the surrounding healthy tissues. Recently, local br...
VEGFA-Targeted M3-F4 Ionizable Lipid Nanoparticles Improve Diabetic Retinopathy [0.03%]
针对VEGFA的M3-F4离子脂质纳米颗粒可改善糖尿病视网膜病变
Suyu Liu,Yanbo Bao,Yilinuer Yilihaer et al.
Suyu Liu et al.
Diabetic retinopathy (DR) is one of the leading causes of visual impairment and blindness worldwide. Current therapies for DR primarily focus on inhibiting vascular endothelial growth factor A (VEGFA); however, their efficacy remains limite...
Potential of Low-Frequency Raman Spectroscopy for Structural Screening of Lipid-Based Drug Delivery Systems for Poorly Water-Soluble Drugs [0.03%]
低频拉曼光谱技术在脂质药物递送系统结构筛查中的应用潜力研究
Ka̅rlis Be̅rziņš,Lasse S Krog,Ben J Boyd
Ka̅rlis Be̅rziņš
Dynamic changes in the structure of lipid lyotropic liquid crystals upon mixing of different lipid systems were investigated using simultaneous low-frequency Raman (LFR) and small-angle X-ray scattering (SAXS) at a synchrotron facility. Mon...
Estimation of Various Physiological Parameters Affecting Amyloid Plaque Distribution of a Novel MRI Contrast Agent in the Brain of Alzheimer's Disease Transgenic Mice [0.03%]
阿尔茨海默病转基因小鼠脑内新型MRI对比剂影响淀粉样斑块分布的各生理参数估计
Vrishali Salian,Zengtao Wang,Geoffry Curran et al.
Vrishali Salian et al.
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptides as plaques in the brain parenchyma and as deposits in the cerebral vasculature. Early detection of amyloid plaques and deposits is imperative for dia...
The In Vivo Effect of Amorphous Drug Nanoprecipitates on the Intestinal Absorption of the PROTACs ARV-110 (Bavdeglutamide) and ARV-471 (Vepdegestrant) [0.03%]
PROTACs药物ARV-110（Bavdeglutamide）和ARV-471（Vepdegestrant）的无定形纳米沉淀物对肠道吸收的体内影响
Janis Niessen,Mirko Koziolek,Anura Indulkar et al.
Janis Niessen et al.
Targeted degradation of disease-associated proteins via proteolysis-targeting chimeras (PROTACs) is a powerful pharmacological strategy, but it requires a complex molecular architecture associated with poor intestinal absorption. Rational d...