Macropa-Based 225Ac-Labeled RGD Peptides for Targeted Alpha Therapy [0.03%]
一种基于Macropa的225Ac标记RGD肽用于靶向α治疗
Hiroaki Echigo,Masayuki Munekane,Takeshi Fuchigami et al.
Hiroaki Echigo et al.
Macropa has formed more stable complexes with 225Ac, although DOTA has been extensively used as a chelator for 225Ac. This study aimed to design and synthesize two novel 225Ac-labeled RGD peptides, [225Ac]Ac-Macropa-c(RGDyK) ([225Ac]1) and ...
Correction to "d-α-Tocopherol Polyethylene Glycol Succinate-Based Redox-Sensitive Paclitaxel Prodrug for Overcoming Multidrug Resistance in Cancer Cells" [0.03%]
关于“基于d-α-生育酚聚乙二醇琥珀酸的红氧敏感紫杉醇前药克服癌细胞多重耐药”的更正论文
Yuling Bao,Yuanyuan Guo,Xiangting Zhuang et al.
Yuling Bao et al.
Published Erratum
Molecular pharmaceutics. 2026 Jul 27. DOI:10.1021/acs.molpharmaceut.6c00984 2026
Primary Packaging Hydrophilicity/Hydrophobicity: A Critical Factor Governing Visible-Bubbles during Reconstitution Process of Lyophilized High-Concentration Monoclonal Antibody Formulations [0.03%]
用于高浓度单克隆抗体冻干制剂配制过程中可见气泡控制的 primary 包装容器的关键润湿性因素的影响研究
Han Gao,Zhao-Lin Ding,Jun Ouyang et al.
Han Gao et al.
Driven by the evolving demands of modern pharmaceutical industry, high-concentration monoclonal antibody formulations (HCMFs) have emerged as a central research hotspot in biopharmaceutical development, attributable to their merits such as ...
Relaxation Processes in Freeze-Dried Monoclonal Antibody-Sucrose Formulations: The Role of Water Content [0.03%]
冻干单克隆抗体蔗糖配方中水分含量对解吸过程的影响研究
N S Krishna Kumar,Zhiyi Lin,Cole W Tower et al.
N S Krishna Kumar et al.
Residual water in freeze-dried protein formulations plays a critical role in molecular relaxation behavior. In a previous study (Kumar et al., Mol Pharmaceutics 2025, 22, 4125-4136), we examined the impact of sucrose concentration on native...
Radiosynthesis and Preclinical Evaluation of Enantiopure (R)-[18F]Fluorolactate for PET Imaging of Metabolic Processes [0.03%]
光学纯(R)-[18F]氟乳酸的放射合成及其代谢成像的药代动力学研究
Xiaoqing Zhuang,Jenni Virta,Negar A Samani et al.
Xiaoqing Zhuang et al.
L-Lactate is a key substrate in energy metabolism and a potential biomarker for cancer and metabolic disorders. We developed an enantiomerically pure positron emission tomography (PET) tracer, (R)-[18F]fluorolactate, to mimic natural L-lact...
Auger Electron Therapy Enhanced by Heat-Triggered Release of I-125-Labeled DNA-Targeted Compounds within the Tumor Microenvironment [0.03%]
由热触发释放DNA靶向化合物内的I-125标记物增强奥尔加电子治疗
Masayuki Munekane,Kazuki Matsunaga,Miki Ozaki et al.
Masayuki Munekane et al.
In Auger electron therapy, the effective delivery of Auger electron-emitting radionuclides to the nuclei of cancer cells is essential for achieving high therapeutic efficacy. In this study, we developed a novel strategy that combined thermo...
Intracellular Delivery of Full-Length Antibodies via Poly-l-lysine-Coated PEG-PLGA Polymersomes Enables Noninvasive Pulmonary Immunotherapy [0.03%]
聚乙二醇(plga)聚合物囊泡表面包覆聚-l-赖氨酸负载全抗体实现非侵入性肺部免疫疗法
Vida Nazar,Lincoln Paul Buxton,Sui Jiang et al.
Vida Nazar et al.
The intracellular delivery of full-length antibodies offers substantial therapeutic potential but remains limited by poor cellular uptake, extracellular degradation, and inefficient encapsulation strategies. Here, we report a noninvasive, s...
Xin Yao,Mengqi Yu,Fei Chen et al.
Xin Yao et al.
Pharmaceutical salts are commonly used to enhance the bioavailability of poorly water-soluble drugs. The maximum solubility in water and the physical stability of a salt are closely linked to its pHmax, the pH at which both the free form (a...
PET Imaging of Phosphorylated RIPK1 Reveals Necroptosis Activation In Vivo [0.03%]
体内磷酸化RIPK1的正电子发射断层显像揭示坏死性凋亡激活
Sun Mi Park,Tae Sup Lee,Jieun Lee et al.
Sun Mi Park et al.
Necroptosis is a regulated, pro-inflammatory form of programmed cell death implicated in degenerative and inflammatory diseases, with RIPK1 acting as a key upstream regulator. However, the utility of existing RIPK1 PET radiotracers, as well...