Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy [0.03%]
订正：肝细胞IRE1α-XBP1信号通路促进化疗介导的生长分化因子15产生引起的厌食和体重减轻反应
Yuexiao Tang,Tao Yao,Xin Tian et al.
Yuexiao Tang et al.
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosis [0.03%]
JAK2/JAK2V617F异二聚体通过激活STAT1和AhR促进血小板增多症
Radek C Skoda,Olli Silvennoinen
Radek C Skoda
In this issue of JEM, Zhou et al. (https://doi.org/10.1084/jem.20250153) report that hematopoietic progenitors heterozygous for the JAK2V617F mutation preferentially activate STAT1, promoting platelet production and thrombocythemia, whereas...
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine [0.03%]
GPR34和溶血磷脂酰丝氨酸促进脾脏cDC1的凋亡细胞吞噬作用及交叉呈递活化CD8T细胞
Hanson Tam,Haolin Shen,Ying Xu et al.
Hanson Tam et al.
Spleen conventional dendritic cells type 1 (cDC1) take up apoptotic cells (AC) and cross-present associated antigens to CD8 T cells. The receptors promoting AC uptake are incompletely defined. Here, we tested the function of GPR34, a recept...
Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice [0.03%]
补充附录：蛋白精氨酸甲基转移酶1在小鼠生发中心阳性选择后调节B细胞命运
Ludivine C Litzler,Astrid Zahn,Kiersten L Dionne et al.
Ludivine C Litzler et al.
The assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumor immunity [0.03%]
长链非编码RNA LISRR通过组装癌特异性核糖体来抑制黑色素瘤的抗肿瘤免疫作用
Sonia Cinque,Yvessa Verheyden,Sara Adnane et al.
Sonia Cinque et al.
Gains of chromosome 12p11.21, encoding for the cancer-specific lncRNA LISRR, correlate with poor survival across different cancers. In melanoma, LISRR is upregulated in immunotherapy-resistant patients to contribute to the generation of dru...
Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function [0.03%]
放射治疗通过诱导树突细胞中YTHDF2的表达从而影响交叉呈递和T细胞的功能
Dapeng Chen,Liangliang Wang,Chuangyu Wen et al.
Dapeng Chen et al.
Metastatic progression is a major cause of radiotherapy (RT) failure, yet the mechanisms linking RT to immune suppression and metastasis remain unclear. Here, we identify YTHDF2 as a radiation-induced immune checkpoint in dendritic cells (D...
Esther Obeng: It's exciting to tackle questions that don't yet have answers [0.03%]
埃斯特·奥彭：解答那些尚未破解的问题令人兴奋
Lucie Van Emmenis
Lucie Van Emmenis
Esther Obeng is an attending physician and associate professor at Emory University School of Medicine, where she leads a research group focused on myelodysplastic syndromes (MDS). Esther's team is investigating how normal hematopoietic stem...
Transcriptomics- and 3D imaging-based characterization of the lymphatic vasculature in human skin [0.03%]
基于转录组和三维成像的人类皮肤淋巴管血管的特征描述
Aline Bauer,Lito Zambounis,Ioannis Kritikos et al.
Aline Bauer et al.
Afferent lymphatic vessels (LVs) are present in most vascularized tissues and exert important immune and drainage functions, yet human afferent LVs remain poorly studied. Performing single-cell RNA sequencing of lymphatic endothelial cells ...
Xbp1 controls the reparative function of intestinal ILC2s during colitis [0.03%]
肠炎期间Xbp1控制肠道ILC2s的修复功能
Yanyan Cui,Zixiao Zhao,Jing Shen et al.
Yanyan Cui et al.
Ulcerative colitis (UC) is primarily characterized by inflammation-induced tissue damage, but impaired tissue repair also drives disease progression. This study demonstrates group 2 innate lymphoid cells (ILC2s), key players in tissue repai...
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms [0.03%]
异源黏膜疫苗加强可分别通过不同的机制增强黏膜和全身免疫反应
Cameron Bissett,Lyn Yong,Alexandra J Spencer et al.
Cameron Bissett et al.
Seasonal booster vaccination is the primary intervention for protection from respiratory viral infections, such as influenza virus or SARS-CoV-2. However, efficacy is often limited because immune exposure to prior strains impairs developmen...