Cansu Yerinde,Debattama Rai Sen
Cansu Yerinde
Song et al. (https://doi.org/10.1084/jem.20250424) identify Mettl8 as a regulator of progenitor exhausted CD8+ T cells, stabilizing Tcf7 transcripts and shaping chromatin programs. Mettl8 loss drives effector differentiation and improves tu...
AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells [0.03%]
AID和TET2合作去甲基化Irf4以决定生发中心B细胞向浆细胞分化的命运
Minghui He,Roberta D&#x;Aulerio,Lia G Pinho et al.
Minghui He et al.
Activation-induced cytidine deaminase (AID) is essential for B cell affinity maturation. We investigated why AID deficiency gives rise to giant germinal centers (GCs) using the AIDR112H mouse model that is devoid of AID activity. The increa...
IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens [0.03%]
异乎寻常的记忆B细胞和浆细胞中的IgD targeting作用于共生及环境抗原
Roser Tachó-Piñot,Habib Bashour,Martyna Filipska et al.
Roser Tachó-Piñot et al.
Human tonsils from the nasopharyngeal mucosa mount frontline antibody responses, including IgD secretion by IgD+IgM- plasma cells (IgD-PCs). The developmental origins and functional significance of these IgD responses remain poorly understo...
Kim L Good-Jacobson
Kim L Good-Jacobson
The nasopharyngeal tissues provide a frontline defense against airborne exposure to viruses, bacteria, and allergens. In this issue of JEM, Tachó-Piñot et al. (https://doi.org/10.1084/jem.20251752) show that mutated IgD+ B cell subsets po...
B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine [0.03%]
B7共刺激作用于肠道RORγt+调节性T细胞和免疫耐受
Mengze Lyu,Gregory F Sonnenberg
Mengze Lyu
Regulatory T (Treg) cells that recognize dietary- or microbiota-derived antigens express RORγt and are essential for immune tolerance in the intestine. A recent paradigm shift found these cells require major histocompatibility complex clas...
CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β [0.03%]
CD163和Tim-4识别常驻肠巨噬细胞并由TGF-β空间调控
Vignesh Jayaraman,Ian E Prise,Verena Kästele et al.
Vignesh Jayaraman et al.
Macrophages localize in sub-tissular niches associated with their ontogeny and activity. In the intestine, a paradigm has emerged that long-lived macrophages are present in the muscular layer, while highly monocyte-replenished populations a...
Signals in space: TGF-β defines where and what gut macrophages become [0.03%]
空间信号：TGF-β确定肠巨噬细胞的定位与命运
Camille Blériot,Florent Ginhoux
Camille Blériot
Macrophages are profoundly shaped by their tissue of residence. In this issue, Jayaraman et al. (https://doi.org/10.1084/jem.20240801) show that TGF-β signaling is crucial for maintaining the identity, function, and spatial organization of...
Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas [0.03%]
肺部真菌肉芽肿中，可交替激活的单核细胞来源髓样细胞促进胞外病原菌持续存在
Yufan Zheng,Makheni Jean Pierre,Eduard Ansaldo et al.
Yufan Zheng et al.
Inhaled fungal pathogens often generate granuloma-contained latent infections that can reactivate to cause invasive disease. However, why protective pathways fail to achieve sterilizing immunity in this setting is unclear. Here, we identify...
Matthew R Hepworth,Richard K Grencis
Matthew R Hepworth
In this issue of JEM, Forster et al. (https://doi.org/10.1084/jem.20250781) report that Blimp-1 is a pivotal alarmin-activated transcription factor that is critical in controlling optimal effector cytokine secretion in ILC2 cells during typ...
Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza [0.03%]
鼻黏膜CD4+组织驻留记忆T细胞对流感的交叉保护作用
Nimitha R Mathew,Romain Gailleton,Lydia Scharf et al.
Nimitha R Mathew et al.
CD4 tissue-resident memory T cells (TRM) are crucial adaptive immune components involved in preventing influenza A virus (IAV) infection. Despite their importance, their physiological role in the upper respiratory tract, the first site of c...