AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells
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Activation-induced cytidine deaminase (AID) is essential for B cell affinity maturation. We investigated why AID deficiency gives rise to giant germinal centers (GCs) using the AIDR112H mouse model that is devoid of AID activity. The increased GC response was ... ...
