Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis [0.03%]
Tet2缺陷通过促进单核细胞源性巨噬细胞的扩增参与肝纤维化的发展
Jiuxing Feng,Baitong Wu,Yu Li et al.
Jiuxing Feng et al.
Clonal hematopoiesis driven by Tet2 deficiency in myeloid cells (TetΔMye) is prevalent in elderly individuals; however, the role of Tet2ΔMye in liver fibrosis pathogenesis remains elusive. In this study, we demonstrated that Tet2-deficien...
ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense [0.03%]
ERADP通过促进潘氏细胞致密核心囊泡的生物发生来增强肠道防御能力
Cunzhen Li,Zhen Xiong,Deyuan Kong et al.
Cunzhen Li et al.
Paneth cells secrete antimicrobial peptides (AMPs) to modulate composition of gut microbiota and host defense. AMPs are typically packaged into dense core vesicles (DCVs) and secreted into the intestinal lumen. However, the mechanisms under...
P A Baeuerle,K Sauer,R Grieshaber-Bouyer et al.
P A Baeuerle et al.
T cell engagers (TCEs) are antibody-based constructs designed to transiently reprogram cytotoxic T lymphocytes for target cell elimination by simultaneously binding the T cell receptor and a specific surface antigen on the target cell. Over...
Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis [0.03%]
Correction: REV-ERB通过Bhlhe40-c-Maf轴调节RORγt+调节性T细胞的谱系归命和功能
Xianting Hu,Zhi Liu,Yao Li et al.
Xianting Hu et al.
Marjorie Cayatte,Valentin Picant,Marie Vétizou et al.
Marjorie Cayatte et al.
Natural killer (NK) cells are cytotoxic and cytokine-producing innate lymphocytes with established roles in antiviral and antitumor immunity. In recent years, the biology of NK cells has been exploited in innovative cancer immunotherapies, ...
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis [0.03%]
FIP200通过线粒体和血红素稳态调控浆细胞分化
Liling Xu,Maria Bottermann,Paula M Villavicencio et al.
Liling Xu et al.
Little is known about the role of autophagy in the human humoral immune system. Here, we found that in B cells, genetic ablation of FIP200, a mammalian metabolic sensor that regulates autophagy in response to a range of stimuli, led to dimi...
Antibiotic use in early life impairs MAIT cell-mediated immunity in adulthood [0.03%]
生命早期使用抗生素损害成人时期的MAIT细胞介导的免疫功能
Gabrielle R LeBlanc,Adam L Sobel,Jonathan Melamed et al.
Gabrielle R LeBlanc et al.
Mucosal-associated invariant T (MAIT) cells are predominantly located in barrier tissues where they rapidly respond to pathogens and commensals by recognizing microbial derivatives of riboflavin synthesis. Early-life exposure to these metab...
HIF-1-mediated ISG20 expression promotes breast cancer stemness and immune evasion [0.03%]
HIF-1介导的ISG20表达可促进乳腺癌干细胞特性及免疫逃逸
Yongkang Yang,Qiaozhu Zuo,Vijay Ramu et al.
Yongkang Yang et al.
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the highest rates of recurrence, metastasis, and patient mortality due to the absence of effective therapies. Hypoxia-inducible factor 1 (HIF-1) regulate...
Alejandra Aroca-Crevillén,Sandra Martín-Salamanca,Lidiane S Torres et al.
Alejandra Aroca-Crevillén et al.
Inflammation-driven injury, a significant source of morbidity and mortality worldwide, is largely mediated by the cytotoxic activities of neutrophils, which extend the initial lesion and jeopardize organ function. Intriguingly, inflammatory...
Ryan A Langlois
Ryan A Langlois
Fever is an evolutionarily conserved response to infection that emerged ∼600 million years ago, providing survival benefits across diverse taxa from insects to mammals. While fever's protective mechanisms include moving pathogens outside t...