Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion [0.03%]
撤回：TSC突变肿瘤通过NRF2和谷胱甘肽耗竭对CDK7抑制敏感
Mahsa Zarei,Heng Du,Amin H Nassar et al.
Mahsa Zarei et al.
Ross W Ward,Uddipan Kar,Sreekumar Balan et al.
Ross W Ward et al.
Conventional type 1 dendritic cells (cDC1s) promote antitumor immunity through efficient cross-presentation of tumor antigens and production of key mediators. Crucially, in the tumor microenvironment, cDC1s orchestrate immune hubs and signa...
BCL6 is required for the development of functionally responsive IgM+ GC Tfh-independent memory B cells [0.03%]
BCL6对于IgM+生发中心Tfh非依赖的记忆B细胞的发展及功能应答是必需的
Gretchen Harms Pritchard,Akshay T Krishnamurty,Lauren B Rodda et al.
Gretchen Harms Pritchard et al.
Humoral immunity depends upon long-lived, antibody-secreting plasma cells and memory B cells (MBCs). MBCs exhibit significant phenotypic and functional heterogeneity shaped by interactions with CD4+ T cells. It is currently unclear how spec...
Bidirectional regulation by BACH2 coordinates systemic CXCR5- vs. CXCR5+ CD4+ T cell differentiation [0.03%]
BACH2的双向调控协调系统性CXCR5-和CXCR5+CD4+T细胞分化
Andrew R Schroeder,Fangming Zhu,Xianyou Xia et al.
Andrew R Schroeder et al.
CD4+ T cells differentiate into T follicular helper (Tfh) and non-Tfh cells, helping regulate humoral and cellular responses. Here, we show that in robust CD4+ T cell responses, all early CXCR5+CD4+ T cells expressed CD25, and STAT5, which ...
eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy [0.03%]
eIF3e介导的翻译检查点可维持免疫耐受并防止淋巴瘤发生
Lianghua Lin,Pengda Chen,Jiazhen Wang et al.
Lianghua Lin et al.
Translational control is essential for immune function, but its roles in immune tolerance and lymphomagenesis remain poorly defined. Here, we show that Cγ1Cre-mediated deletion of Eif3e, which encodes a subunit of the eIF3 translation init...
A signal-responsive cooperative transcription factor network determines alveolar macrophage identity [0.03%]
一种响应信号的协同转录因子网络决定肺泡巨噬细胞的身份
Jorge Mínguez-Martínez,Jesús Porcuna,Laura Casablanca et al.
Jorge Mínguez-Martínez et al.
Tissue-resident macrophages receive signals from their microenvironment that coordinate the activity of transcription factors (TFs) to establish distinct transcriptional profiles and identities. However, the molecular mechanisms whereby int...
Cathepsin S regulates germinal center reactions and anti-tumor humoral responses [0.03%]
猫hepsin S调节生发中心反应和抗肿瘤体液免疫反应
Marine Bruand,Divyanshu Srivastava,Aaron Petruzzella et al.
Marine Bruand et al.
B cells mature into antibody-secreting cells by antigen processing and presentation and undergo productive germinal center (GC) reactions in secondary lymphoid organs. In solid tumors, antigen presentation and local anti-tumor humoral immun...
Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments [0.03%]
血管水通道蛋白-1在高渗炎症微环境下的淋巴管生成中的作用
Irena Roci,Jaeryung Kim,Kelly de Korodi et al.
Irena Roci et al.
Intestinal lymphatic vessels are essential for dietary lipid absorption and immune cell trafficking. Villus lymphatic capillaries, lacteals, undergo continuous VEGF-C-dependent renewal to function in a hyperosmolar, inflammatory environment...
A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer [0.03%]
正向遗传学筛选鉴定出Sirtuin1是神经内分泌前列腺癌的驱动因子
Francisca Nunes de Almeida,Alessandro Vasciaveo,Arianna Giacobbe et al.
Francisca Nunes de Almeida et al.
Although most prostate tumors are relatively indolent, advanced disease can progress to aggressive, often lethal variants, including neuroendocrine prostate cancer (NEPC). To identify drivers of aggressive prostate cancer, we used Sleeping ...
Søren R Paludan,Sara Cherry
Søren R Paludan
Hantavirus disease illustrates the complexity of infectious diseases and puts spotlight on the need to understand the processes driving pathology and those that can prevent or mitigate disease. This Viewpoint argues that improved treatments...