Luca Frosio,Renato Ostuni
Luca Frosio
Innate immune cells can retain molecular imprints of past encounters long after the initial stimulus has ceased. In this issue, Gorin et al. (https://doi.org/10.1084/jem.20250976) reveal an unexpected mechanism by which IFN-γ sustains trai...
Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2 [0.03%]
关于针对乳糜泻自身抗原组织型转谷氨酰胺酶2的B细胞耐受性和抗体产生的更正通知
M Fleur du Pré,Jana Blazevski,Alisa E Dewan et al.
M Fleur du Pré et al.
Correction: Contribution of IL-17-producing γδ T cells to the efficacy of anticancer chemotherapy [0.03%]
关于IL-17分泌的γδT细胞对抗癌化疗疗效贡献的更正通知
Yuting Ma,Laetitia Aymeric,Clara Locher et al.
Yuting Ma et al.
Follow the "DOTs": Vδ1+ γδ T cells as effectors of cancer immunotherapy [0.03%]
循“DOT”而上：Vδ1γδ T 细胞在癌症免疫治疗中的作用
Bruno Silva-Santos,Sofia Mensurado,Rafael Blanco-Domínguez et al.
Bruno Silva-Santos et al.
Cancer immunotherapy has mostly relied on conventional T cells to achieve success in a limited set of tumor types. A promising avenue to expand the repertoire of cancers effectively treated through immune intervention is to mobilize other a...
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity [0.03%]
肝X受体激动促进T细胞活化并增强抗肿瘤免疫反应
Benjamin N Ostendorf,Jonathan G Goldstein,Shuang Liu et al.
Benjamin N Ostendorf et al.
Many cancer patients do not benefit from current immunotherapies. This lack of efficacy may be, in part, due to insufficient priming and activation of T cells. Here, we show that activation of liver-X-receptors (LXRs) promotes adaptive anti...
Nasal germinal centers and IgA class-switch recombination depend on CCR6 and B cell receptor affinity [0.03%]
鼻咽生发中心和IgA类别转换重组依赖CCR6和B细胞受体亲和力
Jingjing Liu,Liat Stoler-Barak,Ziv Shulman
Jingjing Liu
Antibody-mediated immune responses in mucosal tissues are critical for defending against pathogens while maintaining homeostasis with commensals. Nasal vaccination aims to induce local protection in the upper airway mucosa. Although B cell-...
Birui Pan,Qinli Sun,Ruifeng Li et al.
Birui Pan et al.
In the tumor microenvironment (TME), "exhausted" CD8+ T cells are classified into progenitor (Tpex) and terminally exhausted (Ttex) populations. Tpex cells, critically regulated by zinc finger and BTB domain containing 27 (Zbtb27)/Bcl6 tran...
Correction: Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function [0.03%]
纠正：尼古丁通过极化小胶质细胞并抑制先天性免疫功能促进脑转移
Shih-Ying Wu,Fei Xing,Sambad Sharma et al.
Shih-Ying Wu et al.
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells [0.03%]
DOCK8和STAT3合作抑制诱导IgE的滤泡辅助性T细胞
Emily R Siniscalco,Courtney Fisher,Meng-Ping Lu et al.
Emily R Siniscalco et al.
Patients with loss-of-function DOCK8 or dominant-negative STAT3 variants have hyper-IgE syndrome, although only DOCK8 deficiency consistently presents with elevated food-specific IgE and symptomatic allergy. We previously found in mice that...
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers [0.03%]
表观遗传和代谢重编程支持生发中心浆细胞分化
Yuliang Wang,Xinyi Yang,Mengting Lou et al.
Yuliang Wang et al.
The germinal center (GC) is a specialized structure that ensures the production of high-quality antibodies. Although recent studies have pinpointed the existence of a pre-plasma cell (prePC) population within mouse GC B cells, it remains un...