Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2) [0.03%]
STAT2(TIMS2)基因突变导致的家族性肺泡蛋白沉积症和I型干扰素病
Conor Gruber,Meredith Ramba,Bineeta Debnath et al.
Conor Gruber et al.
Mutations that enhance type I interferon (IFN-I) activity cause monogenic autoinflammatory disorders termed type I interferonopathies. Along with the typical neurologic and rheumatologic manifestations, severe pulmonary disease is increasin...
Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis [0.03%]
罕见或常见的IL23R低功能纯合变异易患结核病
Diana Olguín Calderón,Laura E Kilpatrick,Clément Conil et al.
Diana Olguín Calderón et al.
Homozygosity for rare loss-of-function IL23R variants abolishes IL-23-dependent IFN-γ production by lymphocytes, including NK and innate-like T cells, thereby underlying clinical disease due to weakly virulent mycobacterial species. We rep...
ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype [0.03%]
ADAR1功能丧失型变异体改变RNA编辑定义了一种新的干扰素依赖型银屑病亚型
Florence Assan,Margot Tragin,Sahiti Marella et al.
Florence Assan et al.
Recent evidence implicates altered RNA editing and dysregulated type I IFN signaling in immune-mediated diseases, including psoriasis, although the underlying genetic mechanisms remain poorly defined. We investigated four unrelated multiple...
Both soluble and cell surface CD137 expressed by Foxp3+ CD4 T cells restrain autoimmune diabetes [0.03%]
Foxp3阳性CD4 T细胞所表达的可溶性和细胞表面CD137均能抑制自身免疫糖尿病
Rabia Nabi,Chien-Wei Lin,Yu Wang et al.
Rabia Nabi et al.
CD137 is expressed in a subset of Foxp3+ regulatory CD4 T cells (Tregs), but its immunoregulatory role is not fully defined. Due to alternative splicing that removes the transmembrane domain-encoding exon, CD137 exists in both membrane and ...
Aeson Chang,Shenghong Zhu,Terrance Lam et al.
Aeson Chang et al.
The nervous system has emerged as a critical regulator of cancer progression. Recent studies demonstrate that peripheral neurons shape tumor growth, dissemination, and therapeutic response by regulating multiple components of the tumor micr...
Ivan Zanoni
Ivan Zanoni
Type III IFNs, or IFNλ, are pleiotropic immune mediators that mostly work at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang, and colleagues (https://doi.org/10.1084/jem.20251858) demonstrate that I...
Jinfang Zhu
Jinfang Zhu
In this issue of JEM, Schroeder et al. (https://doi.org/10.1084/jem.20251959) report that the transcription factor BACH2 has context-dependent dual functions in regulating the differentiation of follicular T helper cells. ...
Bridging veins govern discrepancy of CSF efflux into dura mater in mice [0.03%]
小鼠脑脊液流入颅骨内膜的差异由桥静脉调控
Lingli Yan,Senthil Kumaran Satyanarayanan,Di Huang et al.
Lingli Yan et al.
Meningeal lymphatic vessels within the dura provide a route for cerebrospinal fluid (CSF) outflow, but how CSF crosses the arachnoid barrier, particularly toward basal dural compartments, remains unclear. Using in vivo CSF tracer infusion a...
Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation [0.03%]
嵌合过敏受体调节性T细胞可抑制桦树花粉引起的过敏性气道炎症
Ana Alcaraz-Serna,Noémie Chillier,Aurélien Trompette et al.
Ana Alcaraz-Serna et al.
Asthma is a deadly chronic respiratory disease affecting over 300 million people. While allergen immunotherapy remains the only disease-modifying treatment, it is poorly applicable for patients with severe asthma. Here, we explored the ther...
Interferon-λ drives renal fibrosis by coordinating epithelial-fibroblast crosstalk [0.03%]
干扰素-λ通过协调上皮细胞-纤维母细胞相互作用促进肾纤维化
Yunfeng Zhou,Ying Zhang,Miao Zhu et al.
Yunfeng Zhou et al.
Renal fibrosis is a critical step in chronic kidney disease (CKD) progression, but fibrosis induction is still not understood well. We found that IFN-λ is a profibrotic factor that is upregulated in fibrotic human and mouse kidneys. IFN-λ...