Invariant TCR-triggered protein kinase D activation mediates NKT cell development [0.03%]
不变的TCR触发蛋白激酶D活化介导NKT细胞发育
Eri Ishikawa,Hidetaka Kosako,Daisuke Motooka et al.
Eri Ishikawa et al.
Development of invariant natural killer T (iNKT) cells in the thymus requires cell-cell interaction through invariant TCR (iTCR) and CD1d, which induces expression of the transcription factor, promyelocytic leukemia zinc finger (PLZF). Howe...
DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts [0.03%]
DUX4诱导的基因定义了人类胎盘合胞体中的抗病毒防御程序
Joshua Hatterschide,Liheng Yang,Carolyn B Coyne
Joshua Hatterschide
The placenta combats mother-to-fetus transmission of viruses through the antiviral activities of fetal-derived trophoblasts. Placental trophoblasts employ specialized antiviral strategies to protect against infection while preventing matern...
Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis [0.03%]
进行性多发性硬化动物模型中硬脑膜和骨髓B细胞的动态变化
Alexandra Florescu,Michelle Zuo,Angela A Wang et al.
Alexandra Florescu et al.
In multiple sclerosis (MS), the leptomeninges (LM) are populated with immune cell aggregates that correlate with disease progression. The impact of LM inflammation on the adjacent dura is largely unknown. Using a mouse model of MS that indu...
Women in STEM becoming independent: Asking for help creates opportunities for connections and kindness [0.03%]
女性从事STEM工作变得独立：寻求帮助为自己创造了联系和善意的机会
Michela Frascoli,Dequina Nicholas,Ada Weinstock et al.
Michela Frascoli et al.
Specific loading of oncolytic VSV on CAR enhances CAR-T cell signaling and antitumor activity [0.03%]
特异性加载的溶瘤VSV对CAR的结合可增强CAR-T细胞信号传导和抗肿瘤活性
Fan Xing,Xuemei Wang,Zeying Li et al.
Fan Xing et al.
Oncolytic viruses (OVs) have been shown to increase the efficacy of chimeric antigen receptor (CAR) T cells in treating solid tumors. However, their combined effect has been limited by the unbalanced distribution of two agents in tumor tiss...
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation [0.03%]
自身免疫病风险基因ANKRD55通过代谢调节促进TH17效应功能
Jinjin Xu,Lingjia Kong,Elizabeth A Creasey et al.
Jinjin Xu et al.
Genome-wide association studies (GWAS) have linked the locus encoding ankyrin repeat domain 55 (ANKRD55) with numerous autoimmune diseases; however, its biological function and role in inflammation are unclear. Here, we demonstrate that Ank...
TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming [0.03%]
toll样受体2通过代谢重编程促进γδ T细胞对眼表菌群的IL-17A应答
Wenjie Zhu,Xiaoyan Xu,Vijayaraj Nagarajan et al.
Wenjie Zhu et al.
The ocular surface is a mucosal barrier tissue colonized by commensal microbes, which tune local immunity by eliciting IL-17 from conjunctival γδ T cells to prevent pathogenic infection. The commensal Corynebacterium mastitidis (C. mast) ...
Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state [0.03%]
肠道调节性T细胞维持沙门氏菌超级传播宿主无症状携带状态的机制
Blanda Di Luccia,Liliana M Massis,Daniel S C Butler et al.
Blanda Di Luccia et al.
Host-pathogen interactions involve two critical strategies: resistance, whereby hosts clear invading microbes, and tolerance, whereby hosts carry high pathogen burden asymptomatically. Here, we investigate mechanisms by which Salmonella-sup...
Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn's disease [0.03%]
多组学揭示克罗恩病肠道驻留记忆CD4+t细胞转录程序
Mitsuru Arase,Mari Murakami,Takako Kihara et al.
Mitsuru Arase et al.
Tissue-resident memory T cells (TRM) remain in nonlymphatic barrier tissues for extended periods and are deeply involved in immune memory at the site of inflammation. Here, we employed multilayered single-cell analytic approaches including ...
Lucie Van Emmenis
Lucie Van Emmenis
Sarah Teichmann is a professor at the University of Cambridge, where she leads a research group that uses a combination of genomics, artificial intelligence (AI), and bioinformatics to further understand various aspects of immunity. She is ...