NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation [0.03%]
髓系细胞中由NIK驱动的IL-23生成是自身免疫炎症发病的关键因素
Nishada S Ramphal,Xinyuan Liu,Ilaria Palagi et al.
Nishada S Ramphal et al.
NIK (Map3k14) is a central regulator of noncanonical NF-κB signaling and immune homeostasis. Mutations in this kinase are linked to autoimmune disorders, including multiple sclerosis (MS). Both germline and T cell-specific deletion of NIK ...
Central neurons encode interleukin-1β signals and mediate stress-induced inflammation [0.03%]
中枢神经元编码白细胞介素-1β信号并介导应激诱导的炎症反应
Okito Hashimoto,Tyler D Hepler,Aisling Tynan et al.
Okito Hashimoto et al.
The brain encodes and stores information about peripheral inflammation and can directly recapitulate prior inflammatory responses. However, whether individual cytokines activate specific neural circuits to produce distinct physiological res...
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation [0.03%]
PI3Kδ-Foxo1-FasL信号放大环重新布线CD4+T细胞信号传导和分化
Dominic P Golec,Pedro H Gazzinelli-Guimaraes,Daniel Chauss et al.
Dominic P Golec et al.
While inputs regulating CD4+ T helper (Th) cell differentiation are well defined, the integration of downstream signaling with transcriptional and epigenetic programs that define Th lineage identity remains incompletely resolved. PI3K signa...
Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling [0.03%]
免疫检查点抑制剂诱导的心肌炎依赖于CD8 T细胞衍生的TNF和TNFR2信号转导
Kathrynne A Warrick,Anne Katrine Z Johansen,Mengchi Jiao et al.
Kathrynne A Warrick et al.
Immune checkpoint inhibitors (ICIs) improve cancer survival but can trigger immune-related adverse events. Among these, fulminant myocarditis is an often fatal complication with limited therapies. We developed a mouse model employing cardio...
Lawrence P Kane
Lawrence P Kane
In this issue of JEM, Golec et al. (https://doi.org/10.1084/jem.20252154) report that a mutation of PI-3 kinase underlying activated PI3K δ syndrome (APDS) impairs type 2 immunity. Surprisingly, mice with this mutation have disordered resp...
Hao Shi,Hongbo Chi
Hao Shi
Mapping the causal circuits that shape the phenotypic and functional landscape of immune cells remains a formidable challenge. Recent advances in pooled CRISPR-based screens, coupled with multiplexed single-cell profiling and imaging-based ...
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself [0.03%]
干扰素诱导的人类巨噬细胞记忆由细胞因子信号的持久性维系
Aleksandr Gorin,Siyue Niu,Noa Harriott et al.
Aleksandr Gorin et al.
Macrophages, as key sentinel cells of the innate immune system, can retain memory of prior stimulus exposure. IFNγ plays a central role in maintaining trained immunity in vivo and can induce potent memory in macrophages. Such memory is ass...
Luca Frosio,Renato Ostuni
Luca Frosio
Innate immune cells can retain molecular imprints of past encounters long after the initial stimulus has ceased. In this issue, Gorin et al. (https://doi.org/10.1084/jem.20250976) reveal an unexpected mechanism by which IFN-γ sustains trai...
Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2 [0.03%]
关于针对乳糜泻自身抗原组织型转谷氨酰胺酶2的B细胞耐受性和抗体产生的更正通知
M Fleur du Pré,Jana Blazevski,Alisa E Dewan et al.
M Fleur du Pré et al.
Correction: Contribution of IL-17-producing γδ T cells to the efficacy of anticancer chemotherapy [0.03%]
关于IL-17分泌的γδT细胞对抗癌化疗疗效贡献的更正通知
Yuting Ma,Laetitia Aymeric,Clara Locher et al.
Yuting Ma et al.