NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation
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NIK (Map3k14) is a central regulator of noncanonical NF-κB signaling and immune homeostasis. Mutations in this kinase are linked to autoimmune disorders, including multiple sclerosis (MS). Both germline and T cell-specific deletion of NIK had been demonstrate... ...
