Cullin 2 elevates Warburg effect to accelerate the development of hypoxic pulmonary hypertension [0.03%]
Cul2通过上调瓦博格效应促进缺氧性肺动脉高压的发展
Qiufen Xun,Qing Yang,Guofeng Zhu et al.
Qiufen Xun et al.
Pulmonary arterial hypertension (PAH) is a disease characterized by abnormally high pulmonary arterial blood pressures caused by a variety of heterogenous diseases and different pathogenetic mechanisms. This study establishes a hypoxic pulm...
Necroptosis Inhibition Preserves Diaphragm Function in Experimental Sepsis [0.03%]
抑制坏死性凋亡能保持内毒素诱导的脓毒症模型中小鼠膈肌功能
Xin Fu,Lie-Tao Wang,Qian Xu et al.
Xin Fu et al.
Diaphragm dysfunction in sepsis remains a critical challenge in intensive care, yet its underlying mechanisms are poorly understood. This study investigates the role of necroptosis, a recently recognized form of programmed cell death, in se...
KLF Transcription Factor 5/Lysophosphatidic Acid Receptor 5 Induced M2 Macrophage Activation and Inflammation by Modulating Phosphorylation of Mitogen-Activated Protein Kinase Kinase Kinase 7 in Pediatric Asthma [0.03%]
儿童哮喘中KLF转录因子5/溶血磷脂酸受体5通过调节丝裂原活化蛋白激酶活化酶7磷酸化诱导M2型巨噬细胞激活和炎症
Jing Li,Meixue Chen,Lingling Lu et al.
Jing Li et al.
Pediatric asthma is a respiratory disease in which M2 macrophages play a critical role. Here, the role and molecular mechanism of lysophosphatidic acid receptor 5 (LPAR5) were investigated in pediatric asthma through in vivo and in vitro ex...
A Seminal Work That Defined the Pathology of Frontotemporal Dementias and the Concept of TDP-43 Proteinopathies [0.03%]
定义额颞叶痴呆病理及TDP-43蛋白病概念的开山之作
Steven L Carroll
Steven L Carroll
The American Journal of Pathology and the American Society for Investigative Pathology: Forging the Next Century of Insights into Mechanisms of Disease [0.03%]
美国病理学家杂志和美国病理学调查协会：打造疾病机制下一个世纪的洞察力锻造下一世纪的疾病机制洞察力《美国病理学杂志》和《美国病理学协会》
Martha B Furie,Pilar Alcaide,William B Coleman et al.
Martha B Furie et al.
YAP AND TEAD ARE TRANSCRIPTIONAL REGULATORS OF NEUROENDOCRINE DIFFERENTIATION AND GROWTH IN CARCINOID CELLS [0.03%]
YAP 和TEAD是神经内分泌分化和类癌细胞增殖的转录调节因子
Jina Nanayakkara,Xiaojing Yang,Simona Damiani et al.
Jina Nanayakkara et al.
Molecular regulators of variably aggressive carcinoid tumors are unknown. Since carcinoids have low expression of Yes-associated protein (YAP), we hypothesized that low YAP expression provides a molecular advantage to carcinoids by preventi...
Selective Depletion of Gut Gram-Negative Bacteria Attenuates Alcohol-Binge-Induced Cardiovascular Dysfunction by Lowering Cardiac Anandamide Levels [0.03%]
选择性耗尽肠道革兰氏阴性细菌通过降低心脏中的阿南达amide水平来缓解酒精滥用心血管功能障碍
Sarah Cohen,Meagan Donovan,Davin Gardner et al.
Sarah Cohen et al.
Binge drinking contributes to a rising number of emergency room visits in the United States. Our previous work demonstrated that an alcohol binge impairs cardiac performance and exerts complex hemodynamic effects through the activation of t...
Silencing USP10 alleviates persistent corneal epithelial defect in mice [0.03%]
USP10基因沉默缓解小鼠持续性角膜上皮缺损
Arpan Banerjee,Mohammad Anjum Shaik,Christine Tilstra-Smith et al.
Arpan Banerjee et al.
Persistent corneal epithelial defect (PCED) is a condition in which the corneal epithelium fails to heal properly after injury resulting in vision loss. Previous studies demonstrate that the deubiquitinase, USP10 is a key regulator of wound...
Loss of aquaporin-1 in tumor cells fosters intrahepatic cholangiocarcinoma progression [0.03%]
肿瘤细胞中水通道蛋白-1的丢失促进肝内胆管癌进展
César Gaspari,Carine Beaupere,Seth Richard et al.
César Gaspari et al.
Aquaporin-1 (AQP1) is a water channel expressed by cholangiocytes described to modulate cell proliferation and invasion in several cancers. But the role of AQP1 in cholangiocarcinoma (CCA) remains unknown. Our aim was to study the function ...