ZBP1 Knockdown Attenuates Photoreceptor Cell Death After Retinal Detachment in Association with Reduced cGAS-STING Signaling and PANoptosis-Related Pathway Activation [0.03%]
ZBP1敲低通过降低cGAS-STING信号和PANoptosis相关通路激活来减轻视网膜脱离后的感光细胞死亡
Yuewei Peng,Feiyu Jin,Bochen Yao et al.
Yuewei Peng et al.
Retinal detachment (RD) is caused by the separation of the neural retina from the retinal pigment epithelium, which leads to photoreceptor cell death as the main cause of vision loss. Here, this study investigated the role of ZBP1-mediated ...
Bim inhibition ameliorates visual loss and promotes axon regeneration by upregulation of Drd1 expression [0.03%]
Bim抑制通过上调Drd1表达改善视力丧失并促进轴突再生
Zhenhao Cheng,Lingling Wu,Yilun Qu et al.
Zhenhao Cheng et al.
This study evaluated the neuroprotective effects of inhibiting the pro-apoptotic molecule Bim (Bcl-2-interacting mediator of cell death) in retinal ganglion cells (RGCs). A mouse optic nerve crush (ONC) model was used to induce RGC degenera...
An Explanatory Deep Learning Pipeline for the Prediction and Visualization of Spatially Resolved Biomarker Expression in Triple-Negative Breast Cancer [0.03%]
一种解释性深度学习流水线用于三阴性乳腺癌空间解析生物标志物表达的预测和可视化
Vibha R Rao,Madhumala K Sadanandappa,Candice C Black et al.
Vibha R Rao et al.
Histopathologic evaluation remains central to cancer diagnosis and treatment planning, yet the molecular programs underlying distinct tissue morphologies aren't routinely accessible in clinical workflows. Spatial transcriptomic/proteomic pl...
D-Dopachrome Tautomerase Facilitates UVB-Induced Skin Photoaging in Mice [0.03%]
D-多巴胺色酮互变异构酶促进小鼠皮肤光老化
Ko Kagoyama,Tsugunobu Andoh,Teruhiko Makino et al.
Ko Kagoyama et al.
D-dopachrome tautomerase (D-DT, or MIF-2) is a homolog of the macrophage migration inhibitory factor (MIF), which shares receptor usage and downstream signaling. Although MIF is known to mediate UV-induced inflammation and matrix remodeling...
Novel murine models of hematopoietic-endothelial crosstalk in JAK2V617F-associated cardiovascular disease [0.03%]
与JAK2V617F相关的血小板衍生生长因子受体β信号在血管疾病中的作用：新型小鼠模型研究造血内皮细胞相互作用
Haoyi Zheng,Huichun Zhan
Haoyi Zheng
Cardiovascular disease (CVD) is a major complication of JAK2V617F-positive myeloproliferative neoplasms (MPNs), yet the mechanisms linking mutant hematopoiesis to CVD remain incompletely understood. We developed three complementary murine m...
A4gnt-deficient mice show enhanced IL-11Rα-gp130-JAK2-STAT3 signaling in early stages of gastric tumorigenesis: Comparative analysis with A4gnt and Il11 doubly-deficient mice [0.03%]
A4GNT缺陷小鼠胃肿瘤发生早期IL-11Rα-GP130-JAK2-STAT3信号转导增强：与A4GNT和IL11双重缺陷小鼠的比较分析
Satoru Harumiya,Mark Joseph Maranan Desamero,Shusuke Mikoshiba et al.
Satoru Harumiya et al.
Gastric gland mucins contain O-glycans carrying terminal α1,4-linked N-acetylglucosamine (αGlcNAc). A previous study demonstrated that A4gnt-deficient mice lack αGlcNAc, spontaneously develop differentiated-type gastric adenocarcinoma, a...
Characterization and Therapeutic Application of Matrix-Bound Nanovesicles in Alcohol-Related Liver Disease [0.03%]
酒精相关性肝病的基质结合型纳米囊泡的治疗作用及机制研究
Yekaterina Krutsenko,Bashar Al Matour,Jiang Li et al.
Yekaterina Krutsenko et al.
Alcohol-related liver disease (ALD) is characterized by hepatocellular injury, oxidative stress, inflammation, and extracellular matrix remodeling, yet effective therapies remain limited. Matrix-bound nanovesicles (MBVs), bioactive vesicles...
Fusion Gene Detection Enhances Clinical Outcome Prediction of Hepatocellular Carcinoma Through Machine Learning Analyses [0.03%]
融合基因检测通过机器学习分析增强肝细胞癌临床结果预测
Yan-Ping Yu,Silvia Liu,Aatur Singhi et al.
Yan-Ping Yu et al.
Hepatocellular carcinoma is one of the most lethal malignancies for humans. Assessing the clinical outcomes of HCC remains challenging. In this study, a panel of 20 fusion genes in 200 hepatocellular carcinoma (HCC) samples was analyzed to ...
FAK activation mediates IQGAP3-promoted lung metastasis in osteosarcoma [0.03%]
FAK激活介导IQGAP3促进成骨肉瘤肺转移
Jingyu Cao,Ya Li,Lihua He et al.
Jingyu Cao et al.
Osteosarcoma (OS), the most common primary malignant bone tumor, is characterized by a high metastatic propensity and poor survival, highlighting the urgent need to define the molecular drivers of its progression. Here, bioinformatics and c...
Multimodal AI in Tissue Diagnostics: Vision-Language Models and the Future of Computational Pathology [0.03%]
组织诊断中的多模态人工智能：视觉-语言模型与计算病理学的未来
Rong Xia,Brian Isett,Jie Chen et al.
Rong Xia et al.
Vision-language models (VLMs) represent an emerging class of multimodal artificial intelligence (AI) systems that integrate visual information with natural-language understanding and generation. In computational pathology, VLMs provide a fr...