A4gnt-deficient mice show enhanced IL-11Rα-gp130-JAK2-STAT3 signaling in early stages of gastric tumorigenesis: Comparative analysis with A4gnt and Il11 doubly-deficient mice
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Gastric gland mucins contain O-glycans carrying terminal α1,4-linked N-acetylglucosamine (αGlcNAc). A previous study demonstrated that A4gnt-deficient mice lack αGlcNAc, spontaneously develop differentiated-type gastric adenocarcinoma, and exhibit significa... ...
