Jinyu Chang,Qi Sun,Ning Ding et al.
Jinyu Chang et al.
In this study, we present a "flexible methylene bridge" strategy for designing tetrazole-based energetic materials. This approach enables structural modulation through two pathways: (1) solvent-induced bridge distortion to access different ...
Glycosyl Radical-Based C-H Glycosylation of Coumarins Enabled by Photocatalysis [0.03%]
光催化促进的葡萄糖基自由基与香豆素类衍生物的C-H糖基化反应
Qiang Pan,Min Wang,Yuan-Hong Tu et al.
Qiang Pan et al.
We report the photocatalytic C-H glycosylation of coumarins with glycosyl radicals. This transformation employs an organic photosensitizer and proceeds under mild conditions in the presence of a weak acid. The reaction exhibits α-selectivi...
Synthesis of Carbazole-Based Electron Donor-Acceptor Architectures Enabling Ultrasensitive Epinephrine Detection [0.03%]
基于咔唑的电子给体-受体结构的合成及其超高灵敏度检测肾上腺素性能的研究
Ningwen Sun,Jinjin Ding,Hongxing Jia et al.
Ningwen Sun et al.
In this work, using carbazole as the electron donor and pyridinyl as the acceptor, we synthesized three novel donor-acceptor (D-A) architectures (CzPs). Notably, all exhibited significant solvent-dependent fluorescence emission in the visib...
Stereoselective Synthesis of Diaza-Hexatrienes via [1,6]- O-to- N Group Transfer Strategy [0.03%]
基于[1,6]位氧到氮导向基转移的diaza-己三烯类化合物的立体选择性合成
Srashti Bhardwaj,Sandeep Kumar,Janakiram Vaitla
Srashti Bhardwaj
Herein, we report a transition metal-free synthesis of Z-configured 2,3-diaza-1,3,5-hexatrienes via a base-mediated rearrangement of O-substituted salicylaldehyde N-tosylhydrazones. This unprecedented O-to-N group transfer occurs under mild...
NHC-Catalyzed Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes [0.03%]
由肟酸酯和醛合成3,5-取代的1,2,4-噁二唑的新方法
Haibin Zhu,Zhenqian Fu
Haibin Zhu
1,2,4-Oxadiazoles are key scaffolds in natural products and bioactive molecules. This study reports an efficient NHC-catalyzed [4 + 1] cyclization from accessible aldehydes and amidoximes to build it, concisely synthesizing tioxazafen, atal...
1,8-Di(2-ethynylaryl)biphenylenes: Palladium-Catalyzed Intramolecular Cycloisomerization and Subsequent Thermal Rearrangement [0.03%]
1,8-二（2-炔丙基）联苯：钯催化分子内环异构化和随后的热重排反应
Hsiang-Han Chen,Chih-Hsuan Liu,Wei-Ting Ou et al.
Hsiang-Han Chen et al.
A cascade reaction for 1,8-dibromobiphenylene A with arylboronic acid B toward an unusual product C was comprehensively investigated. The initially formed Suzuki product D underwent an unprecedented palladium-catalyzed cycloisomerization, y...
Photoinduced Deoxygenative Boration of Unactivated Alcohols Involving In-Situ-Formed Alkyl Iodides [0.03%]
原位生成烷基碘化物参与的未活化醇光促进去氧硼化反应
Xiaojie Liu,Biping Xu,Martin Oestreich
Xiaojie Liu
A method for the direct two-step/one-pot conversion of unactivated 1°, 2°, and 3° alcohols into the corresponding alkylboronate esters is reported. The hydroxy group is activated in situ by reaction with the Hendrickson "POP" reagent. Th...
Tetrazole Placeholder-Directed Strategy: Precise Synthesis of Tri(tetrazolyl)-Functionalized Pyrazole [0.03%]
四氮唑占位基导向策略：三(四氮唑)功能化吡唑的精准合成
Jing Liu,Miao Li,Mingjie Tang et al.
Jing Liu et al.
We report a concise synthesis of the fully tetrazole-substituted pyrazole 3,4,5-tris(1H-tetrazol-5-yl)-1H-pyrazole (TYX-39). The key intermediate, 3,5-dicarbonitrile-4-(1H-tetrazol-5-yl)-1H-pyrazole (2), was prepared by a piperidine-catalyz...
Hydrophilic BIPHEPHOS Ligand for Pd-Mediated Cysteine Allylation of Peptides and Proteins in Water [0.03%]
用于水溶液中半胱氨酸肽和蛋白质的钯介导亚烷基化反应的亲水性BIPHEPHOS配体
Thomas Schlatzer,Julia Kriegesmann,Mark Bieber et al.
Thomas Schlatzer et al.
The selective and natural post-translational modification of peptides and proteins under biocompatible conditions remains a challenge. Herein, we report a hydrophilic variant of the BIPHEPHOS ligand featuring diethyl phosphonates as solubil...
Intramolecular Dearomative [2 + 2] Cycloaddition of (Hetero)arenes via Energy Transfer Catalysis: Exploration of Divergent Three-Dimensional Skeleton Editing [0.03%]
通过能量转移催化作用实现的（杂）芳烃分子内去芳香化[2+2]环加成反应：三维骨架编辑发散合成研究
Kaiao Xu,Xueying Wang,Yaqian Liu et al.
Kaiao Xu et al.
Dearomative [2 + 2] cycloadditions offer a powerful route for converting planar arenes into complex three-dimensional (3D) scaffolds prevalent in bioactive molecules. Herein, we report an intramolecular dearomative [2 + 2] cycloaddition of ...