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Hydrophilic BIPHEPHOS Ligand for Pd-Mediated Cysteine Allylation of Peptides and Proteins in Water

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The selective and natural post-translational modification of peptides and proteins under biocompatible conditions remains a challenge. Herein, we report a hydrophilic variant of the BIPHEPHOS ligand featuring diethyl phosphonates as solubilizing groups, which ... ...