NHC-Catalyzed Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes
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1,2,4-Oxadiazoles are key scaffolds in natural products and bioactive molecules. This study reports an efficient NHC-catalyzed [4 + 1] cyclization from accessible aldehydes and amidoximes to build it, concisely synthesizing tioxazafen, ataluren, and an mGluR5 ... ...
