Copper-Catalyzed Divergent C-S Bond Cleavage of Vinylsulfonium Salts: Controllable Phosphoryloxylation and Phosphinoylation [0.03%]
铜催化烯基锍盐的多样性C-S键活化：可控磷酰氧化物和次膦酰氧化物合成反应
Meng Li,Longzhi Zhu,Weifeng Xu et al.
Meng Li et al.
A facile copper-catalyzed system enables controllable phosphoryloxylation and phosphinoylation of vinylsulfonium salts with P(O)-H compounds. Reaction divergence is achieved by employing distinct copper catalysts to steer the selective clea...
Chemoselective Atmospheric Hydrogenation of Two C═C bonds of α,β-Unsaturated Diketones Derived from Biobased 5-Hydroxymethylfurfural Catalyzed by a Metal-Ligand Bifunctional Iridium Catalyst [0.03%]
由生物基5-羟甲基糠醛衍生的α, β-不饱和二酮的化学选择性大气氢化反应研究
Beixuan Dong,Yiqian He,Yuexin Ji et al.
Beixuan Dong et al.
Chemoselective atmospheric hydrogenation of two C═C bonds of α,β-unsaturated diketones derived from 5-hydroxymethylfurfural (5-HMF) has been accomplished. In the presence of [Cp*Ir(2,2'-bpyO)(OH2)] (0.5 mol %), a series of desired produc...
Rhodium-Catalyzed Asymmetric Remote C(sp3)-H Borylation of Aldehyde-Derived Silyl Enol Ethers [0.03%]
醛衍生物硅烯醇醚的远程C-H硼化反应及其立体选择性研究
Yisen Yao,Jie Li,Jintao Sun et al.
Yisen Yao et al.
The asymmetric remote C(sp3)-H borylation of alkenes has become an effective means of remote functionalization. However, the application of silyl enol ethers in this transformation remains underexplored. Herein, we report a Rh-catalyzed asy...
Synthesis of Si-Bridgehead Polycyclic Aromatic Hydrocarbons via Ru-Catalyzed Double Annulation of Secondary Silanes with Internal Alkynes [0.03%]
钌催化二级硅烷与内部炔烃的双环化反应合成Si-桥连多环芳香烃化合物
Yuta Suenaga,Mitsuhiro Deguchi,Shin-Ichi Yamamoto et al.
Yuta Suenaga et al.
The incorporation of silicon into the bridgehead positions of polycyclic aromatic hydrocarbons is challenging because it requires successive annulations and formation of multiple Si-C bonds. This study presents a Si-H directed double annula...
Haruka Ochiishi,Kengo Todaka,Yuri Tabuchi et al.
Haruka Ochiishi et al.
We have developed a catalytic β-C-H amination of amino acid derivatives using amino acid Schiff bases, which are traditionally employed only in α-functionalization reactions. The present transformation expands the synthetic utility of the...
Diastereoselective Cascade Annulation of Distal Formyl Enones and Sulfur Ylides toward Cyclopropane-Fused Cycloalkanes [0.03%]
远程形式基烯酮和硫叶立德的对映选择性串联环化反应构建并环 fused cycloalkane 并环化合物
Swati Lekha Mondal,Koushik Patra,Mahiuddin Baidya
Swati Lekha Mondal
A metal-free cascade annulation that harnesses the ambiphilic reactivity of distal formyl enones and sulfur ylides is developed to access high-value cyclopropane-fused cycloalkanes. Using readily accessible 6-formyl enones, the method deliv...
Microwave-Assisted Precise Synthesis of Alkyl/Aryl-Modified Triazolyl-Phenylalanine Hybrids and Peptide Modifications through Multicomponent Reaction [0.03%]
通过多组分反应合成烷基/芳基修饰的三氮唑酪氨酸衍生物及其肽类化合物
Karuna Thakare,Aman Singh Barahdia,Rahul Jain
Karuna Thakare
We report a regioselective synthesis of triazolyl-phenylalanine hybrids via a two-step process: alkynylation at ambient conditions followed by multicomponent reaction, which includes protodesilylation, azidation, and [3 + 2] cycloaddition u...
SN2 Glycosylation Enabled by a Directing-Group-on-Leaving-Group Strategy: Highly Stereoselective Synthesis of Glycosyl Carboxylates [0.03%]
导向基团连接在离去基团上的SN2型糖苷化反应：甘露糖基碳水化合物立体选择性合成新策略
Qing Zhang,Yongliang Zhang,Liming Zhang
Qing Zhang
By employing a directing-group-on-leaving-group (DGLG) strategy, we have implemented an SN2 glycosylation of carboxylic acids with mostly complete stereochemical inversion at the anomeric position and largely near quantitative yields. This ...
Electrophotochemical Ce-Catalyzed Radical Truce-Smiles Rearrangement of Cycloalkanols [0.03%]
环烷醇的电光化学Ce催化自由基Traux重排反应
Muhammad Adnan Bashir,Yong Jiang,Cai Zhai et al.
Muhammad Adnan Bashir et al.
The Truce-Smiles rearrangement enables access to arylethylamines in pharmaceuticals, yet typically requires amide substrates or prefunctionalized radical precursors. We report a redox-neutral electrophotochemical rearrangement of cycloalkan...
Copper-Catalyzed Radical-Triggered Annulation-Halocyanomethylation Reaction of Alkynyl-Bearing Bicyclo[1.1.0]butanes (BCBs) Leading to Spirocyclobutyl Quinolinones [0.03%]
铜催化下含端炔基 bicyclo[1.1.0]丁烷（BCB）的自由基偶联-卤代氰甲基化反应生成螺环丁基喹唑酮类化合物
Xiao Zou,Zheng-Ren Jia,Yu-Ting Wang et al.
Xiao Zou et al.
The novel copper-catalyzed radical-triggered annulation-halocyanomethylation reaction, involving preprepared alkynyl-substituted bicyclo[1.1.0]butanes (BCBs) and haloacetonitrile, was reported for the first time, enabling the synthesis of v...