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Copper-Catalyzed Radical-Triggered Annulation-Halocyanomethylation Reaction of Alkynyl-Bearing Bicyclo[1.1.0]butanes (BCBs) Leading to Spirocyclobutyl Quinolinones

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The novel copper-catalyzed radical-triggered annulation-halocyanomethylation reaction, involving preprepared alkynyl-substituted bicyclo[1.1.0]butanes (BCBs) and haloacetonitrile, was reported for the first time, enabling the synthesis of various halocyanometh... ...