SN2 Glycosylation Enabled by a Directing-Group-on-Leaving-Group Strategy: Highly Stereoselective Synthesis of Glycosyl Carboxylates
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By employing a directing-group-on-leaving-group (DGLG) strategy, we have implemented an SN2 glycosylation of carboxylic acids with mostly complete stereochemical inversion at the anomeric position and largely near quantitative yields. This chemistry is based o... ...