Minjoon Shin,Seung Mo Seo,Sunkyu Han
Minjoon Shin
Norsecurinamine B represents the first example of an NH-bridged dimeric Securinega alkaloid, in which two norsecurinine monomers are joined through an amine linker at their endo faces. However, the exo face of norsecurinine is intrinsically...
Gene Cluster Directs Diversified Carbazole Biosynthesis via Cooperative Halogenation, Hydroxylation, and Methylation [0.03%]
基因簇通过协同卤化、羟基化和甲基化作用指导多样的咔唑生物合成
Qiaoling Wu,Feng Li,Ming Peng et al.
Qiaoling Wu et al.
Chlocarbazomycins are bioactive carbazoles with therapeutic potential. Here, we report a conserved gene cluster (ccz) that directs its biosynthesis via a novel pathway. This cluster encodes a versatile tailoring system, including a regiosel...
Photocatalytic Decarboxylative Hydroalkylation of Alkynes and Alkenes [0.03%]
光催化下醛亚胺促进的炔烃和烯烃的脱羧氢烷基化反应
Pengjie Yao,Taixian Lin,Jie Li et al.
Pengjie Yao et al.
A photocatalyzed radical decarboxylative hydroalkylation of alkynes and alkenes has been developed for the efficient synthesis of allylamine and arylpropylamine derivatives. This protocol employs organic 4CzIPN as a photocatalyst and avoids...
Privileged Scaffold Hybridization for Rigid Tetracyclic Energetics: Uniting Performance, Stability, and Safety [0.03%]
刚性四环体系的力学与电学协同：兼具高性能、高安全及长寿命的新原理储能装置
Sagar Nehe,Vikas D Ghule,Srinivas Dharavath
Sagar Nehe
This study underlines the strategic use of privileged scaffold hybridization in designing and synthesizing a unique new class of polynitro energetic compounds. These compounds exhibit high densities (1.77-1.87 g cm-3), high positive heats o...
Co-MHAT-Catalyzed Wacker-Type Oxidation of 1,3-Enynes into Ynones [0.03%]
双功能Co-MHAT催化1,3-亚炔烃的Wacker型氧化反应合成烯酮化合物
Ying Jiang,Wen-Chao Zhao,Kai Xiao et al.
Ying Jiang et al.
The transformation of 1,3-enynes is one of the important methods for obtaining a variety of valuable organic molecules. In the past few decades, significant progress has been made in the difunctionalization of 1,3-enynes via a radical proce...
Copper-Catalyzed Diazo Controlled Annulation of Naphthylamines to Benzo[ g]indoles [0.03%]
铜催化萘胺与茋𬭩盐的偶氮控环化反应合成苯并吉德醇类化合物
Rohit Singh,Pradeep Yadav,Vivek Singh Baghel et al.
Rohit Singh et al.
Herein, we report a diazo-controlled Cu(II)-catalyzed annulation of naphthylamines that provides divergent access to benzo[g]indole frameworks with excellent selectivity. Different diazocarbonyl compounds govern the reaction pathway, and ma...
Geometry-Controlled Synthesis of Pyrido/Pyrrolo-isoindolones via MHAT Radical Cyclization of Carbethoxy Methylene Isoindolone [0.03%]
几何控制的MHAT自由基环化合成吡啶/吡咯并异吲哚酮类化合物
Santosh J Gharpure,Rupali S Chavan,Kaushik C Pansuriya et al.
Santosh J Gharpure et al.
A geometry-dependent intramolecular MHAT (metal-hydride hydrogen atom transfer) cyclization of olefins using carbethoxy methylene isoindolone as a radical acceptor has been developed for the synthesis of pyrroloisoindolone and pyridoisoindo...
Discovery and Biosynthesis of Dehydroalanine-Containing Lasso Peptide by a Hybrid Biosynthetic System [0.03%]
杂合生物合成系统中去氢丙氨酸修饰环肽的发现及结构解析
Yu-Xia Ma,Jin-Ming Di,Jin-Long Lu et al.
Yu-Xia Ma et al.
Lasso peptides and lanthipeptides are two major classes of ribosomally synthesized and post-translationally modified peptides (RiPPs), each defined by distinct post-translational modification (PTM) enzymes. We identify a hybrid biosynthetic...
Dual N-Heterocyclic Carbene/Thiourea Catalysis Enabled Asymmetric Dearomative Michael Addition of C3-Fluorooxindoles to 2-Nitrobenzofurans [0.03%]
双重N-杂环卡宾/硫脲催化的C3氟氧吲哚与2-硝基苯并呋喃不对称去芳构化迈克加成反应
Aniruddh Pratap,Akash Pradhan,Arpita Tiwari et al.
Aniruddh Pratap et al.
We report a synergistic dual-catalytic approach that combines a commercially available chiral N-heterocyclic carbene (NHC) with a simple achiral thiourea catalyst to achieve a dearomative Michael addition. This cooperative system enables no...
A Modular Approach to Access 1,4-Benzoxazinones, Spirooxazolidinones, and 4,1-Benzoxazepinones via Oxidative Aryl C-N Bond Formation Using Catalytic Hypervalent Iodine [0.03%]
通过催化型高碘𬭩盐氧化偶联芳基C-N键构筑苯并噁嗪酮、螺噁唑啶和苯并恶唑烷杂环骨架化合物的新策略
Deeksha,Ritesh Singh
Deeksha
Herein, we present a highly efficient (one-pot) and unprecedented method for synthesizing 1,4-Benzoxazinones and 4,1-Benzoxazepinones under transition metal-free conditions through direct aryl C-H amination. For the first time, this work ha...