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Geometry-Controlled Synthesis of Pyrido/Pyrrolo-isoindolones via MHAT Radical Cyclization of Carbethoxy Methylene Isoindolone

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A geometry-dependent intramolecular MHAT (metal-hydride hydrogen atom transfer) cyclization of olefins using carbethoxy methylene isoindolone as a radical acceptor has been developed for the synthesis of pyrroloisoindolone and pyridoisoindolone derivatives. Th... ...