Photoredox-Catalyzed Defluorinative [4 + 2] Cycloaddition of α-Fluoro-β-keto Esters and Alkynes by Single Photosensitizer [0.03%]
单光敏剂介导的α-氟-β-酮酸酯与炔烃的光氧化还原脱氟[4+2]环加成反应
Rui-Xue Liu,Xiu-Long Yang,Hao-Yuan Li et al.
Rui-Xue Liu et al.
A protocol for C-F bond activation using a single organic photocatalyst was developed. The mechanism involves the self-sorting of α-fluorinated-β-keto esters to generate two radicals: one is highly electrophilic and undergoes rapid benzan...
(CF3S)2C═S: Electrophilic Site at the Thiocarbonyl Sulfur for the Incorporation of Multiple CF3S Groups [0.03%]
（CF₃S）₂C＝S：供引入多个CF₃S基的硫羰硫的亲电位点
Meng-Qi Sun,Jun Sun,Jin-Hong Lin et al.
Meng-Qi Sun et al.
Although the thiocarbonyl group is typically attacked at sulfur due to orbital control, strong σ-electron-withdrawing groups can invert this reactivity, rendering the carbon electrophilic. Herein, we demonstrate that (CF3S)2C═S, despite b...
Copper-Mediated Dehydroamination of Primary Amines for Olefination [0.03%]
一級胺的去氫氨化偶聯 olefination 反應
Ke-Han He,Yan Mei,Xin Tian et al.
Ke-Han He et al.
Herein, we introduce a versatile and effective copper-mediated approach for the dehydroamination of a wide range of primary amines encompassing complex bioactive compounds. This method facilitates the transformation of primary amines into o...
P450 Cyptide Synthase KwwB Catalyzes Trp-C5-Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides [0.03%]
P450酶KwwB催化色氨酸C5到色氨酸N1的交联并接受各种前体肽底物
Jabal Rahmat Haedar,Gaja Swarna Kumari,Vic Kiselov et al.
Jabal Rahmat Haedar et al.
Cytochrome P450 enzymes install C-C, C-N, or C-O cross-links on the precursor peptides of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, we bioinformatically mapped P450 enzymes based on the known families...
Highly Regioselective and Stereoselective Haloazidation of Alkynes Mediated by a Halide-Bridged Charge-Transfer Complex [0.03%]
由卤素桥连电荷转移复合物介导的高区域和立体选择性炔烃卤氨基化反应
Chaofan Hu,Chen-Xi Xia,Fang Ma et al.
Chaofan Hu et al.
More than 100 years after the initial report of alkene halogenation-azidation reactions, a general method for haloazidation of alkynes has remained elusive, primarily due to the higher bond dissociation energy of alkynes and inherent stereo...
Visible-Light-Induced Acylsilylation of Nitrosoarenes for Synthesis of N-Arylhydroxamic Acid Silicon Esters [0.03%]
硝基苯并恶嗪衍生物的光诱导酰硅烷化反应合成N-芳基羟胺酸硅酯类化合物
Yin-Xia Wang,Chuang Wang,Na Li et al.
Yin-Xia Wang et al.
A visible-light-induced acylsilylation of nitrosoarenes with acylsilanes has been developed under transition-metal-free conditions. This reaction proceeds via a photoinduced [1,2]-Brook rearrangement of acylsilanes to generate nucleophilic ...
Photoinduced Palladium-Catalyzed Controllable Multicomponent Mono- or Di-C-glycosylation for the Construction of Alkyl C-Glycoconjugates [0.03%]
光诱导的钯催化可控多组分单或多C-糖基化构造烷基C-糖缀合物
Xin Zhuang,Xianyu Chen,Wenming Zhang et al.
Xin Zhuang et al.
A general modular assembly strategy for the selective synthesis of alkyl C-glycoconjugates was reported via a photoinduced Pd-catalyzed multicomponent mono- or di-C-glycosylation from a variety of glycosyl radical precursors, feedstock 1,3-...
Photoinduced Deoxygenation Reduction of Sulfoxides with HCl or HBr and Hydrocarbons [0.03%]
光诱导的硫氧化物与HCl或HBr和烃类化合物的脱氧还原反应
Feng Xu,Zemin Wang,Dayong Shi
Feng Xu
The deoxygenative reduction of sulfoxides to thioethers represents one of the most important transformations in organic synthesis, garnering significant attention in both academic research and industrial applications. Herein, we report a ph...
Hydrosilafluorenes as Recyclable Coupling Reagents for Direct Amidation of Carboxylic Acids with Amines [0.03%]
用于胺和羧酸直接酯交换反应的可回收氢硅氟烷基试剂
Fawwaz Azam,Brigida V Fernandes,Clive A Boateng et al.
Fawwaz Azam et al.
We have discovered both 9-methyl- and 9-phenyl-9H-9-silafluorene as effective reagents for direct amidation. The protocol is performed under open-air conditions without rigorous exclusion of moisture, producing amides in high yields with on...
Synthesis of Carborane-Fused Lactones via Electrochemical C(sp3)-H Lactonization: Access to Benzofused Lactone Bioisosteres [0.03%]
电化学C(sp³)-H环氧化物合成联硼烷并内酯及苯并稠合内酯生物电子等排体的新方法
Jee Eun Hong,Hee Chan Noh,Kyungsup Lee et al.
Jee Eun Hong et al.
The replacement of the benzene ring with its bioisosteres is a powerful strategy in drug discovery, yet the development of ortho-disubstituted benzene bioisosteres, particularly fused-ring systems, remains underexplored. Herein, we report a...