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Synthesis of Carborane-Fused Lactones via Electrochemical C(sp3)-H Lactonization: Access to Benzofused Lactone Bioisosteres

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The replacement of the benzene ring with its bioisosteres is a powerful strategy in drug discovery, yet the development of ortho-disubstituted benzene bioisosteres, particularly fused-ring systems, remains underexplored. Herein, we report an electrooxidative p... ...