Regioselective 1,2-Hydrogen Atom Transfer of N-Centered Radicals for C(sp3)-C(sp3) Coupling to Generate 1,2-Diamine Derivatives [0.03%]
N中心自由基区域选择性氢原子转移实现三级碳-三级碳偶联合成1,2-二胺类化合物
Yu Pan,Haitao Yang,Yifeng Bai et al.
Yu Pan et al.
Herein, 2-azaallyl anions are reported as super electron donors (SEDs) in the reduction of N-chlorodialkylamines to generate N-centered radicals (NCRs). The NCRs undergo regioselective net 1,2-hydrogen atom transfer (1,2-HAT) to yield C-cen...
Controlled Helical Distortion of Double Thia[7]helicenes via Inner-Rim Alkyl Substitution [0.03%]
内位烷基取代调控双硫杂[7]螺旋烯的螺线管状扭曲构象
Dehe Wang,Jingyun Tan,Long Zhou et al.
Dehe Wang et al.
Precise control of helical distortion in double helicenes is challenging due to their high intrinsic strain. Herein, we report modulation of helical distortion in a double thia[7]helicene through inner-rim alkyl substitution. Structural and...
Total Synthesis of the Oligostilbenes Anigopreissin A and Fuliginosin A [0.03%]
寡茋类天然产物Anigopreissin A和Fuliginosin A的全合成研究
Aldahir Ramos Orea,Valeri Martínez-Barrita,Arturo Mejía-Galindo et al.
Aldahir Ramos Orea et al.
A convergent synthesis of the natural stilbenes anigopreissin A and fuliginosin A is presented. The key step involves a copper-catalyzed heteroannulation between an oxime acetate and a 4-substituted 1,3-cyclohexanedione, yielding a suitably...
Pd(II)-Catalyzed [3 + 1 + 1 + 1] Cascade Annulation of N-Substituted Anilines with CO and Amines: Direct Access to N 1, N 3-Disubstituted Quinazoline-2,4(1 H,3 H)-diones [0.03%]
钯催化N取代苯胺与CO和胺的[3+1+1+1]环化反应：直接合成N1,N3双取代喹唑啉-2,4(1H,3H)-二酮类化合物
Xiaopeng Zhang,Jingyi Yang,Zhenhua Guo et al.
Xiaopeng Zhang et al.
In this study, we present an efficient and direct strategy for the synthesis of N1,N3-disubstituted quinazoline-2,4(1H,3H)-diones with high atom and step economy. The protocol involves a Pd(II)-catalyzed [3 + 1 + 1 + 1] cascade carbonylatio...
Xinru Zhang,Cunzhi Chen,Jiaxi Xu et al.
Xinru Zhang et al.
We achieve the Rh/(R,R)-Me-ferrocelane-catalyzed skeletal transformation of 1,2,3-thiadiazoles with cyclopent-2-en-1-ones and regio- and diastereospecifically construct highly enantiopure cyclopentanone-fused dihydrothiophenes that are othe...
Construction of Cyclopenta[ b]pyridine Frameworks via Pd(0) π-Lewis Base-Initiated Cascade Reaction of Enyne-Tethered Malononitriles [0.03%]
通过Pd(0) π-路易斯碱引发的烯炔连接丙二腈串联反应构建并五苯基吡啶框架结构
Shi-Cun Li,Shu-Qian Wang,Ming-Si Feng et al.
Shi-Cun Li et al.
A Pd(0) π-Lewis base-initiated cascade transformation of 1,3-enyne-tethered malononitriles is disclosed, proceeding through intramolecular vinylogous addition of the nucleophilicity-enhanced alkyne moiety to a pendent cyano group, cis/tran...
Enantioselective Synthesis of Triarylmethanes via Palladium-Catalyzed Desymmetric Carbonylation of Cyclic Diaryliodonium Salts [0.03%]
手性三芳基甲烷的对映选择性合成：钯催化环状二芳基碘
Xing Chen,Zihao Wang,Zhaoyu Sun et al.
Xing Chen et al.
A highly enantioselective desymmetric strategy was developed for the synthesis of enantioenriched triarylmethanes via palladium-catalyzed carbonylation reactions of six-membered cyclic diaryliodonium salts with CO gas and alcohols/amines. T...
Biomimetic Skeleton Conversion from Tiglianes into Three Euphorbia Diterpenoid Skeletons via Regioselective Cyclopropane Ring-Opening [0.03%]
苔利亚内酯类生物碱向三种大戟二萜的骨架转换研究：区域选择性环丙烷开环反应
Ming-Ju Wen,Wei-Ye Wu,Shu-Qi Wu et al.
Ming-Ju Wen et al.
Structurally complex Euphorbia diterpenoids represent a synthetic challenge. Here, we report a divergent strategy that biomimetically converts abundant tiglianes into three Euphorbia skeletons via regioselective cyclopropane ring-opening. T...
Pd-Catalyzed Three-Component Coupling of Aryl Bromides, Alkynes, and Anthranils To Access ortho Carbonyl N-Aryl Indoles [0.03%]
钯催化芳基溴、炔烃和邻氨基苯甲酰胺的三组分偶联反应合成2-芳氧基羰基-3-芳基吲哚类化合物
Wanting Chen,Yanping Huo,Qian Chen et al.
Wanting Chen et al.
A palladium-catalyzed three-component coupling of aryl bromides, alkynes, and anthranils has been developed for the direct and efficient synthesis of ortho carbonyl-substituted N-aryl indoles featuring a C-N chiral axis. Anthranil serves as...
Markovnikov-Selective Hydroboration of Unactivated Alkenes via MHAT under Cobalt/Photoredox Dual Catalysis [0.03%]
钴和光红氧化学催化协同促进未活化烯烃的MHAT反应及马尔可夫尼科夫选择性氢硼化反应
Yusuke Seino,Shintaro Dozen,Tatsuhiko Yoshino et al.
Yusuke Seino et al.
Catalytic Markovnikov-selective hydroboration of unactivated alkenes is a powerful tool for accessing alkyl boronic esters. Here, we report Markovnikov-selective MHAT hydroboration of unactivated alkenes enabled by cobalt/photoredox dual ca...