Pd(II)-Catalyzed [3 + 1 + 1 + 1] Cascade Annulation of N-Substituted Anilines with CO and Amines: Direct Access to N 1, N 3-Disubstituted Quinazoline-2,4(1 H,3 H)-diones
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In this study, we present an efficient and direct strategy for the synthesis of N1,N3-disubstituted quinazoline-2,4(1H,3H)-diones with high atom and step economy. The protocol involves a Pd(II)-catalyzed [3 + 1 + 1 + 1] cascade carbonylation/amidation/cyclocar... ...
