Synthesis of Polycyclic Indolines via Spiroindolenines: Mechanistic Validation and HDAC6 Inhibition Potential [0.03%]
通过斯派咯吲哚宁合成多环indholine:机理验证与HDAC6抑制潜能研究
Bo-Bo Gou,Chao-Feng Chong,Zhi-Yong Lu et al.
Bo-Bo Gou et al.
A highly selective and acid-controlled method for the synthesis of functionalized pentacyclic indolines from tryptophols and o-aminobenzaldehydes is described. Preliminary mechanistic studies provide direct evidence of the involvement of a ...
Construction of Chiral β-Boryl Aldehydes via Asymmetric Hydroformylation of 1,1-Disubstituted Alkenyl Boronates [0.03%]
不对称氢甲酰化合成手性β-硼基醛
Jiang Zhu,Cai You,Xiuxiu Li et al.
Jiang Zhu et al.
We report a Rh-catalyzed asymmetric hydroformylation of 1,1-disubstituted alkenyl boronic esters that provides direct access to a previously inaccessible class of dual-functional linchpin synthons bearing both an aldehyde and a boronic este...
Copper-Catalyzed Synthesis of Medium-Sized Cyclic Aminals via Annulation of Ketenimines and N-Acyliminium Ions [0.03%]
酮亚胺与N-酰亚氨基离子环化偶联构建中环氮杂环的铜催化研究
Chinmayee Choudhury,Subhamoy Biswas,Bikoshita Porashar et al.
Chinmayee Choudhury et al.
A CuBr-catalyzed intermolecular cascade strategy was developed to access medium-sized polycyclic aminals. While conventional cyclization encounters severe limitations due to inherent enthalpic and entropic constraints, this approach overcom...
Cobalt-Catalyzed Intramolecular Dearomative Alkylation of Phenols with Alkenes [0.03%]
钴催化酚的烯烃亲电加成 dearomative alkylation反应
Gao-Yang Yu,Yang-Ge Wang,Dan-Dan Yu et al.
Gao-Yang Yu et al.
A cobalt-catalyzed intramolecular dearomative ipso-spirocyclization of phenols bearing a tethered alkene has been developed. A range of structurally unique spirocyclodienone lactams were achieved in moderate to excellent yields. Synthetic t...
Triarylborane-Modified Aza[7]helicenes Featuring Two-Photon Absorption and Dual-State Circularly Polarized Luminescence [0.03%]
三芳基硼修饰的aza[7]螺旋烯：具有双光子吸收和双重圆偏振发光性质
Run-Ze Wang,Zhi-Qiang Liu,Min Wang et al.
Run-Ze Wang et al.
We here disclose two borylphenyl-substituted aza[7]helicenes, in which two 2,6-bis(trifluoromethyl)phenyl groups were introduced on boron to enhance the charge transfer feature. Both molecules display circularly polarized luminescence (CPL)...
Photoinduced P-Se Bond Cleavage of Diselenophosphinic Esters: En Route to Selenoethers and Phosphine Selenides [0.03%]
离解光诱导的P-Se键的离解二硒代磷烷酯：用于制备硒醚和磷化硒的方法及其结果
Yuzhuo Wang,Jun Dong,Jiahao Li et al.
Yuzhuo Wang et al.
Diselenophosphinic esters are conventionally employed as RAFT agents in polymerization. Herein, we report the novel photoactivity of diselenophosphinic esters, which can be readily generated in situ from potassium diphenylphosphinodiselenoa...
Disruption of p-π Conjugation Enables Halonium-Mediated Dearomative Difunctionalization of Benzothiophenes [0.03%]
共轭效应破坏实现苯并噻吩的亲电试剂介导去芳构化双官能团化反应
Xian-Yan Shen,Jing-Yu Yan,Ji-Rong Huang
Xian-Yan Shen
p-π conjugation enriches electron density and facilitates the reactivity of adjacent π systems while simultaneously constraining electron mobility in subsequent transformations. Building on prior sulfur oxide chemistry, we leverage disrup...
Vinylsilanes as Ethylene Surrogates: Rh(I)-Catalyzed Direct Hydroarylation of In Situ Generated Ethylene [0.03%]
乙烯的替代物：原位生成乙烯直接活化 aryllithium 类型反应底物铑(i)催化剂的作用
Rahul Bangari,Aritra Mukherjee,Supriya Rej
Rahul Bangari
A modular and practical approach to the Rh(I)-catalyzed hydroarylation of ethylene with arenes bearing a quinoline amide group has been developed. To address the inherent challenges of ethylene hydroarylation, particularly the reliance on h...
Selective Deprotonated Amide Activation of Dehydroalanine for Peptide Modification [0.03%]
脱氢丙氨酸的选择性脱质子胺激活肽修饰反应
Pengxin Wang,Jinyuan Gong,Yuntao Shi et al.
Pengxin Wang et al.
Herein, we have discovered a unique deprotonated amide activation of dehydroalanine and developed a remote functionalization reaction of the double bond under mild conditions. The reaction exhibits good chemoselectivity and site-selectivity...
HFIP-Promoted Strain-Release-Driven Functionalization of Azabicyclo[1.1.0]butanes with Heterocyclobutane Trichloroacetimidates [0.03%]
HFIP促进的杂双环丁烷与氮杂并环丁烷的应变释放官能团化反应
Pujan Sasmal,Subhadeep Hazra,Thakar Neha Rajendra et al.
Pujan Sasmal et al.
We report the activation of oxetanyl, azetidinyl, and thietanyl trichloroacetimidates with 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), which rapidly couple with azabicyclo[1.1.0]butanes (ABB), following the Schmidt glycosylation strategy. The...