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Synthesis of Polycyclic Indolines via Spiroindolenines: Mechanistic Validation and HDAC6 Inhibition Potential

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A highly selective and acid-controlled method for the synthesis of functionalized pentacyclic indolines from tryptophols and o-aminobenzaldehydes is described. Preliminary mechanistic studies provide direct evidence of the involvement of a spiroindolenine inte... ...