Hong Sun,Duanyang Kong
Hong Sun
2-Quinolinones are key scaffolds in pharmaceuticals, yet their synthesis under mild and sustainable conditions remains challenging. We report a transition-metal-free C(sp2)-H lactamization of azido-alkenes using CO2 as a one-carbon source. ...
Photocatalytic SN2'-Type Mono-, Di-, and Trifluoromethylation of gem-Dichlorocyclobutenones [0.03%]
gem-二氯环丁烯酮的光催化SN2'-类型的单、双和三氟甲基化反应
Pinku Prasad Mondal,Sourav Das,Basudev Sahoo
Pinku Prasad Mondal
We report a metal-free photocatalytic SN2'-type trifluoromethylation of both β-alkyl- and β-aryl-gem-dichlorocyclobutenones using commercially available sodium trifluoromethylsulfinate. This mild and scalable method enables efficient acce...
Synthesis of α,β-Unsaturated Ketones from Aldehydes and Ketones Using 1,1-Di(boryl)alk-1-enes [0.03%]
醛和酮与1,1-二硼烯反应制备α,β不饱和酮
Hiro Takayanagi,Rikako Masui,Manami Mori et al.
Hiro Takayanagi et al.
An efficient method for the synthesis of α,β-unsaturated ketones through the boron-Wittig reaction of aldehydes and ketones using 1,1-di(boryl)alk-1-enes is reported. 1,1-Di(boryl)alk-1-enes are deprotonated at the γ-position to generate...
Biosynthesis of the l-Pyridylalanine Moiety in Antimycobacterial Pyridomycin via a PKS-NRPS Hybrid System [0.03%]
抗分枝杆菌吡哆霉素的L-吡啶丙氨酸结构域生物合成：PKS-NRPS杂合系统的参与
Haoran Du,Zihua Zhou,Shuang Han et al.
Haoran Du et al.
This study elucidates the de novo biosynthesis of 3-(3-pyridyl)-l-alanine (3-Pal), a key structural motif of the antimycobacterial cyclodepsipeptide pyridomycin, through a coordinated nonribosomal peptide synthetase-polyketide synthase (NRP...
Sijia Li,Hang Luo,Lei Gao et al.
Sijia Li et al.
Here we report a visible-light-driven copper-catalyzed arylamination of 1,3-butadiene using aryl iodides and amines. This method provides allylic amines in good yields with good chemo- and regioselectivity, as well as broad functional group...
DNA-Compatible Synthesis of β-Ketoamides as Intermediates for On-DNA Chemical Diversification [0.03%]
与DNA相容的β-酮酰胺合成及其作为DNA分子内化学修饰中间体的应用
Xianfeng Li,Zehao Yin,Qiuyi Chen et al.
Xianfeng Li et al.
The β-ketoamide motif represents both a privileged scaffold and a versatile synthetic intermediate in medicinal chemistry. Herein, we developed a DNA-compatible method for the efficient conversion of various DNA-conjugated amines into β-k...
Regioselective α-Addition of Deconjugated γ-Butenolides: Synthesis of Functionalized Dihydroquinolinones [0.03%]
脱共轭γ-丁内酯的区域选择性α加成反应：含功能基二氢喹啉酮衍生物的合成
Changhong Han,Hongli Wu,Tao Liu et al.
Changhong Han et al.
Regioselective reactions of γ-butenolides and the activation of an unactivated α-position represent a significant field of γ-butenolide chemistry. Compared with γ-addition, the regioselective α-addition of γ-butenolides has rarely bee...
Direct β-C(sp3)-H Functionalization to Carbonyls: A Route to Aldehydic Acid Derivatives [0.03%]
直接β-碳氢键官能团化反应制备醛酸衍生物
Koneti Kondalarao,Matteda Priyanka,Akhila K Sahoo
Koneti Kondalarao
We describe a general strategy for C═O bond formation through palladium-catalyzed β-C(sp3)-H functionalization using sulfoximine as a neutral directing group. This method enables chemoselective oxidation of inert β-C(sp3)-H bonds to alde...
Iron-Catalyzed Stereospecific Heterocycle N-Glycosylation with Glycal Epoxides [0.03%]
铁催化杂环N-糖基化反应中构型的控制：与环氧糖醛反应
Xiao-Wen Zhang,Dakang Zhang,Zixiang Jiang et al.
Xiao-Wen Zhang et al.
Stereospecific N-glycosylation of heterocycles with glycal epoxides could readily provide valuable building blocks for drug discovery, but heterocycle N-glycosylation with a pyranose-based glycal epoxide is still difficult using existing me...
Access to Hindered Homopropargylic Tertiary Alcohols via Nucleophilic Addition of Chiral Copper Species Forming an All-Carbon Quaternary Center [0.03%]
手性铜物种通过亲核加成进入受限的同胡泊尔基里三级醇形成全碳四级中心
Wan Seok Yoon,Jing He,Eunhye Pi et al.
Wan Seok Yoon et al.
We report the nucleophilic addition of chiral organocopper species derived from 1,3-enynes to carbonyl compounds, including ketones and aldehydes, providing efficient access to homopropargyl diols bearing an adjacent chiral all-carbon quate...