Biosynthesis of the l-Pyridylalanine Moiety in Antimycobacterial Pyridomycin via a PKS-NRPS Hybrid System
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This study elucidates the de novo biosynthesis of 3-(3-pyridyl)-l-alanine (3-Pal), a key structural motif of the antimycobacterial cyclodepsipeptide pyridomycin, through a coordinated nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) hybrid system... ...
