Iron-Catalyzed Radical-Mediated 1,3-Azidoalkylation of Bicyclo[1.1.0]butanes: Access to 1,1,3,3-Tetrasubstituted Cyclobutanes via Strain Release [0.03%]
铁催化自由基介导的双环[1.1.0]丁烷1,3-叠氮代基化：应变释放合成1,1,3,3-四取代环丁烷
Shanghui Tian,Kuan Zhang,Pengfei Li et al.
Shanghui Tian et al.
An iron-catalyzed proton-coupled electron transfer (PCET)-mediated radical 1,3-azidoalkylation of bicyclo[1.1.0]butanes (BCBs) with diazo compounds and TMSN3 is presented. Iron-catalyzed PCET activates diazo compounds to generate alkyl radi...
Bismuth-Catalyzed Photoinduced Ligand-to-Metal Charge Transfer (LMCT) Hydrodecarbonylation of Aldehydes [0.03%]
联苯催化光诱导配体到金属电荷转移(LMCT)醛的脱碳氧氢化反应
Lucas F Villela,Timothée Stoerkler,Liam Labbé et al.
Lucas F Villela et al.
Herein, we disclose a visible-light, bismuth-catalyzed strategy for the hydrodecarbonylation of aliphatic aldehydes. Mechanistic studies highlight chlorine radical formation via Ligand-to-Metal Charge Transfer (LMCT) from in situ generated ...
Nickel-Catalyzed Deallylation for Sustainable Solution and Solid-Phase Peptide Synthesis [0.03%]
镍催化去烯丙基化在可持续溶液相和固相肽合成中的应用
Maria Camila Aguilera,Steven W M Crossley,Renee J Sifri et al.
Maria Camila Aguilera et al.
We report a one-step, nickel-catalyzed allyl/alloc deprotection compatible with solid-phase peptide synthesis (SPPS) to address the reliance on costly palladium conditions and limited on-resin compatibility of base-metal alternatives. Our t...
Enriching Alkene syn-Dihalogenation: Aryl Alkene, Bromine, Regio-Reversion, and Stereoconvergency [0.03%]
烯烃顺式二卤化反应研究取得进展：芳基烯烃、溴源、位点反向及立体汇聚
Hyeon Moon,Juyeon Hong,Won-Jin Chung
Hyeon Moon
Alkene dihalogenation is widely utilized for organohalide synthesis as an indispensable synthetic tool. Ironically, the nearly perfect anti-diastereospecificity becomes a formidable hurdle when the other syn-diastereochemical course is desi...
Palladium-Catalyzed Enantioselective Tandem Allylation/Cyclization of ortho-Alkynylbenzaldehydes with Allyltrimethylsilane: Access to Chiral 1-Allyl-1 H-isochromenes [0.03%]
钯催化内消旋选择性连续偶联/环化反应生成ortho-丙炔基苯甲醛及 allyltrimethylsilane：手性的1-烯丙基-1H-异香豆素的合成路径研究
Meifen Wang,Lun Wang,Linchun Zhang et al.
Meifen Wang et al.
Herein, we report the first palladium-catalyzed asymmetric Sakurai-Hosomi-type tandem allylation/cyclization of ortho-alkynylbenzaldehydes with allyltrimethylsilane. A chiral Pd(II)/L11 complex combined with ZnCl2 and Cu(OAc)2 afforded 1-al...
Palladium-Catalyzed Dehydrogenative Annulation of Indolizines with Maleimides: Synthesis and Photophysical Studies of Maleimide-Fused Pyrrolo[2,1,5- cd]indolizines [0.03%]
钯催化吲哚嗪与马来酰亚胺的去氢环化反应：马来酰亚胺并吡咯并[2,1,5-cd]吲哚嗪的合成及光物理性质研究
Vani Dhyani,Pratiksha Jangir,Anil Kumar
Vani Dhyani
A palladium(II)-catalyzed (3+2) dehydrogenative annulation of indolizines with maleimides, providing a tetracyclic heterocyclic framework, is described. The developed protocol provides a variety of maleimide-fused pyrrolo[2,1,5-cd]indolizin...
Photocatalytic 1,2,3-Trifunctionalization of β,γ-Unsaturated Ketones via 1,2-Carbonyl Migration to Access Functionalized Indanones [0.03%]
光催化β, γ不饱和酮的1,2羰基迁移串联三官能化反应合成功能化茚酮类化合物
Shi-Gang Yan,Yi Li,Shuang Wu et al.
Shi-Gang Yan et al.
Rearrangement reactions are powerful tools in organic synthesis for the construction of new organic molecular scaffolds. Herein we report a photocatalytic radical-mediated 1,2-carbonyl migration of β,γ-unsaturated ketones with α-carbonyl...
Uncovering the Reactivity of Direct Photoredox Catalyzed α-C-H Alkylation of Alcohols: A Boron-Free Procedure [0.03%]
一种无需硼试剂的醇α位碳氢键官能团化反应的新方法
Geneviève F O&#x;Keefe,Dennis G Hall
Geneviève F O&#x;Keefe
Alcohol functionalization is an important class of pharmaceutically relevant transformations that have increasingly been achieved through photoredox-hydrogen atom transfer catalysis. Many methods rely on exogenous bond-weakening activators ...
Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent [0.03%]
T3P®作为绿色偶联试剂的环状叠氮
Priyanka Kushwaha,Marvin Mantel,Peter Talbiersky et al.
Priyanka Kushwaha et al.
Liquid-phase peptide synthesis (LPPS) continues to evolve toward more sustainable and efficient methodologies. In this study, we introduce Cyclover as a tag that enables efficient, tunable LPPS in 2Me-THF using propylphosphonic anhydride (T...
Photochemical Synthesis of DNA-Encoded 3 H-Azepines via Skeletal Editing of Nitroarenes [0.03%]
硝基芳烃结构编辑光化学合成DNA编码的3H氮杂环庚烷
Jia-Ying Xue,Jia-Hui Shi,Yuan Yao et al.
Jia-Ying Xue et al.
We report a skeletal editing strategy based on DNA-encoded nitroarenes for the direct conversion of benzene cores into valuable 3H-azepine scaffolds. This transformation is efficiently promoted by visible light in the presence of P(Oi-Pr)3,...