Palladium-Catalyzed Enantioselective Tandem Allylation/Cyclization of ortho-Alkynylbenzaldehydes with Allyltrimethylsilane: Access to Chiral 1-Allyl-1 H-isochromenes
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Herein, we report the first palladium-catalyzed asymmetric Sakurai-Hosomi-type tandem allylation/cyclization of ortho-alkynylbenzaldehydes with allyltrimethylsilane. A chiral Pd(II)/L11 complex combined with ZnCl2 and Cu(OAc)2 afforded 1-allyl-1H-isochromenes ... ...
