A Novel Heat-Resistant Energetic Material: Pyrazolopyrimidine-Bistetrazole Compound [0.03%]
一种新型耐热高能材料：吡唑并嘧啶双叠氮茋化合物
Zhaodong Tang,Teng Zhu,Chengchuang Li et al.
Zhaodong Tang et al.
Nowadays, nitrogen-rich tetrazole is the key research object due to high heats of formation in energy materials, but low thermal stability limits its widely application. Herein, two tetrazole groups were introduced to the fused ring backbon...
Chirality in Abundance: A Reagent-Controlled Access to Multiple Stereoisomers of Functionalized Bishomocubanes [0.03%]
丰富的对映体：通过试剂控制获得官能化双半 chair 立构异构体的途径
Gangavara L Tejashree,Argha Bhattacharjee,Irishi N N Namboothiri
Gangavara L Tejashree
Efficient access to enantiopure polycyclic cage compounds is a challenging but attractive objective. The 1,3-bishomocubane (BHC) skeleton, in particular, is distinguished by its chirality, exceptional configurational and conformational rigi...
Access to Imidazolidin-2-ones via Azocarboxamide-Enabled Enantioselective 1,2-Diamination of Aldehyde [0.03%]
亚胺茋类化合物的合成及其对小鼠脑缺血再灌注损伤保护作用的研究
Feng-Lin Li,Yun-Dong Fu,Can Luo et al.
Feng-Lin Li et al.
The catalytic asymmetric synthesis of imidazolidin-2-ones has attracted widespread attention due to their diverse synthetic applications. Despite the great progress that has been made, the development of a straightforward, operationally sim...
Pd(II)-Catalyzed Hydroxyl-acyloxylation of gem-Dimethyl Groups via Dual C(sp3)-H Activation [0.03%]
通过双重C(sp3)-H活化对gem-二甲基进行羟基酯氧化反应的Pd(II)催化方法
Xiaorui Song,Zhenzhen Dong,Miaomiao Tian et al.
Xiaorui Song et al.
Herein, we report a one-pot dual oxyfunctionalization reaction of ubiquitous gem-dimethyl groups using a single Pd(II)/Pd(IV) catalytic system, achieving both hydroxyl-acyloxylation and diacetoxylation by employing N-pyridine ylide as a dir...
Yue Li,Hao Wei,Jiaxi Xu et al.
Yue Li et al.
Harnessing sterically controlled and rare-earth-catalyzed chemodivergent (3 + 3) annulations between enamines and Achmatowicz rearrangement products (ARPs), we provide practical methods for efficiently constructing two types of highly funct...
Palladium-Catalyzed Cascade Reaction of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: One-Step Access to 2-Fluorocarbazoles [0.03%]
钯催化吲哚与α,α-二氟-β,γ-不饱和酮的级联反应：一步构建2-氟咔唑类化合物
Chunming Chen,Zhenli Luo,Mei Xie et al.
Chunming Chen et al.
A practical synthesis of pharmacologically and materially relevant fluorinated carbazoles is highly desirable yet remains challenging. Herein, we report an efficient route to 2-fluorocarbazoles via a Pd(0)/Cu(I)-cocatalyzed tandem reaction ...
An Unexpected Isomerization for the Total Synthesis of Daphnepapytone A [0.03%]
出人意料的异构化反应在苦皮藤素A全合成中的应用
Ilja Lubins,Bernhard Breit
Ilja Lubins
We report a high-yielding total synthesis of sesquiterpenoid daphnepapytone A from (S)-glycidol. The groundwork for the synthesis is laid via reductive cleavage of a bicyclic Pauson-Khand-derived cyclopentenone ether, giving efficient acces...
Catalytic Asymmetric Kinetic Resolution of 2,2-Disubstituted Styrenyl Aziridines via Ring Opening with Amines [0.03%]
通过与胺类化合物开环的动态动力学拆分催化性不对称合成2,2-二取代的茋
Pei-Jun Yang,Hu Zhang,Guo-Sheng Zhu et al.
Pei-Jun Yang et al.
We report herein the activation of racemic 2,2-disubstituted styrenyl aziridines by Lewis acid catalysis to undergo ring-opening reactions at a tertiary carbocenter via kinetic resolution with amines. A range of chiral diamine products bear...
Desymmetrization and Atroposelective Cobalt Catalyzed C-H Annulation of Phosphinic Amides with Ynamides [0.03%]
手性钴催化膦酸酰胺与炔胺的C-H环化反应及其动力学拆分
Somratan Sau,Abid Ali,Koushik Pradhan et al.
Somratan Sau et al.
Metal-catalyzed asymmetric C-H annulation enables enantioselective synthesis from simple precursors, but methods that simultaneously generate multiple stereogenic elements in a single step remain rare. We report the first Co(II)/Salox-catal...
Pratap Kumar Mandal,Subhra Kanti Mahato,Soumalya Panja et al.
Pratap Kumar Mandal et al.
Herein, a sterically induced reactivity switch has been developed to achieve the allenal reactivity rather than the classical copper-allenylidene reactivity of cyclic ethynylethylene carbonates (EECs). This copper-catalyzed protocol furnish...