Access to Se/S-Containing Heterocycles via Hexafluoroisopropanol-Mediated Tandem Wolff Rearrangement/Cyclization [0.03%]
六氟异丙醇介导的伍德华重排/环化串联反应制备含硒/硫杂环化合物
Yihan Yu,Xin Ji,Xingxing Wu et al.
Yihan Yu et al.
Herein, we report a novel and efficient formal [3 + 3] cyclization strategy for the synthesis of 1,3-selenazines. This protocol relies on the hexafluoroisopropanol (HFIP)-mediated Wolff rearrangement of alkynyl diazoalkyl ketones to in situ...
Photoredox/Copper Dual-Catalyzed Four-Component Regioselective 1,2-Arylsulfonylation of Vinylarenes [0.03%]
光红氧化学说/铜双催化乙烯基芳烃的区域选择性1,2-芳磺化反应
Yunyi Zhang,Lingyu Shi,Patiman Turgun et al.
Yunyi Zhang et al.
Sulfones and their derivatives serve as important structural units in organic chemistry. However, there is currently a lack of simple and feasible synthetic methods for their synthesis. In this wotk, a photoredox/copper dual catalysis that ...
Copper-Catalyzed Amino-alkoxycarbonylation of Unactivated Alkenes: Synthesis of β-Amino Esters via Primary Tosyl Amidyl Radical [0.03%]
铜催化未活化烯烃的氨基醇氧羰基化反应：通过一次托磺酰胺自由基合成β-氨基酸酯
Xudong Mao,Ming Hou,Yuanrui Wang et al.
Xudong Mao et al.
β-Amino acids serve as essential motifs in a wide array of bioactive compounds, pharmaceuticals, and natural products, playing a crucial role in the development of peptides and peptidomimetics. Transition-metal-catalyzed carbonylative func...
Rhodium-Catalyzed Reductive Carbonylative Cyclization of Aryl Alkynes with Hydrosilanes via C-H Activation to Access Silyl-Substituted Indanones [0.03%]
通过C-H活化和含硅试剂的还原性羰基化环化反应合成茚酮类化合物
Fengxiang Zhu,Mengdi Zhou,Xiao-Feng Wu
Fengxiang Zhu
A rhodium-catalyzed reductive carbonylative cyclization for the direct synthesis of 3-silyl-1-indanones from readily available aryl alkynes and hydrosilanes is described. This transformation concurrently introduces a silicon moiety and cons...
Discovery and Engineering Imine Reductase for Gram-Scale Synthesis of (S)-Nicotine [0.03%]
用于克级手性尼古丁合成的亚胺还原酶的挖掘和工程研究
Shifeng Zhang,Yuting Zou,Hongkui Wang et al.
Shifeng Zhang et al.
An engineered imine reductase variant capable of synthesizing (S)-nicotine was developed through structure-guided directed evolution. Enzyme library screening identified IR-55 as an ideal parent, exhibiting high yield and good enantioselect...
pNZ Removal Aided Aqueous Solid-Phase Peptide Synthesis: A Gateway to Sustainable Synthesis of Complex Peptides [0.03%]
用于可持续合成复杂肽的液固相肽合成：去除pNZ助剂的路径
Jan Pawlas
Jan Pawlas
For decades, chemists have followed Nature's lead, developing methods to make peptides in water. For the aqueous variant of the ubiquitous solid-phase peptide synthesis (ASPPS) in particular, significant advances have been reported, albeit ...
Photocatalytic Perfluoroalkenylation of Ketones and Its Application in the Synthesis of Fluorinated Heterocycles [0.03%]
酮的光催化全氟烯基化及其在含氟杂环合成中的应用
Max M Schreier,Constantin Czekelius
Max M Schreier
A mild and efficient photocatalytic method for the α-perfluoroalkenylation of ketones via the corresponding enol silanes has been developed. Using a commercial ruthenium photocatalyst and DABCO under visible light irradiation, perfluoroeno...
Savva Ponomarev,Sandra W Papińska,Michael Stier et al.
Savva Ponomarev et al.
CuCl-induced cyclopropyl alcohol ring-opening followed by β-acylation with thioester is reported. Cyclopropanols and thioesters with various substitution patterns were successfully subjected to the reaction, and a series of 1,4-dicarbonyl ...
Accelerated Mining of Extremophile Natural Products: An Integrated Omics Approach Captures Antiviral Lipopeptides [0.03%]
极端嗜好菌天然产物的加速挖掘：整合组学方法捕获抗病毒脂肽
Suling Xu,Wenjie Ma,Yueting Zhang et al.
Suling Xu et al.
Using a combined culturomics-driven activation and metabologenomics approach, a new family of lipopeptides, nocardins A-E (1-5, respectively), were identified and isolated from Arctic-derived Nocardia sp. L016. Their planar structures and a...
Studies on Metastable Heterocycles: 2-Formyl-3-methylene-1-pyrroline [0.03%]
亚稳定杂环化合物的研究：2-甲醛-3-甲基烯基-1-吡咯啉
Aleksandras Lotuzas,Ashley A Michel,Patrick G Harran
Aleksandras Lotuzas
A Staudinger-based synthesis of a stable acylal precursor to 2-formyl-3-methylene-1-pyrroline has been developed. Subsequent acetyl transfer to phenoxide in dry THF generates a mono acetyl potassium hemiacetal that decomposes to the target ...