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Accelerated Mining of Extremophile Natural Products: An Integrated Omics Approach Captures Antiviral Lipopeptides

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Using a combined culturomics-driven activation and metabologenomics approach, a new family of lipopeptides, nocardins A-E (1-5, respectively), were identified and isolated from Arctic-derived Nocardia sp. L016. Their planar structures and absolute configuratio... ...