Radiopharmaceutical therapy provides superior survival advantage for leptomeningeal metastasis compared to external beam radiotherapy [0.03%]
放射性药物治疗较外部束放射治疗对脑膜转移癌的生存优势更佳
Lei Zhao,Paul A Clark,Jack M Shireman et al.
Lei Zhao et al.
Background: Leptomeningeal metastasis from a solid tumor carries a dismal prognosis with median survival of 3 to 5 months after diagnosis and treatment with external beam radiation therapy. It targets the whole-brain or t...
Nuclear export as a therapeutic vulnerability in ZFTA-RELA ependymoma [0.03%]
ZFTA-RELA 基因融合室管膜瘤的治疗新靶点——核输出路径
Siri M Ippagunta,Amir Arabzade,Srinidhi Varadharajan et al.
Siri M Ippagunta et al.
Background: Ependymoma (EPN) is the third most common pediatric brain tumor with no targeted therapies available to patients. In supratentorial ependymoma, the most frequent driver alteration is a gene fusion between ZFTA...
5-ALA-mediated PpIX Accumulation in the Tumor Microenvironment of Glioma and its Implications for 5-ALA-based Local Tumor Therapies: A Review of the Literature [0.03%]
5-氨基乙酰丙酸介导的胶质瘤肿瘤微环境中原卟啉 IX 蓄积及其对基于 5-氨基乙酰丙酸局部肿瘤治疗的意义：文献综述
Zeynep Özdemir,Marco Gallus,Michael Müther et al.
Zeynep Özdemir et al.
5-Aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) accumulation is widely used for fluorescence-guided surgery in malignant glioma. Beyond its diagnostic role, PpIX exhibits photo-, sono-, and radiosensitizing properties that en...
Expanding the scope of collective responsibility in neuro-oncology: the integrity of the published record [0.03%]
神经肿瘤学中集体责任范围的扩大：发表记录的完整性
Timothy Daly,Jaime A Teixeira Da Silva
Timothy Daly
Modeling Gliomas with Organoids: Classification, Fidelity, and Guidelines for Translational Neuro-Oncology [0.03%]
用类器官模拟胶质瘤：分类、保真度和转化神经肿瘤学指南
Christopher G Hubert,Renee D Read,Tyler E Miller et al.
Christopher G Hubert et al.
Advances in organoid technology have transformed how gliomas are modeled and studied. Recent FDA and NIH initiatives further promote human-relevant organoid platforms for preclinical research. Glioma organoids can be broadly categorized int...
NEU1 Sustains Mitochondria-Lysosome Contacts to Trigger Lysosomal Cu²⁺/Cathepsin Escape and Mitochondrial lysis in Glioblastoma (NeuLysis) [0.03%]
NEU1维持线粒体-溶酶体接触以触发溶酶体Cu²⁺/天冬氨酸蛋白酶逃逸和胶质母细胞瘤中线粒体崩解(神经分解)
Yanping Huang,Dongyuan Su,Xiaoteng Cui et al.
Yanping Huang et al.
Background: Mitochondria-lysosome contacts regulates metabolic reprogramming in cancer, yet its role in glioblastoma pathogenesis remains poorly defined. ...
Glo1 promotes glioma progression by modulating Sox2 transcriptional networks in glioma stem-like cells [0.03%]
Glo1通过调节少突胶质细胞瘤干细胞样细胞中的Sox2转录网络促进少突胶质细胞瘤进展
Dong-Joo Choi,Yeunjung Ko,Peihao He et al.
Dong-Joo Choi et al.
Background: Glioma stem cells (GSCs) contribute to tumor heterogeneity and are resistant to conventional therapies, making them a significant obstacle to achieving long-term treatment success. However, efforts to eliminat...
Prospective biopsy-controlled validation of an AI model for predicting glioblastoma infiltration: Results from the SupraGlio trial [0.03%]
SupraGlio研究：前瞻性活检验证用于预测胶质母细胞瘤浸润的AI模型
Santiago Cepeda,Elena Hernando-Pérez,Enrique Pérez-Riesgo et al.
Santiago Cepeda et al.
Background: Glioblastoma recurrence is driven by diffuse microscopic infiltration beyond the contrast-enhancing tumour margin. GlioMap is an open-access AI model predicting voxelwise infiltration and recurrence risk from ...
Improved coping and self-efficacy drive improvements in mood among caregivers of patients with primary malignant brain tumors: Results from an RCT [0.03%]
改善应对和自我效能感提升护工的情绪：一项关于原发恶性脑肿瘤患者的随机对照试验结果
Kelcie D Willis,Deborah A Forst,Nora Horick et al.
Kelcie D Willis et al.
Background: In a recent randomized controlled trial, caregivers of patients diagnosed with primary malignant brain tumors (PMBT) who received NeuroCARE-a six-session, cognitive-behavioral, telehealth intervention-demonstr...
Point/counterpoint: The use of perfusion-weighted MRI and amino acid PETfor the identification of treatment-related changes [0.03%]
观点与反论：灌注加权MRI和氨基酸PET在检测治疗相关改变中的应用
Norbert Galldiks,Philipp Lohmann,Jan-Michael Werner et al.
Norbert Galldiks et al.