CD155 regulates tumor growth and susceptibility to T cell mediated killing in diffuse midline glioma [0.03%]
CD155通过调节弥漫性中线胶质瘤的生长和对T细胞介导杀伤的敏感性发挥肿瘤抑制功能
Theophilos Tzaridis,Ester Calvo Fernández,Tanja Eisemann et al.
Theophilos Tzaridis et al.
Background: Diffuse midline glioma (DMG) is a devastating pediatric brain tumor with an unmet need for novel therapies. Immune checkpoint inhibitors have failed to prolong survival of DMG patients. ...
Potent anti-tumor preclinical efficacy of B7-H3 CAR-T cells in H3G34-mutant, Diffuse Hemispheric Glioma [0.03%]
B7-H3 CAR-T细胞对H3G34突变弥漫半球胶质瘤的高效抗肿瘤作用（离体）
David Akhavan,Monika Yadav,Siddharth Subham et al.
David Akhavan et al.
Background: Diffuse hemispheric glioma (DHG), H3 G34-mutant, is a highly aggressive and fatal pediatric brain tumor, with a median survival of only ∼18 months and no effective targeted therapies. While CAR T cell therapy...
Stereotactic Radiosurgery Outcomes for Radiation-Induced Meningiomas After Childhood Tinea Capitis Irradiation: A Comparative Study with Sporadic Meningiomas [0.03%]
立体放射外科治疗头癣放疗后引起的放射诱发脑膜瘤的预后与散发性脑膜瘤的比较研究
Ofir Sholy Ben-Mouel,Shachar Zion Shemesh,Guy Dumanis et al.
Ofir Sholy Ben-Mouel et al.
Background: Childhood scalp irradiation for tinea capitis (TC) increases the long-term risk of intracranial meningiomas. It remains unclear whether prior TC irradiation affects meningiomas' response to stereotactic radios...
A Shared Neoantigen Comes of Age: Lessons from Long-Term Follow-up of IDH1 Vaccination [0.03%]
同工共济：IDH1疫苗长期随访的经验与教训
Junya Yamaguchi,Jennie W Taylor,Hideho Okada
Junya Yamaguchi
Siglec-15 and PD-1 checkpoint blockade in combination with oncolytic Zika virus infection confers protection against immune-resistant gliomas [0.03%]
Siglec-15和PD-1检查点阻断联合溶瘤寨卡病毒感染对免疫抵抗胶质瘤的保护作用
Ashwani Kesarwani,Amber Neil Griffith,Sonam Verma et al.
Ashwani Kesarwani et al.
Background: : The glioblastoma (GBM) immunosuppressive tumor microenvironment is a clinical challenge. Oncolytic Zika virus (ZIKV) has emerged as a promising therapy, targeting treatment-resistant glioma stem cells, stimu...
Siglec-15 and PD-1 checkpoint blockade in combination with oncolytic Zika virus infection confers protection against immune-resistant gliomas [0.03%]
人源肿瘤异种移植小鼠模型中联合应用靶向Siglec-15和PD-1的免疫疗法及溶瘤寨卡病毒感染可抑制“免疫抵抗”型胶质母细胞瘤生长
Ashwani Kesarwani,Amber Neil Griffith,Sonam Verma et al.
Ashwani Kesarwani et al.
Background: : The glioblastoma (GBM) immunosuppressive tumor microenvironment is a clinical challenge. Oncolytic Zika virus (ZIKV) has emerged as a promising therapy, targeting treatment-resistant glioma stem cells, stimu...
Seema Nagpal,Brandon Carlson-Clarke,Sahara S Rout et al.
Seema Nagpal et al.
Background: Leptomeningeal disease (LMD) is a devastating complication of metastatic breast cancer that leads to severe neurologic symptoms and a poor prognosis. Current treatment options, including radiation and intrathe...
Focused ultrasound to track circulating extracellular vesicles in glioblastoma [0.03%]
聚焦超声追踪胶质母细胞瘤循环外泌体
Mahmoud Elguindy,David R Raleigh
Mahmoud Elguindy
Estradiol Reprograms Microglia to Create an Immune‑Suppressed Niche Permissive to Breast Cancer Brain Metastasis [0.03%]
雌二醇重新编程小胶质细胞以创建免疫抑制微环境从而允许乳腺癌脑转移发生
Karen L F Alvarez-Eraso,María J Contreras-Zárate,Andrew Goodspeed et al.
Karen L F Alvarez-Eraso et al.
Background: Young age is an independent risk factor for the development of breast cancer brain metastases (BM). Prior work showed that 17β-estradiol (E2), the predominant premenopausal hormone, promotes BM of tumors intr...
An Integrated Transcriptional and Post-Transcriptional Regulatory Circuit Orchestrated by NUDT21 Maintains the Proliferation and Survival of Neuroblastoma [0.03%]
NUDT21调控的转录和转录后整合调控电路维系神经母细胞瘤的增殖和生存能力
Yang Yang,Chunxia Shi,Jianwei Wang et al.
Yang Yang et al.
Background: Neuroblastoma (NB) is the most prevalent pediatric solid tumor, associated with a poor prognosis. While alternative polyadenylation (APA) is a key post-transcriptional regulatory mechanism in many cancers, its...