Single-Fraction Stereotactic Radiosurgery for Residual, Recurrent, or Metastatic Intracranial Solitary Fibrous Tumors: An IRRF Study Toward Management Guidance [0.03%]
单次分割立体定向放射外科治疗颅内孤立性纤维肿瘤的残留、复发或转移病灶：关于管理指南的IRRF研究
Salem M Tos,Ahmed Shaaban,Dawood Hamdan et al.
Salem M Tos et al.
Background: Intracranial solitary fibrous tumors (SFTs) are rare, aggressive neoplasms with high local recurrence. This study evaluates the efficacy and prognostic factors of single-fraction stereotactic radiosurgery (SRS...
Integrated immune profiling of chordomas reveals spatially organized niches and functional heterogeneity [0.03%]
整合的免疫谱分析显示软骨肉瘤具有空间组织生态位和功能异质性
Victor A Arrieta,J Kada Benotmane,Rebecca Du et al.
Victor A Arrieta et al.
Background: Chordomas are locally aggressive notochordal tumors with no systemic therapy options. As an ultra-rare cancer type, our understanding of its immune landscape is limited. While tumor-associated macrophages (TAM...
Response: Methodological Considerations for Large Language Model-Based Symptom Extraction in Neuro-Oncology Electronic Health Records [0.03%]
基于大型语言模型的神经肿瘤电子健康记录症状提取方法学考虑
John Y Rhee,Thomas Sounack,Rameen Beroukhim et al.
John Y Rhee et al.
Methodological Considerations for Large Language Model-Based Symptom Extraction in Neuro-Oncology Electronic Health Records [0.03%]
基于大型语言模型的神经肿瘤电子健康记录症状提取方法学考虑因素
Xindi Wang,Zhaoxin Chang,Hao Dong et al.
Xindi Wang et al.
Cognitive Function, Quality of Life, and Survival Outcomes in Patients with Lower Grade Gliomas Treated with Proton Radiation Therapy: A Phase II study [0.03%]
质子放射治疗低级别胶质瘤患者的认知功能、生活质量及生存结果：一项II期研究
Jason M Slater,Nora K Horick,Lisa B Nachtigall et al.
Jason M Slater et al.
Background: Lower grade gliomas (LGGs) typically affect younger adults and are associated with long-term survival. Treatment-related toxicities, especially neurocognitive and neuroendocrine effects, are a concern. Proton ...
Soluble E-cadherin-CXCL1-CXCR2 Axis as a Therapeutic Vulnerability in Inflammatory Breast Cancer Brain Metastasis [0.03%]
可溶性E-钙黏蛋白-CXCL1-CXCR2轴作为炎症型乳腺癌脑转移的治疗弱点
Xiaoding Hu,Yun Xiong,Emilly S Villodre et al.
Xiaoding Hu et al.
Background: The brain is a common site of relapse in inflammatory breast cancer (IBC), an E-cadherin-positive, aggressive form of breast cancer. Elevated serum levels of soluble E-cadherin (sEcad), an 80-kDa fragment, cor...
Intracranial mesenchymal tumor, FET::CREB fusion-positive: an integrative analysis of 81 cases [0.03%]
颅内间叶源性肿瘤FET::CREB融合阳性：81例综合分析
Sharika Rajan,Hye-Jung Chung,Zhichao Wu et al.
Sharika Rajan et al.
Background: Intracranial mesenchymal tumors, FET::CREB fusion-positive (ICMT), show fusions involving FET RNA-binding protein family genes (EWSR1 or FUS) and CREB family of transcription factors (ATF1, CREB1 or CREM). The...
Investigator-led clinical trial of boron neutron capture therapy system for recurrent high-grade meningiomas after radiation therapy: Randomized phase II study [0.03%]
复发放射抵抗性高分级脑膜瘤患者用硼中子俘获疗法治疗的随机II期临床研究
Hideki Kashiwagi,Masahiko Wanibuchi,Naokado Ikeda et al.
Hideki Kashiwagi et al.
Background: High-grade meningiomas (HGMs) recurring after X-ray treatment show poor prognosis. We assessed the effectiveness and safety of boron neutron capture therapy (BNCT) in patients with refractory recurrent HGMs. ...
Ibrutinib in combination with rituximab, methotrexate, vincristine, and procarbazine (R-MVP/i) for newly diagnosed primary CNS lymphoma (PCNSL) [0.03%]
伊布替尼联合利妥昔单抗、甲氨蝶呤、长春花碱和丙卡巴肼（R-MVP/i）治疗新诊断的原发中枢神经系统淋巴瘤（PCNSL）
Lauren R Schaff,Elena Pentsova,Rachna Malani et al.
Lauren R Schaff et al.
Background: High-dose methotrexate (MTX)-based chemotherapy is the mainstay of treatment of primary central nervous system lymphoma (PCNSL). Only ∼60% of patients achieve a complete response to first line therapy with fr...
KMT2A is a prerequisite of malignant transformation during IDH-mutant gliomagenesis [0.03%]
IDH突变型胶质瘤发生过程中KMT2A是恶性转化的必要条件
Marilin S Koch,Minh Deo,Claudia Schmidt et al.
Marilin S Koch et al.
Background: IDH1R132H is the defining mutation of low-grade gliomas (LGGs), inflicting broad epigenetic rewiring that leads to malignant transformation. Recent studies demonstrated that cell fate change from astrocyte to ...