Beyond the hippocampus: Limbic white matter injury implicated in post-radiation memory performance in primary brain tumor patients [0.03%]
海马体之外：放射性继发白质损伤与原发脑肿瘤患者的记忆表现密切相关
Alexander S Qian,Roshan Karunamuni,Soumya Unnikrishnan et al.
Alexander S Qian et al.
Background: Limbic white matter (WM) of the Papez circuit, including the fornix, dorsal cingulum, and parahippocampal cingulum (PHC), interplay with the hippocampus as key components of the memory network. We analyzed bio...
Novel GABAAR antagonists target networked gene hubs at the leading-edge in high-grade gliomas [0.03%]
新型GABA受体拮抗剂靶向高级别胶质瘤前沿的基因网络中心节点
Chloe Shard,Anya C Jones,Anahita Fouladzadeh et al.
Chloe Shard et al.
Background: Ion channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG p...
Erratum to: Phase 1 dose-escalation trial using convection-enhanced delivery of radio-immunotheranostic 124I-Omburtamab for diffuse intrinsic pontine glioma [0.03%]
放射免疫诊疗显像剂124I-Omburtamab血管输注给药治疗弥漫性内生脑桥胶质瘤Ⅰ期爬坡剂量临床试验的更正公告
Published Erratum
Neuro-oncology. 2025 Jun 9:noaf138. DOI:10.1093/neuonc/noaf138 2025
Phase 3 randomized trial of high-dose methotrexate for young children with high-risk embryonal brain tumors: A report from the Children's Oncology Group [0.03%]
儿童脑瘤高危胚胎肿瘤高剂量甲氨蝶呤三期随机试验：儿童癌症研究组报告
Claire Mazewski,Sarah E S Leary,Guolian Kang et al.
Claire Mazewski et al.
Background: Embryonal brain tumors are the leading cause of cancer death in young children. Methods: ACNS0334 was a phase 3 randomized ...
Nuclear cholesterol regulates nuclear size and DNA damage responses in cancer stem cells [0.03%]
胆固醇核受体调节癌症干细胞中的核大小和DNA损伤反应
Tingting Duan,Suchet Taori,Shruti Bhargava et al.
Tingting Duan et al.
Background: Nuclear atypia is associated with increased malignancy in numerous cancers, including glioblastoma (GBM). Here, we found that GBM stem cells display small nuclear size, prompting investigation of mechanisms un...
TUXEDO-3: A phase 2 trial of patritumab deruxtecan for patients with leptomeningeal metastasis [0.03%]
TUXEDO-3：德鲁替康帕妥珠单抗治疗脑膜转移患者II期临床试验
Emilie Le Rhun,Enrico Franceschi,Michael Weller
Emilie Le Rhun
Unraveling the Effects of Radiotherapy on the Blood Brain Barrier: Fact or Fiction? [0.03%]
放射治疗对血脑屏障影响的真相：确有其事还是无稽之谈？
Rupesh Kotecha,Minesh P Mehta
Rupesh Kotecha
Impact of corticosteroid administration on contrast-enhancing volume and diffusion MRI in treatment naïve glioblastoma [0.03%]
糖皮质激素对初治胶质母细胞瘤增强磁共振及弥散加权磁共振的影响研究
Francesco Sanvito,Asher Kim,Catalina Raymond et al.
Francesco Sanvito et al.
Background: Corticosteroids impact the radiographic interpretation of glioblastoma, including artificial reduction in contrast-enhancing tumor volume and intensity (i.e., a "pseudoresponse") and in the apparent coefficien...
Clinical, molecular and radiological predictors of prognosis in newly diagnosed astrocytoma, IDH-mutant, WHO grade 4 [0.03%]
新诊断的IDH突变型IV级胶质瘤预后预测的临床、分子和影像标志物
Aleksandra B Lasica,Zhou Lan,Julie J Miller et al.
Aleksandra B Lasica et al.
Background: Astrocytoma, isocitrate dehydrogenase-mutant, WHO grade 4 (Astro4), is a new tumor type in the 2021 WHO classification of central nervous system tumors that has been poorly characterized in the literature. Thi...
Glioblastoma-enriched glycosphingolipids modulate the function of human iNKT cells [0.03%]
胶质母细胞瘤富集的糖脂改变人iNKT细胞功能
Morgan J Coombs,Tyrone Dowdy,Md Masud Alam et al.
Morgan J Coombs et al.
Background: To develop effective therapies for glioblastoma (GBM), a deeper understanding of its underlying immunoregulatory mechanisms is needed. Invariant natural killer T (iNKT) cells are unconventional T cells that re...