An Integrated Transcriptional and Post-Transcriptional Regulatory Circuit Orchestrated by NUDT21 Maintains the Proliferation and Survival of Neuroblastoma [0.03%]
NUDT21调控的转录和转录后整合调控电路维系神经母细胞瘤的增殖和生存能力
Yang Yang,Chunxia Shi,Jianwei Wang et al.
Yang Yang et al.
Background: Neuroblastoma (NB) is the most prevalent pediatric solid tumor, associated with a poor prognosis. While alternative polyadenylation (APA) is a key post-transcriptional regulatory mechanism in many cancers, its...
Intracerebroventricular B7-H3-targeting CAR T cells for non-pontine DMG and recurrent/refractory pediatric CNS tumors: a phase 1 trial [0.03%]
针对非桥小脑角DMG和复发/难治性儿童中枢神经系统肿瘤的脑室内B7-H3靶向CAR-T细胞治疗：一项I期试验
Rebecca Ronsley,Wenjun Huang,Ethan Rohlf et al.
Rebecca Ronsley et al.
Background: High-grade central nervous system (CNS) tumors carry a poor prognosis with limited curative options if first-line therapy fails. B7-H3 is expressed in many of these tumors, and chimeric antigen receptor (CAR) ...
Methodological considerations in the assessment of hemizygous CDKN2A/B deletions in meningioma and IDH-mutant glioma [0.03%]
评估脑膜瘤和IDH突变型胶质瘤中CDKN2A/B半合子缺失的方法学考虑因素
Franziska M Ippen,Felix Sahm,Abigail K Suwala
Franziska M Ippen
The prognostic value of CDKN2A/CDKN2B hemizygous deletion in meningioma remains uncertain [0.03%]
CDKN2A/CDKN2B半单倍体缺失在脑膜瘤中的预后价值仍不确定
Junpeng Ma,Wei Chen,Yaqiang Hong et al.
Junpeng Ma et al.
A PTX3/TLR4 axis sustains SHH-Medulloblastoma growth and defines a new therapeutic vulnerability [0.03%]
PTX3/TLR4信号轴通过促进SHH型髓母细胞瘤的生长而使其持续存在并可作为新的治疗靶点
Serena Filiberti,Camilla Tavani,Elena Somenza et al.
Serena Filiberti et al.
Background: Sonic hedgehog-medulloblastoma (SHH-MB) represents a biologically diverse and clinically challenging subgroup, especially in high-risk variants characterized by metastatic dissemination. Despite progress in mo...
Early increase in apparent diffusion coefficient predicts favorable response to Dordaviprone (ONC201) therapy in H3K27M-mutant diffuse midline glioma [0.03%]
表观扩散系数早期升高预示H3K27M突变弥漫中线胶质瘤患者Dordavi-prone（ONC201）治疗反应良好
Benison C Lau,Diala P Ajaero,Benjamin A Hoff et al.
Benison C Lau et al.
Background: Dordaviprone (ONC201) is the first FDA-approved therapy for H3K27M-mutant diffuse midline glioma (DMG). However, therapeutic response varies among patients, and no imaging biomarkers currently predict long-ter...
Carboplatin induces optic nerve oligodendrocyte loss and impairs myelin sheath microstructure in a mouse model of neurofibromatosis type 1 (NF1) [0.03%]
卡铂诱发神经纤维瘤病I型小鼠模型视神经少突胶质细胞丢失并损害髓鞘微结构
Benjamin E Aghoghovwia,Kechen Ban,Dimitrios Stavropoulos et al.
Benjamin E Aghoghovwia et al.
Background: Vision impairment is a significant concern for children with Neurofibromatosis type 1 (NF1)-associated optic pathway glioma (OPG). While carboplatin-containing chemotherapy is often first-line therapy for NF1-...
Professional Grief, Burnout and Coping among Neuro-Oncologists: A Cross-Sectional Online Study (PROGRESS) [0.03%]
神经肿瘤学家的专业悲伤、职业耗竭及其应对机制：一项横断面在线研究（专业进步研究）
Raphael Detchev,Maximilian Scheer,Christoph Oster et al.
Raphael Detchev et al.
Background: Physicians treating patients with malignant central nervous system tumors frequently experience patient deaths, yet the impact of professional grief on burnout has not been examined in neuro-oncology. This stu...
Programmable microfluidic modeling of the glioblastoma immune microenvironment recapitulates temporally regulated tumor-immune signaling [0.03%]
可编程微流体模拟胶质母细胞瘤免疫微环境以重现肿瘤免疫信号的动态变化规律
Seokgyu Han,Yona Kim,Sein Kim et al.
Seokgyu Han et al.
Background: Glioblastoma (GBM) progression is driven by intricate interactions between neoplastic cells and immune populations within the tumor microenvironment (TME), yet the temporal organization of these processes rema...
The CoREST complex inhibitor, corin, decreases tumor growth, increases cellular differentiation and extends lifespan in ATRT xenograft models [0.03%]
CoREST复합物抑制剂corin能降低ATRT异种移植模型的肿瘤生長、提高細胞分化并延長壽命
Anupa Geethadevi,Nikhil Vaidya,Robert J Fisher et al.
Anupa Geethadevi et al.
Background: Atypical teratoid rhabdoid tumor (ATRT) is the most common malignant brain tumor in infants. ATRT is associated with inactivation/deletion of SMARCB1, a member of the SWI/SNF chromatin remodeling complex. SMAR...