BRAF-altered glioma in adults and children: A Society for Neuro-Oncology (SNO) and European Society for Neuro-Oncology (EANO) consensus review on clinical management and future directions [0.03%]
成人和儿童BRAF基因突变型胶质瘤的临床管理及未来发展方向共识意见（美国神经肿瘤学会和欧洲神经肿瘤学组）
Karisa C Schreck,Macarena I de la Fuente,Mary Jane Lim Fat et al.
Karisa C Schreck et al.
Oncogenic BRAF alterations occur in a subset of diffuse gliomas across WHO grades and are increasingly identified through modern molecular diagnostics. In addition to standard glioma therapies, targeted treatments are available for patients...
Genomic hallmarks of depot medroxyprogesterone acetate-associated meningiomas [0.03%]
甲孕酮醋酸酯致垂体膜状瘤的基因组特征
Sakibul Huq,Taylor A Gatesman,Hussam Abou-Al-Shaar et al.
Sakibul Huq et al.
Background: Population-based studies have linked progestin exposure to increased meningioma risk. However, the molecular basis of meningiomas associated with depot medroxyprogesterone acetate (DMPA) - a common injectable ...
Primary Mismatch Repair Deficient Glioma (PMMRDG), IDH-wildtype and H3-wildtype: A Giant Cell Tumor with Potential for Long-Term Survival Occurring at all Ages [0.03%]
原发性错配修复缺陷型胶质瘤（PMMRDG），IDH野生型和H3野生型：一种多发生于各年龄段并可能长期存活的巨大细胞肿瘤
Abigail K Suwala,Dennis Friedel,Felix E Hinz et al.
Abigail K Suwala et al.
Background: Replication-repair-deficiency is associated with increased risk of developing malignant gliomas. The aim of this study was to investigate primary mismatch repair deficient gliomas (PMMRDGs), a group of IDH-wil...
Final report of the SIOP-CNS-GCT II protocol for germinoma-omitting radiotherapy boost is safe in localized disease in complete remission after chemotherapy [0.03%]
SIOP-CNS-GCT II方案最终报告：化疗后完全缓解的局限性生殖细胞瘤患者无需放射治疗加量
Gabriele Calaminus,Claire Alapetite,Rolf D Kortmann et al.
Gabriele Calaminus et al.
Background: For localized germinoma, whole-ventricular radiotherapy (WVRT) is standard-of-care in Europe; 24 Gray (Gy) with 16Gy boost following chemotherapy. The SIOP-CNS-GCT-II trial aimed to examine the effect of respo...
Spatial dissection of ADC/RPT targets defines heterogeneous expression landscapes and therapeutic implications in rhabdoid tumors [0.03%]
空间分割ADC/RPT靶点定义了肾母细胞瘤的异质性表达景观及其治疗意义
Nic G Reitsam,Victoria E Fincke,Maria Daniela Hernandez Ramirez et al.
Nic G Reitsam et al.
Background: Rhabdoid tumors (RT) are among the most aggressive pediatric malignancies, characterized by early onset in life, loss of SWI/SNF complex members (SMARCB1 or SMARCA4), and dismal outcomes despite multimodal the...
Microenvironment T-Type calcium channels regulate neuronal and glial processes in tumor cells to promote glioblastoma growth [0.03%]
微环境T型钙通道通过调节肿瘤细胞中的神经和胶质过程来促进胶质母细胞瘤生长
Collin J Dube,Ying Zhang,Shekhar Saha et al.
Collin J Dube et al.
Background: Glioblastoma (GBM) is the most common primary malignant brain tumor. The aim of this study was to elucidate the role of microenvironment and intrinsic T-type calcium channels (Cav3) in regulating GBM. ...
Laser Interstitial Thermal Therapy for Brain Metastases: Imaging Guidelines for Clinical Trials and Practice [0.03%]
激光间质热疗治疗脑转移瘤的影像学指南：临床试验与实践指导原则
Francesco Sanvito,Aden P Haskell-Mendoza,Eric C Leuthardt et al.
Francesco Sanvito et al.
Laser interstitial thermal therapy (LITT) is a local surgical treatment for brain metastases (BM). Here, we present and discuss the main radiologic findings and challenges related to LITT-treated BM. Prior to LITT, imaging features are usef...
Spatially-resolved single-cell imaging of melanoma brain metastases identifies localized immune patterns predictive of immune checkpoint blockade response [0.03%]
空间分辨的黑色素瘤脑转移灶单细胞成像识别出局部免疫模式可预测免疫检查点阻断反应
Stefanos Voglis,Daniel Schulz,Nils Eling et al.
Stefanos Voglis et al.
Background: A subset of patients with advanced-stage melanoma with brain metastases respond intracranially to immune-checkpoint inhibitors (ICIs). We reasoned that features of the spatial architecture of the tumor microen...