Evaluation of lapatinib ditosylate nanoparticles for enhanced dissolution rate, oral bioavailability and effective oral carcinoma treatment [0.03%]
评估拉帕替尼二硫酸酯纳米颗粒的增强溶解速率、口服生物利用度和有效口腔癌治疗的效果
Ranga Goud Rayapolu,Harshala Ramesh Patil,Ramalingam Arawindh et al.
Ranga Goud Rayapolu et al.
Lapatinib ditosylate (LD) is a chemotherapeutic agent that belongs to Class II of the Biopharmaceutical Classification System. The objective of this work was to enhance oral bioavailability of LD by developing a nanoparticle solid dispersio...
Praeruptorin A Loaded MIL-100(Fe) Dry Powder Inhalant for Chronic Pulmonary Inflammatory Diseases Therapy [0.03%]
用于慢性肺部炎症疾病治疗的载praeruptorin A的MIL-100（铁）干粉吸入剂
Houyuan Yang,Shuoying Liu,Tingyu Ge et al.
Houyuan Yang et al.
Background: Peucedanum praeruptorum Dunn has long been used in traditional Chinese medicine (TCM) for the treatment of respiratory diseases, its active constituent praeruptorin A (PA) has multiple anti-inflammatory activities.Objective: PA ...
Synergistic Effects of Zn2+/Ca2+ Crosslinking on Alginate-Chitosan Semi-Interpenetrating Networks: Mechanical and pH Responsive Properties [0.03%]
Zn2+/Ca2+交联藻酸盐-壳聚糖半互穿网络的协同效应：力学及pH响应性能
Anil K Philip,Bassim I Mohammad,Betty Annie Samuel et al.
Anil K Philip et al.
Zn2+/Ca2+ synergistic crosslinking was engineered in chitosan-alginate semi-interpenetrating networks (semi-IPNs) to establish crosslinking density (15.2-58.3 mol/m³) as a predictive parameter for multi-scale hydrogel performance. Fourier-...
Fabrication and Optimization of Verapamil-loaded PEGylated Nanoparticles for Management of Traumatic Brain Injury: A Comparative Evaluation [0.03%]
用于创伤性脑损伤管理的维拉帕米载药聚乙二醇纳米颗粒的制备与优化：比较评估
Omnya M Amin,Maha K A Khalifa,Marwa A Abd El-Fattah et al.
Omnya M Amin et al.
Verapamil (VRP) is a calcium channel blocker described for cardiovascular diseases. The reported antioxidant in addition to anti-inflammatory attributes, could present its potential efficacy for traumatic brain injury (TBI). However, brain ...
Chylomicron-Mimicking Supramolecular Nanoemulsion for Oral Luteolin Delivery against Hyperuricemia [0.03%]
一种口服递送芦丁治疗高尿酸的新方法：仿脂蛋白纳米乳剂
Miao Wang,Linlin Zhao,Yujiao Liu et al.
Miao Wang et al.
Hyperuricemia, a prevalent metabolic disorder, severely impacts life quality. Luteolin (LUT), a natural flavonoid compound, demonstrates potential anti-hyperuricemic effects along with a high safety profile. However, its clinical applicatio...
Preparation, characterization and in vivo studies of amorphous solid dispersion of gambogic acid with meglumine [0.03%]
甘松酸与甲硫乙胺无定型固体分散物的制备、表征及体内评价研究
Zhongcheng Ke,Xiaoling Cheng,Yimin Niu et al.
Zhongcheng Ke et al.
The aim of this study was to develop an amorphous solid dispersion system utilizing meglumine (MG) as an alkalizing matrix to improve the dissolution rate and oral bioavailability of gambogic acid (GA). Solid dispersion of GA with MG (GA/MG...
Development of a Stable Microemulsion - Based Delivery of Amlodipine Besylate: A Promising Approach for Topical Treatment of Anal Fissures [0.03%]
开发稳定的微乳基苯磺酸氨氯地平递送系统以 topical 治疗肛裂
C O Pazmiño-Chiluiza,A M Rabasco,M L González-Rodríguez
C O Pazmiño-Chiluiza
Anal fissures (AF) are painful anorectal disorders for which topical calcium - channel blockers (CCBs), such as amlodipine besylate (AMD), are recommended to avoid systemic adverse effects associated with oral therapy. However, the topical ...
Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study [0.03%]
盐酸美西律新型3D打印口服固体制剂的稳定性考察：为期六个月的货架期试验
Anouar Ait Hoummad,Arwin Ramcharan,Fereshteh Shokri
Anouar Ait Hoummad
This study presents the first evaluation of the shelf life of a novel three-dimensional (3D) printed formulation of Mexiletine Hydrochloride (HCl) over a six-month storage period. Mexiletine HCl was incorporated into a patient-personalized ...
Nano-Conjugated Drug Delivery Systems for Enhanced Tumour-Specific Targeting [0.03%]
用于肿瘤特异性靶向的纳米连接药物输送系统
Mirva Hirpara,Priyanka Ahlawat,Asha Patel et al.
Mirva Hirpara et al.
Cancer remains among the major causes of death in the world, yet the treatment has been hampered and hindered by the issue of nonspecific drug toxicity, lack of selectivity and resistance. Drug delivery systems based on nanocarriers have be...
The Functional Attributes of Co-Processed Excipients in Direct Compression [0.03%]
直接压片过程中制备药物辅料的功能属性
Renate Coetzee,Josias Hamman,Jan Steenekamp et al.
Renate Coetzee et al.
The pharmaceutical industry is increasingly adopting co-processed excipients as alternatives to conventional excipients in tablet manufacturing despite certain regulatory challenges. Co-processing of excipients was designed to optimize phys...