Synergistic combination of quercetin and kaempferol via milk exosome-based emulsion for enhanced antioxidant and anti-skin aging efficacy [0.03%]
基于牛奶外泌体乳液的檞皮素和杨梅素的协同组合用于抗氧化和抗皮肤衰老性能增强
Xuemei Gu,Jie Wang,Jing Chen et al.
Xuemei Gu et al.
The natural flavonoids quercetin (Que) and kaempferol (Kae) show great potential for anti-aging applications but suffer from poor solubility and skin permeability. This study aimed to develop a synergistic topical emulsion system to overcom...
Lepidium sativum and Metformin Hydrochloride Hydrogels for Effective Management of Wounds in an Induced Diabetic Rat Model [0.03%]
蔊菜和盐酸二甲双胍凝胶在诱导糖尿病大鼠模型伤口治疗中的有效管理作用研究
Yousef A Bin Jardan,Mustafa R Abdulbaq,Sahar A M Omran et al.
Yousef A Bin Jardan et al.
Diabetic wounds need effective and prompt treatment otherwise, it will be complicated with sever bacterial infections. In this study, hydrogels containing Lepidium sativum seeds aqueous extract (LSae), metformin (MET) and combination (LSae ...
The palatability of commercially available hyoscine butyl bromide syrups for paediatric use in South Africa: Comparative assessment using an electronic tongue [0.03%]
电子舌评估南非市场上用于儿童的氢溴酸东莨菪碱糖浆的适口性：比较评估
Omobolanle A Omoteso,Handsome Ndlovu,Sandile M Khamanga et al.
Omobolanle A Omoteso et al.
Patient rejection of unpalatable products can adversely affect therapeutic adherence, potentially leading to treatment failure. Taste masking is a goal in pharmaceutical development, particularly when developing formulations for paediatric ...
Polyphenols-composed micelles: production, physicochemical characterization, in silico pharmacokinetics, and rheological behaviour of a new colloidal system for dual delivery of resveratrol and rutin [0.03%]
由多酚组成的米勒：生成，物理化学特征，计算机辅助药代动力学性质及茋和芸固醇新型胶体体系的流变行为
Beatriz N Guedes,João G De Oliveira Neto,Aleksandra Zielińska et al.
Beatriz N Guedes et al.
A new delivery system for the dual loading of resveratrol and rutin (RES-RU-micelles), is described and characterized. Analyzes were carried out to determine the size parameters (mean particle size and polydispersity index) and surface elec...
Pulmonary Targeted Inhalational Therapy for Neutrophillic Asthma Using a Novel Simvastatin-Rapamycin Dry Powder Inhalation Formulation [0.03%]
一种新型辛伐他汀-雷帕霉素干粉吸入剂针对中性粒细胞型哮喘的肺部给药研究
Hafsa P V,Nithya Haridas,Vidya Viswanad
Hafsa P V
Neutrophillic asthma, characterized by persistent airway inflammation and poor corticosteroid responsiveness, presents a significant therapeutic challenge. Repurposing rapamycin, an mTOR inhibitor, and simvastatin, a statin with anti-inflam...
Zoomlab™-Guided Co-crystal Engineering of Nilotinib for Improved Dissolution [0.03%]
用于提高尼洛替尼溶解度的共晶工程学指导研究
Rahul Jha,Arzoo Sekhani,Nikita Panchal et al.
Rahul Jha et al.
Nilotinib (NH), a second-generation tyrosine kinase inhibitor for chronic myelogenous leukemia (CML), exhibits poor aqueous solubility and low intestinal permeability, classifying it as a Biopharmaceutics Classification System (BCS) Class I...
Enhancing Solubility and Therapeutic Potential of Rosuvastatin via β-Cyclodextrin Inclusion Complex-Loaded Chitosan Nanoparticles [0.03%]
通过β-环糊精包合复合物载药壳聚糖纳米粒增强 rosuvastatin 的溶解度及治疗潜力
Akash V Narawade,Manoj B Shinde,Varsha B Mane et al.
Akash V Narawade et al.
Rosuvastatin is a BCS class II drug effective in the management of atherosclerosis. To enhance solubility and efficacy, Rosuvastatin-β-Cyclodextrin complex-loaded chitosan nanoparticles (R-CD-CNs) were developed. β-cyclodextrin was crossl...
Balisa Mosisa Ejeta,Malay K Das,Sanjoy Das et al.
Balisa Mosisa Ejeta et al.
Harnessing the immune system, vaccines function as both prophylactic shields and precision-guided therapeutic agents, offering a promising strategy of a dual-armament approach in the fight against cancer. Previous landmark advances include ...
Abhay Thakur,Rohit Sharma,Rahul Sharma et al.
Abhay Thakur et al.
Nanozymes are engineered nanoparticles that mimic enzyme-like catalytic activities and have gained significant attention in bioanalytical and biomedical applications. A broad range of nanomaterials has been explored for their intrinsic cata...
Nanostructured Lipid Nanoparticles Delivering Berberine with Se Coating: A New Nanotherapeutic Approach against Cryptosporidiosis [0.03%]
壳状硒涂层载小檗碱的纳米结构脂质纳米粒治疗隐孢子虫病的新策略研究
Areej Eskandrani,Sara H Akl,Yahya H Shahin et al.
Areej Eskandrani et al.
Berberine (BBR) exhibits broad antimicrobial and metabolic activities but suffers from limited bioavailability. Nanostructured lipid carriers (NLCs) can enhance oral delivery, while selenium (Se) coating may synergistically improve hypoglyc...