Unraveling Mendel's final mysteries: A genomic retelling of pea genetics [0.03%]
解开孟德尔最后的谜题：豌豆基因组学的故事
Murukarthick Jayakodi,Preethi Purushotham,Nils Stein
Murukarthick Jayakodi
Using modern genomic tools, Feng et al. revisited Mendel's seven pea traits in a recent Nature study, uncovering the molecular genetic basis of all of them, including the three unresolved ones: pod color, pod shape, and flower position. The...
Meghan B Ward,Giedre Krenciute
Meghan B Ward
Understanding acute and long-term adverse events following CAR T cell therapy for cancer remains a crucial area of investigation as CAR T cells become more prominent in the clinic. In this issue of Cell, Geraghty and Acosta-Alvarez et al. i...
Dopamine encodes deep network teaching signals for individual learning trajectories [0.03%]
多巴胺编码深度网络教学信号以进行个体学习路径研究
Samuel Liebana,Aeron Laffere,Chiara Toschi et al.
Samuel Liebana et al.
Striatal dopamine plays fundamental roles in fine-tuning learned decisions. However, when learning from naive to expert, individuals often exhibit diverse learning trajectories, defying understanding of its underlying dopaminergic mechanism...
Phenotypic landscape of an invasive fungal pathogen reveals its unique biology [0.03%]
表型景观揭示了入侵性真菌病原体的独特生物学特性
Michael J Boucher,Sanjita Banerjee,Meenakshi B Joshi et al.
Michael J Boucher et al.
Cryptococcus neoformans is the most common cause of fungal meningitis and the top-ranking WHO fungal priority pathogen. Only distantly related to model fungi, C. neoformans is also a powerful experimental system for exploring conserved euka...
Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes [0.03%]
神经肽赋予并重新编程切叶蚁Atta cephalotes的职能分工
Michael B Gilbert,Karl M Glastad,Maxxum Fioriti et al.
Michael B Gilbert et al.
Social insects offer powerful models to investigate mechanisms of elaborate individual behaviors comprising a cooperative community. Workers of the leafcutter ant genus Atta are extreme examples of behavioral segregation among phenotypicall...
MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma [0.03%]
MT-125通过抑制非肌肉型肌球蛋白IIA和IIB来延长胶质母细胞瘤患者的生存期
Rajappa S Kenchappa,Laszlo Radnai,Erica J Young et al.
Rajappa S Kenchappa et al.
Glioblastoma (GBM) is the most lethal of primary brain tumors. Here, we report our studies of MT-125, a small-molecule inhibitor of non-muscle myosin II. MT-125 has high brain penetrance and an excellent safety profile, blocks GBM invasion ...
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy [0.03%]
通过诱导线粒体自噬来解开线粒体对哺乳动物多能性的影响
Daniel A Schmitz,Seiya Oura,Leijie Li et al.
Daniel A Schmitz et al.
Mitochondrial abundance and genome are crucial for cellular function, with disruptions often associated with disease. However, methods to modulate these parameters for direct functional dissection remain limited. Here, we eliminate mitochon...
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids [0.03%]
微生物组可使长链和短链脂肪酸来源的N-酰基甘油衍生脂质发生多样化
Helena Mannochio-Russo,Vincent Charron-Lamoureux,Martijn van Faassen et al.
Helena Mannochio-Russo et al.
N-Acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N-acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference spec...
Unveiling the origins and genetic makeup of the "forgotten people": A study of the Sarmatian-period population in the Carpathian Basin [0.03%]
揭开“被遗忘的人”的起源和遗传构成：喀尔巴阡盆地萨马提亚时期人群研究
Oszkár Schütz,Zoltán Maróti,Balázs Tihanyi et al.
Oszkár Schütz et al.
The nomadic Sarmatians dominated the Pontic Steppe from the 3rd century BCE and the Great Hungarian Plain from 50 CE until the Huns' 4th-century expansion. In this study, we present a large-scale genetic analysis of 156 genomes from 1st- to...
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling [0.03%]
神经内分泌细胞通过沙漠型 Hedgehog 信号协调再生过程
William Kong,Wan-Jin Lu,Megha Dubey et al.
William Kong et al.
Understanding the mechanisms underlying mammalian regeneration may enable development of novel regenerative therapies. We present a mechanism wherein Desert hedgehog (Dhh), secreted from epithelial neuroendocrine cells, elicits a regenerati...