Systematic profiling reveals betaine as an exercise mimetic for geroprotection [0.03%]
系统性分析发现甜菜碱可作为防衰运动模拟剂
Lingling Geng,Jiale Ping,Ruochen Wu et al.
Lingling Geng et al.
Exercise has well-established health benefits, yet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics analysis to compare the effects of acute vs. long-term exercise in healthy males. Acute ex...
A host organelle integrates stolen chloroplasts for animal photosynthesis [0.03%]
一个宿主细胞器整合了被盗的叶绿体进行动物光合作用
Corey A H Allard,Angus B Thies,Rishav Mitra et al.
Corey A H Allard et al.
Eukaryotic life evolved over a billion years ago when ancient cells engulfed and integrated prokaryotes to become modern mitochondria and chloroplasts. Sacoglossan "solar-powered" sea slugs possess the ability to acquire organelles within a...
The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved [0.03%]
SARS-CoV-2 NiRAN结构域介导的GTP依赖的RNA加帽机制尚未解析
Gabriel I Small,Seth A Darst,Elizabeth A Campbell
Gabriel I Small
The Nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain initiates mRNA capping in coronaviruses through a GDP-polyribonucleotidyltransferase reaction, with RNA covalently linked to nsp9. GDP is the preferred substrate for this r...
An iPSC-derived CD19/BCMA CAR-NK therapy in a patient with systemic sclerosis [0.03%]
一名系统性硬化症患者的iPSC衍生CD19 / BCMA CAR-NK疗法
Xiaobing Wang,Yi Zhang,Yi Jin et al.
Xiaobing Wang et al.
This study reports the first-in-human application of iPSC-derived CD19/BCMA dual-targeting chimeric antigen receptor-natural killer (CAR-NK) cells (QN-139b) in a patient with severe, diffuse cutaneous systemic sclerosis. The allogeneic prod...
Xinlu Ding,Fuu-Jiun Hwang,Daniel Silverman et al.
Xinlu Ding et al.
Sleep is known to promote tissue growth and regulate metabolism, partly by enhancing growth hormone (GH) release, but the underlying circuit mechanism is unknown. We demonstrate how GH release, which is enhanced during both rapid eye moveme...
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity [0.03%]
用于治疗二型糖尿病和肥胖的偏向于GRK的肾上腺素受体激动剂
Aikaterini Motso,Benjamin Pelcman,Anastasia Kalinovich et al.
Aikaterini Motso et al.
Biased agonism of G protein-coupled receptors (GPCRs) offers potential for safer medications. Current efforts have explored the balance between G proteins and β-arrestin; however, other transducers like GPCR kinases (GRKs) remain understud...
Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment [0.03%]
解析人类加速区域在人和黑猩猩神经发育过程中的三维互作组
Atreyo Pal,Mark A Noble,Matheo Morales et al.
Atreyo Pal et al.
Published Erratum
Cell. 2025 Jun 21:S0092-8674(25)00688-9. DOI:10.1016/j.cell.2025.06.022 2025
Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment [0.03%]
可扩展生成和遗传变异的功能分类以加速先天性免疫缺陷的临床诊断和治疗
Zachary H Walsh,Chris J Frangieh,Neeharika Kothapalli et al.
Zachary H Walsh et al.
Next-generation sequencing is pivotal for diagnosing inborn errors of immunity (IEI) but predominantly yields variants of uncertain significance (VUS), creating clinical ambiguity. Activated PI3Kδ syndrome (APDS) is caused by gain-of-funct...
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling [0.03%]
胆碱能神经元活性通过毒蕈碱信号促进弥漫性中线胶质瘤生长
Richard Drexler,Antonia Drinnenberg,Avishai Gavish et al.
Richard Drexler et al.
Glutamatergic neuronal activity promotes proliferation of both oligodendrocyte precursor cells (OPCs) and gliomas, including diffuse midline glioma (DMG). However, the role of neuromodulatory brainstem neurons projecting to midline structur...
Bivalent chromatin instructs lineage specification during hematopoiesis [0.03%]
双价染色体在造血过程中的谱系分化中起指导作用
Masaki Yagi,Gracia Bonilla,Michael S Hoetker et al.
Masaki Yagi et al.
Developmental gene expression is regulated by the dynamic interplay of histone H3 lysine 4 (H3K4) and histone H3 lysine 27 (H3K27) methylation, yet the physiological roles of these epigenetic modifications remain incompletely understood. He...